SIMONI, Daniele
 Distribuzione geografica
Continente #
NA - Nord America 11.115
EU - Europa 2.778
AS - Asia 2.254
SA - Sud America 15
Continente sconosciuto - Info sul continente non disponibili 11
AF - Africa 9
OC - Oceania 8
Totale 16.190
Nazione #
US - Stati Uniti d'America 11.080
CN - Cina 1.097
UA - Ucraina 692
DE - Germania 599
TR - Turchia 576
SG - Singapore 447
IT - Italia 405
GB - Regno Unito 354
SE - Svezia 293
FI - Finlandia 179
VN - Vietnam 56
FR - Francia 47
RU - Federazione Russa 43
PL - Polonia 40
BE - Belgio 39
CA - Canada 34
NL - Olanda 33
CZ - Repubblica Ceca 15
ID - Indonesia 13
IN - India 12
KR - Corea 11
JP - Giappone 10
EU - Europa 9
IR - Iran 9
AU - Australia 8
LT - Lituania 8
CL - Cile 7
BR - Brasile 6
IE - Irlanda 6
ES - Italia 5
IQ - Iraq 5
MA - Marocco 5
RO - Romania 5
TW - Taiwan 5
HK - Hong Kong 4
NO - Norvegia 4
CH - Svizzera 3
HU - Ungheria 3
A2 - ???statistics.table.value.countryCode.A2??? 2
DZ - Algeria 2
MY - Malesia 2
AF - Afghanistan, Repubblica islamica di 1
AR - Argentina 1
AT - Austria 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
BW - Botswana 1
DK - Danimarca 1
GE - Georgia 1
GR - Grecia 1
JO - Giordania 1
MX - Messico 1
PE - Perù 1
PH - Filippine 1
PK - Pakistan 1
RS - Serbia 1
TH - Thailandia 1
TN - Tunisia 1
Totale 16.190
Città #
Fairfield 1.479
Woodbridge 1.298
Houston 902
Ashburn 806
Jacksonville 785
Chandler 722
Seattle 655
Ann Arbor 634
Wilmington 529
Santa Clara 494
Cambridge 466
Singapore 360
Izmir 250
Nanjing 245
Beijing 189
Princeton 159
Boardman 147
New York 139
San Diego 139
Addison 104
Shanghai 80
Shenyang 79
Nanchang 71
Hebei 59
Milan 58
Los Angeles 57
San Mateo 55
Dong Ket 54
Ferrara 54
Changsha 53
Tianjin 49
Bremen 42
Jinan 41
Brussels 39
London 38
Warsaw 38
Jiaxing 34
Helsinki 33
Falls Church 32
Munich 30
Philadelphia 25
Verona 24
Auburn Hills 21
Norwalk 21
Amsterdam 20
Guangzhou 20
Mountain View 19
Frankfurt am Main 18
Chicago 17
Zhengzhou 17
Bologna 16
Dearborn 16
Kunming 16
Redwood City 16
Washington 16
Mcallen 15
Taizhou 15
Hangzhou 13
Toronto 13
Jakarta 12
Montréal 12
Indiana 11
Tappahannock 10
Augusta 9
Changchun 9
Des Moines 9
Monmouth Junction 9
Düsseldorf 8
Haikou 8
Ningbo 8
Orange 8
Ottawa 8
Palermo 8
Redmond 8
Lanzhou 7
Olomouc 7
Brno 6
Dublin 6
Fuzhou 6
Kilburn 6
Leawood 6
Rome 6
Ardabil 5
Dallas 5
San Francisco 5
Taipei 5
Xian 5
Yellow Springs 5
Falkenstein 4
Ferrara di Monte Baldo 4
Moscow 4
San Calogero 4
San Jose 4
Madrid 3
Mangalore 3
New Haven 3
Padova 3
Paris 3
Pietro 3
Taiyuan 3
Totale 12.094
Nome #
1,2,4-triazoles. Improved synthesis of 5-substituited 4-amino-3mercato-(4H)-1,2,4 triazoles and a facile route to 3,6-disubstituited 1,24-triazolo[3,4b][1,3,4]thiadiazoles 271
1,5,7-Triazabicyclo[4.4.0]dec-1- ene (TBD), 7-Methyl-TBD (MTBD) and the polymer-supported TBD (P-TBD):Three efficient catalysts for the nitroaldol (Henry) reaction and for the addition of dialkyl phosphites to unsaturated systems. 231
Retinoic acid conjugates as potential antitumor agents: Synthesis and biological activity of conjugates with Ara-A, Ara-C, 3(2H)-furanone, and aniline mustard moieties 187
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors 173
Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives. 169
A facile, efficient synthesis of 2-substituted-4-hydroxy-2-cyclopenten-1-ones 168
Hydropathic analysis and biological evaluation of stilbene derivatives as colchicine site microtubule inhibitors with anti-leukemic activity. 167
New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting 163
Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor. 159
3,5-Disubstituted isoxazoles as a latent aldol moiety: application to the synthesis of (±)-[6]-gingerol. 157
A [3+2] nitrile oxide intermolecular cycloaddition approach to 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone ring systems: application to the formal synthesis of (±)-ascofuranone and geiparvarin. 154
Effects of Pimozide Derivatives on pSTAT5 in K562 Cells 154
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation 152
3,5-Disubstituted isoxazoles as synthons for (±)-pyrenophorin and (±)-vermiculine synthesis. 149
Geiparvarin analogs. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates. 148
Methyl 4-oxothiolane-3-carboxylate and methyl 2-methyl-4-oxothiolane-3- carboxylate anions as synthetic equivalents of α-acrylate and α-crotonate anions. Formal synthesis of integerrinecic acid 147
Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death. 146
Geiparvarin Analogs. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain 145
Ethyl 2,4-dioxoalkanoates as starting materials for a convenient route to 3(2H)-furanones and 3(2H)-furanimines 144
Lack of nucleophilic addition in the isoxazole and pyrazole diketone modified analogs of curcumin; implications for their antitumor and chemosensitizing activities. 144
Synthesis of 8-oxa analogues of norcocaine endowed with interesting cocaine-like activity 143
Arylamidonaphtalene sulfonate compounds as a novel class of heparanase inhibitors 143
A convenient synthesis of unsymmetrically substituted terphenyls of biologically active stilbenes via a double Suzuki cross-coupling protocol 143
A [3 + 2] nitrile oxide cycloaddition approach to retinoids 140
Geiparvarin Analogs. 4.1. Synthesis and Cytostatic Activity of Geiparvarin Analogs Bearing a Carbamate Moiety or a Furocoumarin Fragment on the Alkenyl Side Chain 140
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents 138
Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth 137
Development of water soluble derivatives of cis-3, 4', 5-trimethoxy-3'-aminostilbene for optimization and use in cancer therapy. 135
Synthesis of 2-(5-substituted isoxazol-3-yl)-4-oxo-3-thiazolidinyl alkanoic acids 133
A new nitrile oxide based synthesis of the antitumor agent geiparvarin 133
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity 133
A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approach 131
Synthesis and pharmacology of 6-substituted benztropines: Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter 131
A new direct glycosylation of pyrimidine, pyrazole, imidazole and purine heterocycles via their N-tetrahydropyranyl (THP) derivatives 131
Total synthesis of (±)-isoclovene. 129
Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines 129
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl- and 8-ethynyladenosine 128
Synthesis of syn- and anti-tricyclo[4.1.0.02,4]heptan-5-ones and related compounds. 128
Synthesis of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine and 1,2,3-triazolo[4,5-e]1,2,4-triazolo[1,5-c]pyrimidine displaying potent and selective activity as A2a adenosine receptor antagonists 128
Synthesis of 6‐substituted‐4,5‐dihydro‐3(2H)‐pyridazinones 126
Cyclic guanidines: Synthesis of 4,6,7,8‐tetrahydro‐1H‐imidazo[1,2‐a]pyrazolo[3,4‐d]pyrimidin‐7‐ones and 1,4,6,7,8,9‐hexahydropyrazolo[3′,4′:4,5]pyrimido[2,1‐c] [1,2,4]triazin‐7‐ones 126
Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties 126
Preparation of 3,4-dihydroxy-1-benzeneethanol: a reinvestigation 125
Stereospecific nitromethane conjugate addition to 4-oxygenated 2-substituted cyclopent-2-enones: a simple approach to prostaglandins. 125
null 125
null 125
Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter 124
Pyrazole-Related Nucleosides. Synthesis and Antiviral/Antitumor Activity of Some Substituted Pyrazole and Pyrazolo[4,3-d]-1,2,3-triazin-4-one Nucleosides 123
A one-pot glycosylation of tetrahydropyranyl (THP) ether intermediates 121
ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis 121
Sintesi di derivati pirazolici e pirazolo[4,3-d]pirimidonici. Nota I 121
Studies on the apoptotic activity of natural and synthetic retinoids: Discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells 121
Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells. 117
Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer 116
Design, synthesis and biological evaluation of novel stilbene-based antitumor agents 116
Cis-3, 4′, 5-Trimethoxy-3′-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion 114
Concise enantioselective synthesis and attribution of the absolute configuration of two-carbon bridge methoxylated cocaines and pseudococaines 114
Synthesis of natural products via isoxazoles. 113
Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici 113
Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogs of pyrrolo[1,4]benzodiazepines (PBDs) 113
Mechanism of cell death induced by cis-3, 4′, 5-trimethoxy-3′-aminostilbene in ovarian cancer 112
Strong Bicyclic Guanidine Base-promoted Wittig and Horner-Wadsworth-Emmons Reactions 112
Sintesi di derivati pirazolici e pirazolo[4,3-d]pirimidonici. Nota II 112
