SIMONI, Daniele
 Distribuzione geografica
Continente #
NA - Nord America 16.493
AS - Asia 7.464
EU - Europa 5.958
SA - Sud America 1.101
Continente sconosciuto - Info sul continente non disponibili 194
AF - Africa 154
OC - Oceania 14
Totale 31.378
Nazione #
US - Stati Uniti d'America 16.159
SG - Singapore 2.740
FI - Finlandia 2.108
CN - Cina 1.973
BR - Brasile 854
DE - Germania 816
VN - Vietnam 791
UA - Ucraina 719
IT - Italia 635
TR - Turchia 617
HK - Hong Kong 586
GB - Regno Unito 483
SE - Svezia 332
FR - Francia 261
RU - Federazione Russa 193
CA - Canada 167
IN - India 146
JP - Giappone 126
PL - Polonia 113
BD - Bangladesh 111
MX - Messico 111
AR - Argentina 81
NL - Olanda 71
ZA - Sudafrica 62
ES - Italia 52
IQ - Iraq 46
PK - Pakistan 44
BE - Belgio 40
EC - Ecuador 39
ID - Indonesia 37
CO - Colombia 32
CL - Cile 31
PH - Filippine 31
MA - Marocco 29
SA - Arabia Saudita 26
LT - Lituania 25
AE - Emirati Arabi Uniti 22
PY - Paraguay 22
UZ - Uzbekistan 22
CZ - Repubblica Ceca 21
MY - Malesia 21
VE - Venezuela 20
KR - Corea 16
IE - Irlanda 14
AU - Australia 12
JO - Giordania 12
IR - Iran 11
RO - Romania 11
AT - Austria 10
CH - Svizzera 10
CR - Costa Rica 10
EG - Egitto 10
TW - Taiwan 10
EU - Europa 9
DZ - Algeria 8
IL - Israele 8
PE - Perù 8
TH - Thailandia 8
JM - Giamaica 7
KE - Kenya 7
TN - Tunisia 7
UY - Uruguay 7
AO - Angola 6
AZ - Azerbaigian 6
BH - Bahrain 6
ET - Etiopia 6
OM - Oman 6
RS - Serbia 6
SV - El Salvador 6
BG - Bulgaria 5
BO - Bolivia 5
LB - Libano 5
NI - Nicaragua 5
NO - Norvegia 5
NP - Nepal 5
PT - Portogallo 5
GT - Guatemala 4
HU - Ungheria 4
KZ - Kazakistan 4
PA - Panama 4
SN - Senegal 4
AL - Albania 3
BB - Barbados 3
BY - Bielorussia 3
CI - Costa d'Avorio 3
DO - Repubblica Dominicana 3
GA - Gabon 3
GE - Georgia 3
KG - Kirghizistan 3
KH - Cambogia 3
LV - Lettonia 3
PR - Porto Rico 3
SY - Repubblica araba siriana 3
TT - Trinidad e Tobago 3
A2 - ???statistics.table.value.countryCode.A2??? 2
BN - Brunei Darussalam 2
CY - Cipro 2
DM - Dominica 2
EE - Estonia 2
GR - Grecia 2
Totale 31.158
Città #
Helsinki 1.924
Singapore 1.808
Ashburn 1.640
Fairfield 1.464
Woodbridge 1.295
San Jose 1.044
Houston 902
Dallas 894
Jacksonville 775
Chandler 707
Seattle 664
Santa Clara 643
Ann Arbor 631
Beijing 586
Hong Kong 569
Wilmington 522
Cambridge 464
Council Bluffs 348
New York 269
Izmir 249
Ho Chi Minh City 248
Nanjing 242
Los Angeles 219
Hanoi 176
Princeton 157
Boardman 148
San Diego 139
Munich 137
Lauterbourg 128
Tokyo 114
Addison 102
The Dalles 99
Warsaw 92
São Paulo 88
Shanghai 87
Milan 83
Chicago 78
Shenyang 77
London 75
Mexico City 74
Nanchang 71
Hefei 63
Tianjin 61
Ferrara 59
Changsha 57
Hebei 57
Orem 55
Dong Ket 54
San Mateo 54
Frankfurt am Main 51
Toronto 47
Montreal 43
Jinan 42
Bremen 41
Chennai 41
Haiphong 40
Turku 40
Brussels 39
San Francisco 39
Bologna 38
Brooklyn 38
Phoenix 38
Buffalo 37
Amsterdam 35
Da Nang 35
Falkenstein 35
Atlanta 34
Denver 33
Jiaxing 33
Moscow 33
Falls Church 32
Philadelphia 32
Rio de Janeiro 30
Boston 29
Guangzhou 28
Johannesburg 25
Verona 25
Baghdad 24
Rome 24
Auburn Hills 21
Norwalk 21
Tashkent 20
Belo Horizonte 19
Brasília 19
Mountain View 19
Poplar 19
Stockholm 19
Manchester 18
Mumbai 18
Washington 18
Zhengzhou 18
Charlotte 17
Hangzhou 17
Jakarta 17
Kunming 17
Quito 17
Dearborn 16
Redwood City 16
Salt Lake City 16
Biên Hòa 15
Totale 21.930
Nome #
1,2,4-triazoles. Improved synthesis of 5-substituited 4-amino-3mercato-(4H)-1,2,4 triazoles and a facile route to 3,6-disubstituited 1,24-triazolo[3,4b][1,3,4]thiadiazoles 3.032
1,5,7-Triazabicyclo[4.4.0]dec-1-ene (TBD), 7-methyl-TBD (MTBD) and the polymer-supported TBD (P-TBD): Three efficient catalysts for the nitroaldol (Henry) reaction and for the addition of dialkyl phosphites to unsaturated systems 349
