The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.

A PLE-based resolution of cocaine, pseudococaine and 6-and 7-methoxylated cocaine analogues

SIMONI, Daniele;BARALDI, Pier Giovanni;LAMPRONTI, Ilaria;MANFREDINI, Stefano
1996

Abstract

The enzymatic hydrolysis of racemic cocaine and cocaine analogues using pig liver esterase (PLE) is shown to afford a practical means for achieving their chemical resolution. This reaction was found to proceed not only with good enantioselectivity, but with an interesting chemoselectivity as well.
Kozikowski, A. P.; Simoni, Daniele; Baraldi, Pier Giovanni; Lampronti, Ilaria; Manfredini, Stefano
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1685221
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