SIMONI, Daniele
 Distribuzione geografica
Continente #
NA - Nord America 10.423
EU - Europa 2.631
AS - Asia 1.912
SA - Sud America 13
Continente sconosciuto - Info sul continente non disponibili 11
AF - Africa 9
OC - Oceania 7
Totale 15.006
Nazione #
US - Stati Uniti d'America 10.407
CN - Cina 1.054
UA - Ucraina 692
TR - Turchia 575
DE - Germania 568
IT - Italia 364
GB - Regno Unito 336
SE - Svezia 293
SG - Singapore 165
FI - Finlandia 155
VN - Vietnam 56
FR - Francia 45
RU - Federazione Russa 43
PL - Polonia 40
NL - Olanda 28
BE - Belgio 25
CA - Canada 15
CZ - Repubblica Ceca 14
IN - India 12
KR - Corea 10
EU - Europa 9
IR - Iran 9
AU - Australia 7
CL - Cile 7
JP - Giappone 6
BR - Brasile 5
ES - Italia 5
IE - Irlanda 5
IQ - Iraq 5
MA - Marocco 5
RO - Romania 5
TW - Taiwan 5
HK - Hong Kong 4
ID - Indonesia 4
CH - Svizzera 3
HU - Ungheria 3
A2 - ???statistics.table.value.countryCode.A2??? 2
DZ - Algeria 2
NO - Norvegia 2
AF - Afghanistan, Repubblica islamica di 1
AT - Austria 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
BW - Botswana 1
DK - Danimarca 1
GE - Georgia 1
GR - Grecia 1
JO - Giordania 1
MX - Messico 1
MY - Malesia 1
PE - Perù 1
PK - Pakistan 1
RS - Serbia 1
TH - Thailandia 1
TN - Tunisia 1
Totale 15.006
Città #
Fairfield 1.479
Woodbridge 1.298
Houston 902
Ashburn 804
Jacksonville 785
Chandler 722
Seattle 655
Ann Arbor 634
Wilmington 529
Cambridge 466
Izmir 250
Nanjing 245
Beijing 189
Princeton 159
Boardman 147
San Diego 139
New York 137
Addison 104
Singapore 95
Shanghai 80
Shenyang 79
Nanchang 71
Hebei 59
Milan 58
San Mateo 55
Dong Ket 54
Ferrara 54
Changsha 52
Tianjin 49
Bremen 42
Jinan 41
Warsaw 38
Jiaxing 34
Falls Church 32
London 26
Brussels 25
Philadelphia 25
Verona 24
Munich 23
Auburn Hills 21
Norwalk 21
Amsterdam 20
Los Angeles 20
Mountain View 19
Chicago 17
Guangzhou 17
Zhengzhou 17
Dearborn 16
Kunming 16
Redwood City 16
Mcallen 15
Taizhou 15
Washington 15
Bologna 14
Hangzhou 13
Montréal 12
Indiana 11
Helsinki 10
Tappahannock 10
Augusta 9
Changchun 9
Des Moines 9
Monmouth Junction 9
Düsseldorf 8
Haikou 8
Ningbo 8
Orange 8
Palermo 8
Redmond 8
Lanzhou 7
Olomouc 7
Brno 6
Fuzhou 6
Kilburn 6
Leawood 6
Ardabil 5
Dallas 5
Dublin 5
San Francisco 5
Taipei 5
Xian 5
Yellow Springs 5
Ferrara di Monte Baldo 4
Moscow 4
Rome 4
San Calogero 4
San Jose 4
Jakarta 3
Madrid 3
Mangalore 3
New Haven 3
Padova 3
Paris 3
Pietro 3
Taiyuan 3
Wenzhou 3
A Coruña 2
Absecon 2
Acton 2
Albignasego 2
Totale 11.187
Nome #
1,2,4-triazoles. Improved synthesis of 5-substituited 4-amino-3mercato-(4H)-1,2,4 triazoles and a facile route to 3,6-disubstituited 1,24-triazolo[3,4b][1,3,4]thiadiazoles 242
1,5,7-Triazabicyclo[4.4.0]dec-1- ene (TBD), 7-Methyl-TBD (MTBD) and the polymer-supported TBD (P-TBD):Three efficient catalysts for the nitroaldol (Henry) reaction and for the addition of dialkyl phosphites to unsaturated systems. 221
Retinoic acid conjugates as potential antitumor agents: Synthesis and biological activity of conjugates with Ara-A, Ara-C, 3(2H)-furanone, and aniline mustard moieties 180
Hydropathic analysis and biological evaluation of stilbene derivatives as colchicine site microtubule inhibitors with anti-leukemic activity. 160
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors 160
Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives. 158
New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting 152
A facile, efficient synthesis of 2-substituted-4-hydroxy-2-cyclopenten-1-ones 149
Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor. 149
Effects of Pimozide Derivatives on pSTAT5 in K562 Cells 145
Geiparvarin analogs. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates. 142
Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death. 142
3,5-Disubstituted isoxazoles as a latent aldol moiety: application to the synthesis of (±)-[6]-gingerol. 141
Methyl 4-oxothiolane-3-carboxylate and methyl 2-methyl-4-oxothiolane-3- carboxylate anions as synthetic equivalents of α-acrylate and α-crotonate anions. Formal synthesis of integerrinecic acid 140
Synthesis of 8-oxa analogues of norcocaine endowed with interesting cocaine-like activity 140
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation 140
Ethyl 2,4-dioxoalkanoates as starting materials for a convenient route to 3(2H)-furanones and 3(2H)-furanimines 139