A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approach 303
A facile, efficient synthesis of 2-substituted-4-hydroxy-2-cyclopenten-1-ones 296
4,5,6,7-Tetrahydro-isoxazolo-[4,5-c]-pyridines as a new class of cytotoxic Hsp90 inhibitors 296
Effects of Pimozide Derivatives on pSTAT5 in K562 Cells 291
A [3+2] nitrile oxide intermolecular cycloaddition approach to 4,5-dihydro-3(2H)-furanone and 3(2H)-furanone ring systems: application to the formal synthesis of (±)-ascofuranone and geiparvarin. 287
Arylamidonaphtalene sulfonate compounds as a novel class of heparanase inhibitors 282
3,5-Disubstituted isoxazoles as a latent aldol moiety: Application to the synthesis of (±)-[6]-gingerol 280
Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitor 276
Retinoic acid conjugates as potential antitumor agents: Synthesis and biological activity of conjugates with Ara-A, Ara-C, 3(2H)-furanone, and aniline mustard moieties 274
Inhibition of activated STAT5 in Bcr/Abl expressing leukemia cells with new pimozide derivatives. 269
A convenient synthesis of unsymmetrically substituted terphenyls of biologically active stilbenes via a double Suzuki cross-coupling protocol 269
New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting 263
A [3 + 2] nitrile oxide cycloaddition approach to retinoids 262
3,5-Disubstituted Isoxazoles as Synthons for (±)-Pyrenophorin and (±)-Vermiculine Synthesis 257
A new nitrile oxide based synthesis of the antitumor agent geiparvarin 253
Design, synthesis and biological evaluation of novel stilbene-based antitumor agents 253
Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter 251
Hydropathic analysis and biological evaluation of stilbene derivatives as colchicine site microtubule inhibitors with anti-leukemic activity 251
Heterocyclic and phenyl double-bond-locked combretastatin analogues possessing potent apoptosis-inducing activity in HL60 and in MDR cell lines 249
Curcumin as a possible lead compound against hormone-independent, multidrug-resistant breast cancer 247
Novel terphenyls and 3,5-diaryl isoxazole derivatives endowed with growth supporting and antiapoptotic properties 246
A new direct glycosylation of pyrimidine, pyrazole, imidazole and purine heterocycles via their N-tetrahydropyranyl (THP) derivatives 242
Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growth 238
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation 236
Development of water soluble derivatives of cis-3, 4', 5-trimethoxy-3'- aminostilbene for optimization and use in cancer therapy 232
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity 227
A one-pot glycosylation of tetrahydropyranyl (THP) ether intermediates 226
Geiparvarin analogs. 2. Synthesis and cytostatic activity of 5-(4-arylbutadienyl)-3(2H)-furanones and of N-substituted 3-(4-oxo-2-furanyl)-2-buten-2-yl carbamates. 226
Methyl 4-oxothiolane-3-carboxylate and methyl 2-methyl-4-oxothiolane-3- carboxylate anions as synthetic equivalents of α-acrylate and α-crotonate anions. Formal synthesis of integerrinecic acid 220
Synthesis of 8-oxa analogues of norcocaine endowed with interesting cocaine-like activity 220
Synthesis and biological evaluation of resveratrol and analogues as apoptosis-inducing agents 220
Ethyl 2,4-dioxoalkanoates as starting materials for a convenient route to 3(2H)-furanones and 3(2H)-furanimines 219
Synthesis and pharmacology of 6-substituted benztropines: Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter 219
Antitumor effects of curcumin and structurally β-diketone modified analogs on multidrug resistant cancer cells 219
Stilbene 5c, a microtubule poison with vascular disrupting properties that induces multiple modes of growth arrest and cell death 218
