Pig liver esterase (PLE) afforded smooth chemical resolution of racemic N-substituted 4-(benzoyloxy)- 3-carbomethoxypiperidines. The enzyme showed good chemo- and enantioselective properties, thus allowing discrimination between the carbomethoxy and benzoate ester groups, the latter being more easily hydrolyzed. The proposed methodology also represents a practical means for the procurement of N-substituted 4-hydroxy-3-carbomethoxypiperidines in enantiomerically pure form.

Pig liver esterase (PLE)-mediated resolution of N-substituted 4-benzoyloxy-3-carbomethoxypiperidines: a convenient preparation of 4-hydroxy- and 4-benzoyloxy-3-carbomethoxypiperidines in enantiomerically pure form

RONDANIN, Riccardo;FERRONI, Roberto;BARUCHELLO, Riccardo;BERTOLASI, Valerio;SIMONI, Daniele
2000

Abstract

Pig liver esterase (PLE) afforded smooth chemical resolution of racemic N-substituted 4-(benzoyloxy)- 3-carbomethoxypiperidines. The enzyme showed good chemo- and enantioselective properties, thus allowing discrimination between the carbomethoxy and benzoate ester groups, the latter being more easily hydrolyzed. The proposed methodology also represents a practical means for the procurement of N-substituted 4-hydroxy-3-carbomethoxypiperidines in enantiomerically pure form.
2000
Roberti, M; Rondanin, Riccardo; Ferroni, Roberto; Baruchello, Riccardo; Invidiata, Fp; Andrisano, V; Bertucci, C; Bertolasi, Valerio; Grimaudo, S; Tol...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1198161
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