Geiparvarin Analogs. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain 139
Lack of nucleophilic addition in the isoxazole and pyrazole diketone modified analogs of curcumin; implications for their antitumor and chemosensitizing activities. 139
A [3+2] nitrile oxide intermolecular cycloaddition approach to 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone ring systems: application to the formal synthesis of (±)-ascofuranone and geiparvarin. 139
3,5-Disubstituted isoxazoles as synthons for (±)-pyrenophorin and (±)-vermiculine synthesis. 136
Geiparvarin Analogs. 4.1. Synthesis and Cytostatic Activity of Geiparvarin Analogs Bearing a Carbamate Moiety or a Furocoumarin Fragment on the Alkenyl Side Chain 135
Arylamidonaphtalene sulfonate compounds as a novel class of heparanase inhibitors 135
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents 133
A [3 + 2] nitrile oxide cycloaddition approach to retinoids 131
A convenient synthesis of unsymmetrically substituted terphenyls of biologically active stilbenes via a double Suzuki cross-coupling protocol 129
Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth 127
Synthesis of 2-(5-substituted isoxazol-3-yl)-4-oxo-3-thiazolidinyl alkanoic acids 126
null 125
null 125
A new nitrile oxide based synthesis of the antitumor agent geiparvarin 124
Total synthesis of (±)-isoclovene. 124
Development of water soluble derivatives of cis-3, 4', 5-trimethoxy-3'-aminostilbene for optimization and use in cancer therapy. 124
A new direct glycosylation of pyrimidine, pyrazole, imidazole and purine heterocycles via their N-tetrahydropyranyl (THP) derivatives 124
Synthesis of syn- and anti-tricyclo[4.1.0.02,4]heptan-5-ones and related compounds. 121
Synthesis of 6‐substituted‐4,5‐dihydro‐3(2H)‐pyridazinones 120
Synthesis of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine and 1,2,3-triazolo[4,5-e]1,2,4-triazolo[1,5-c]pyrimidine displaying potent and selective activity as A2a adenosine receptor antagonists 120
A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approach 120
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl- and 8-ethynyladenosine 119
Pyrazole-Related Nucleosides. Synthesis and Antiviral/Antitumor Activity of Some Substituted Pyrazole and Pyrazolo[4,3-d]-1,2,3-triazin-4-one Nucleosides 118
Synthesis and pharmacology of 6-substituted benztropines: Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter 118
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity 118
ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis 117
Preparation of 3,4-dihydroxy-1-benzeneethanol: a reinvestigation 116
Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines 116
Sintesi di derivati pirazolici e pirazolo[4,3-d]pirimidonici. Nota I 116
Stereospecific nitromethane conjugate addition to 4-oxygenated 2-substituted cyclopent-2-enones: a simple approach to prostaglandins. 115
Cyclic guanidines: Synthesis of 4,6,7,8‐tetrahydro‐1H‐imidazo[1,2‐a]pyrazolo[3,4‐d]pyrimidin‐7‐ones and 1,4,6,7,8,9‐hexahydropyrazolo[3′,4′:4,5]pyrimido[2,1‐c] [1,2,4]triazin‐7‐ones 115
Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties 115
Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter 113
A one-pot glycosylation of tetrahydropyranyl (THP) ether intermediates 112
Studies on the apoptotic activity of natural and synthetic retinoids: Discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells 112
Synthesis of natural products via isoxazoles. 109
cis-3, 4', 5-Trimethoxy-3'-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion. 109
Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer 109
Mechanism of cell death induced by cis-3, 4', 5-trimethoxy-3'-aminostilbene in ovarian cancer. 108
Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogs of pyrrolo[1,4]benzodiazepines (PBDs) 107
Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells. 105
Concise enantioselective synthesis and attribution of the absolute configuration of two-carbon bridge methoxylated cocaines and pseudococaines 105
Facile access to 2'-O-acyl prodrugs of 1-(β-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2',3',5'-triesters 104
Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells 104
Sintesi di derivati pirazolici e pirazolo[4,3-d]pirimidonici. Nota II 104