Novel combretastatin analogues endowed with antitumor activity 111
Stereoselective synthesis of 8-aza-9,11-ethenoprostaglandin H1 111
Facile access to 2'-O-acyl prodrugs of 1-(β-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2',3',5'-triesters 110
Facile synthesis of 2-nitroalkanols by Tetramethylguanidine (TMG)-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones 110
Synthesis and reactivity of a stable precursor of 2-cyano-1,3-butadiene 109
Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells 109
Synthesis of 1-phenyl-substituted 3-methyl-1H-pyrazolo[3,4-b]pyrazine-5,6-dicarboxylic acid diethyl esters. 109
Antitumor effects of new synthetic isoxazole derivatives 109
The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: Analysis of the possible molecular basis 108
Facile synthesis of pyrazoles and pyrroles via thermolysis of tetrazolo[1,5-b]pyridazines, tetrazolo[1,5-a]pyrimidines and tetrazolo[1,5-a]pyridines 106
Synthesis of an 11-Deoxy-8-azaprostaglandin E1 Intermediate 105
Two-carbon bridge substituted cocaines: enantioselective synthesis, attribution of the absolute configuration and biological activity of novel 6- and 7-methoxylated cocaines. 105
Antitumor effects of curcumin and structurally β-diketone modified analogs on multidrug resistant cancer cells 105
Structure-activity relationship studies of novel heteroretinoids: Induction of apoptosis in the HL-60 cell line by a novel isoxazole-containing heteroretinoid 104
Synthesis of 5-Hydroxy-2-oxotetrahydropyrroles 104
Enantioselective deprotonation of the 8-oxabicyclo[3.2.1]octan-3-one: Synthesis of 8-oxa-norcocaines and 8-oxa-pseudonorcocaines 103
Synthesis and Antitumor Activity of a New Class of Pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone Analogs of Pyrrolo[1,4][2,1-c]benzodiazepines 103
Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells. 102
Synthesis of new 2,2 '-disubstituted 5,5 '-dimethyl-4,4 '-bitriazoles and 2-(4-triazolyl)quinoxalines 101
The synergistic apoptotic effects of thiophenfurin, an inosine monophosphate dehydrogenase inhibitor, in combination with retinoids in HL60 cells 101
Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells 100
Anticancer drugs targeting the apoptotic pathway 99
Design, synthesis and antiproliferative activity of methyl 4-iodo-1-b-D-ribofuranosyl-pyrazole-3-carboxylate and related compounds 98
Stilbene derivatives that are colchicine site microtubule inhibitors have antileukemic activity and minimal systemic toxicity 98
Synthesis of 3-Methyl-6-phenylamino-substituted-1H-pyrazolo[4,3-d]pyrimidine-7(6H)-ones 97
Synthesis and Cytostatic Activity of Geiparvarin Analogues 96
Effects of chemically modified tetracyclines (CMTs) in sensitive, multidrug resistant and apoptosis resistant leukaemia cell lines 95
Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells 95
Regio - and enantioselective bioreduction of ethyl 2,4-dioxoalkanoates and γ-Keto-α-enamino esters with fermenting baker's yeast 95
A PLE-based resolution of cocaine, pseudococaine and 6-and 7-methoxylated cocaine analogues 95
Asymmetric synthesis of a β-ketol moiety via 3,5-disubstituted isoxazoles: Application to (+)-(S)-[6]-gingerol 94
3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis and evaluation for antimicrobial and antiviral activity. III. 92
Isoxazole-mediated synthesis of geiparvarin and dihydrogeiparvarin 91
L’1,2-Dimetil-4-ossimino-3,5-pirazolidindione come attivatore nella sintesi peptidica 91
Synthesis and evaluation of the antifungal activity of a new class of N-acylureas 90
Pig liver esterase (PLE)-mediated resolution of N-substituted 4-benzoyloxy-3-carbomethoxypiperidines: a convenient preparation of 4-hydroxy- and 4-benzoyloxy-3-carbomethoxypiperidines in enantiomerically pure form 89
Tyrosine kinase ihibitors for the treatment of chronic myeloid leukemia 89
Totale 12.471
Categoria #
all - tutte 73.745
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 403
Totale 74.148


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.491 0 0 0 0 0 0 296 340 279 388 126 62
2020/20212.213 181 225 130 228 65 235 65 249 49 283 300 203
2021/20221.818 67 127 129 107 186 88 71 83 86 94 162 618
2022/20231.678 169 109 57 207 307 261 40 159 215 12 82 60
2023/2024891 92 100 64 22 57 196 42 63 15 27 28 185
2024/20251.277 131 83 292 120 417 229 5 0 0 0 0 0
Totale 16.371