Studies on the apoptotic activity of natural and synthetic retinoids: Discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells 216
Novel combretastatin analogues endowed with antitumor activity 216
The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: Analysis of the possible molecular basis 215
Lack of nucleophilic addition in the isoxazole and pyrazole diketone modified analogs of curcumin; implications for their antitumor and chemosensitizing activities 212
Cyclic guanidines: Synthesis of 4,6,7,8‐tetrahydro‐1H‐imidazo[1,2‐a]pyrazolo[3,4‐d]pyrimidin‐7‐ones and 1,4,6,7,8,9‐hexahydropyrazolo[3′,4′:4,5]pyrimido[2,1‐c] [1,2,4]triazin‐7‐ones 208
Synthesis and cytotoxic activity of 6-vinyl- and 6-ethynyluridine and 8-vinyl- and 8-ethynyladenosine 207
Preparation of 3,4-dihydroxy-1-benzeneethanol: a reinvestigation 206
Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici 206
Synthesis of syn- and anti-tricyclo [4.1.0.02,4] heptan-5-ones and related compounds 205
Geiparvarin Analogs. 4.1. Synthesis and Cytostatic Activity of Geiparvarin Analogs Bearing a Carbamate Moiety or a Furocoumarin Fragment on the Alkenyl Side Chain 204
Heterocycle-containing retinoids. Discovery of a novel isoxazole arotinoid possessing potent apoptotic activity in multidrug and drug-induced apoptosis-resistant cells. 204
Aryl and Heterocyclic Derivatives of Combretastatin A-4 Endowed with Anticancer Properties 203
Geiparvarin Analogs. 3. Synthesis and cytostatic activity of 3(2H)-furanone and 4,5-dihydro-3(2H)-furanone congeners of geiparvarin, containing a geraniol-like fragment in the side chain 202
Antitumor effects of new synthetic isoxazole derivatives 199
Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a γδ-T lymphocytes-mediated activation mechanism 198
A practical entry to C18-constrained-E-ring analogues of methyllycaconitine (MLA): a concise new stereoselective approach to 8-oxa-decahydrolsoquinolines accompanied by a simple microwaves-assisted synthesis of the succinimidobenzoate appendage of MLA 198
Strong Bicyclic Guanidine Base-promoted Wittig and Horner-Wadsworth-Emmons Reactions 197
Enantioselective deprotonation of the 8-oxabicyclo[3.2.1]octan-3-one: Synthesis of 8-oxa-norcocaines and 8-oxa-pseudonorcocaines 197
Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells. 196
5-Phenyl-isoxazole-3-carboxamides modulating Hsp90 with antitumoral activities 196
Analoghi eterociclici dell’acido retinoico (eteroretinoidi) come potenziali agenti “anti-aging”. 195
Synthesis of 2-(5-substituted isoxazol-3-yl)-4-oxo-3-thiazolidinyl alkanoic acids 192
Sintesi di derivati pirazolici e pirazolo[4,3-d]pirimidonici. Nota II 191
3,6-Disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles: synthesis and evaluation for antimicrobial and antiviral activity. III. 190
A PLE-based resolution of cocaine, pseudococaine and 6-and 7-methoxylated cocaine analogues 189
L’1,2-Dimetil-4-ossimino-3,5-pirazolidindione come attivatore nella sintesi peptidica 188
Synthesis of 6‐substituted‐4,5‐dihydro‐3(2H)‐pyridazinones 187
Two-carbon bridge substituted cocaines: Enantioselective synthesis, attribution of the absolute configuration and biological activity of novel 6- and 7-methoxylated cocaines 186
Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells 185
Cis-3, 4′, 5-Trimethoxy-3′-aminostilbene disrupts tumor vascular perfusion without damaging normal organ perfusion 184
New synthetic isoxazole derivatives as potent inducer of fetal hemoglobin (HbF) in beta-thalassemia 184
5-Phenyl-isoxazole-3-carboxamides modulating HSP90 with antitumoral activities 183
Concise enantioselective synthesis and attribution of the absolute configuration of two-carbon bridge methoxylated cocaines and pseudococaines 183