Stereoselective synthesis of 8-aza-9,11-ethenoprostaglandin H1 103
Synthesis and reactivity of a stable precursor of 2-cyano-1,3-butadiene 102
Facile synthesis of pyrazoles and pyrroles via thermolysis of tetrazolo[1,5-b]pyridazines, tetrazolo[1,5-a]pyrimidines and tetrazolo[1,5-a]pyridines 102
Two-carbon bridge substituted cocaines: enantioselective synthesis, attribution of the absolute configuration and biological activity of novel 6- and 7-methoxylated cocaines. 101
Strong Bicyclic Guanidine Base-promoted Wittig and Horner-Wadsworth-Emmons Reactions 101
Novel combretastatin analogues endowed with antitumor activity 101
Design, synthesis and biological evaluation of novel stilbene-based antitumor agents 100
Synthesis of 5-Hydroxy-2-oxotetrahydropyrroles 100
Synthesis of 1-phenyl-substituted 3-methyl-1H-pyrazolo[3,4-b]pyrazine-5,6-dicarboxylic acid diethyl esters. 100
Synthesis of an 11-Deoxy-8-azaprostaglandin E1 Intermediate 99
Structure-activity relationship studies of novel heteroretinoids: Induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid 99
Antitumor effects of new synthetic isoxazole derivatives 99
Facile synthesis of 2-nitroalkanols by Tetramethylguanidine (TMG)-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones 98
The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: Analysis of the possible molecular basis 97
Synthesis of new 2,2 '-disubstituted 5,5 '-dimethyl-4,4 '-bitriazoles and 2-(4-triazolyl)quinoxalines 97
Synthesis and Antitumor Activity of a New Class of Pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone Analogs of Pyrrolo[1,4][2,1-c]benzodiazepines 97
Anticancer drugs targeting the apoptotic pathway 96
Enantioselective deprotonation of the 8-oxabicyclo[3.2.1]octan-3-one: Synthesis of 8-oxa-norcocaines and 8-oxa-pseudonorcocaines 96
The synergistic apoptotic effects of thiophenfurin, an inosine monophosphate dehydrogenase inhibitor, in combination with retinoids in HL60 cells 96
Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells. 95
Stilbene derivatives that are colchicine site microtubule inhibitors have antileukemic activity and minimal systemic toxicity 95
Design, synthesis and antiproliferative activity of methyl 4-iodo-1-b-D-ribofuranosyl-pyrazole-3-carboxylate and related compounds 93
Synthesis of 3-Methyl-6-phenylamino-substituted-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones 93
Synthesis and Cytostatic Activity of Geiparvarin Analogues 92
Antitumor effects of curcumin and structurally β-diketone modified analogs on multidrug resistant cancer cells 92
Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells 92
Effects of chemically modified tetracyclines (CMTs) in sensitive, multidrug resistant and apoptosis resistant leukaemia cell lines 91
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells 91
Regio - and enantioselective bioreduction of ethyl 2,4-dioxoalkanoates and γ-Keto-α-enamino esters with fermenting baker's yeast 91
Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici 90
Asymmetric synthesis of a β-ketol moiety via 3,5-disubstituted isoxazoles: Application to (+)-(S)-[6]-gingerol 89
A PLE-based resolution of cocaine, pseudococaine and 6-and 7-methoxylated cocaine analogues 87
Tyrosine kinase ihibitors for the treatment of chronic myeloid leukemia 85
Retinoids, apoptosis and cancer 84
null 83
Synthesis and evaluation of the antifungal activity of a new class of N-acylureas 83
3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis and evaluation for antimicrobial and antiviral activity. III. 83
Pig liver esterase (PLE)-mediated resolution of N-substituted 4-benzoyloxy-3-carbomethoxypiperidines: a convenient preparation of 4-hydroxy- and 4-benzoyloxy-3-carbomethoxypiperidines in enantiomerically pure form 83
Totale 11.656
Categoria #
all - tutte 57.393
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 295
Totale 57.688


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20203.453 573 123 132 508 234 392 296 340 279 388 126 62
2020/20212.213 181 225 130 228 65 235 65 249 49 283 300 203
2021/20221.818 67 127 129 107 186 88 71 83 86 94 162 618
2022/20231.678 169 109 57 207 307 261 40 159 215 12 82 60
2023/2024891 92 100 64 22 57 196 42 63 15 27 28 185
2024/202593 93 0 0 0 0 0 0 0 0 0 0 0
Totale 15.187