Pig liver esterase (PLE)-mediated resolution of N-substituted 4-benzoyloxy-3-carbomethoxypiperidines: a convenient preparation of 4-hydroxy- and 4-benzoyloxy-3-carbomethoxypiperidines in enantiomerically pure form 182
Synthesis and reactivity of a stable precursor of 2-cyano-1,3-butadiene 181
Isoxazole-mediated synthesis of geiparvarin and dihydrogeiparvarin 180
Synthesis of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine and 1,2,3-triazolo[4,5-e]1,2,4-triazolo[1,5-c]pyrimidine displaying potent and selective activity as A2a adenosine receptor antagonists 180
Total Synthesis of (±) isoclovene 180
Facile synthesis of 2-nitroalkanols by Tetramethylguanidine (TMG)-catalyzed addition of primary nitroalkanes to aldehydes and alicyclic ketones 180
Synthesis and Prostaglandin-like Activity of 2-(trans-3-Hydroxy-1-octenyl)-3-indolheptanoic Acid 180
Synthesis of 1-phenyl-substituted 3-methyl-1H-pyrazolo[3,4-b]pyrazine-5,6-dicarboxylic acid diethyl esters. 178
Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells 178
A novel α-acrylate anion equivalent: A useful synthon for α-substituted acrylic esters 177
Synthesis of natural products via isoxazoles 176
Facile synthesis of pyrazoles and pyrroles via thermolysis of tetrazolo[1,5-b]pyridazines, tetrazolo[1,5-a]pyrimidines and tetrazolo[1,5-a]pyridines 176
Stereoselective synthesis of 8-aza-9,11-ethenoprostaglandin H1 175
Elaboration of the ωChain of 11 -Deoxyprostanoid Derivatives through Isoxazole Intermediates 173
Sintesi di derivati pirazolici e pirazolo[4,3-d]pirimidonici. Nota I 173
Pyrazole-Related Nucleosides. Synthesis and Antiviral/Antitumor Activity of Some Substituted Pyrazole and Pyrazolo[4,3-d]-1,2,3-triazin-4-one Nucleosides 171
ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis 171
Versatile Synthesis of New Cytotoxic Agents Structurally Related to Emiasterlins 169
Pro‑apoptotic activity of novel synthetic isoxazole derivatives exhibiting inhibitory activity against tumor cell growth in vitro 169
Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogs of pyrrolo[1,4]benzodiazepines (PBDs) 168
Brain receptor binding of analogues of gamma-aminobutyric acid (GABA) 167
Facile access to 2'-O-acyl prodrugs of 1-(β-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2',3',5'-triesters 165
Regio - and enantioselective bioreduction of ethyl 2,4-dioxoalkanoates and γ-Keto-α-enamino esters with fermenting baker's yeast 164
Ethyl 5-substituted-3-isoxazole carboxvyates as starting materials for a convenient route to 3(2H )-furanones and 3(2H )-iminofuranes 162
The synergistic apoptotic effects of thiophenfurin, an inosine monophosphate dehydrogenase inhibitor, in combination with retinoids in HL60 cells 162
Synthesis of an 11-Deoxy-8-azaprostaglandin E1 Intermediate 161
Synthesis and Antitumor Activity of a New Class of Pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone Analogs of Pyrrolo[1,4][2,1-c]benzodiazepines 161
Mechanism of cell death induced by cis-3, 4′, 5-trimethoxy-3′-aminostilbene in ovarian cancer 160
Stilbene-based anticancer agents: Resveratrol analogues active toward HL60 leukemic cells wit a non-specific phase mechanism 159
Synthesis of 5-Hydroxy-2-oxotetrahydropyrroles 158
Totale 23.856
Categoria #
all - tutte 129.184
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 740
Totale 129.924


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.605 0 0 127 106 184 86 71 82 84 93 161 611
2022/20231.649 166 107 57 203 301 254 40 157 211 12 82 59
2023/2024877 91 98 64 22 56 194 40 59 15 26 28 184
2024/20253.170 130 78 289 117 412 225 69 196 428 348 532 346
2025/202612.133 989 555 1.308 1.236 1.440 735 1.124 491 2.691 1.085 341 138
2026/20271.169 268 537 364 0 0 0 0 0 0 0 0 0
Totale 31.378