PRETI, Delia
 Distribuzione geografica
Continente #
NA - Nord America 14.889
EU - Europa 8.533
AS - Asia 6.805
SA - Sud America 1.265
Continente sconosciuto - Info sul continente non disponibili 223
AF - Africa 162
OC - Oceania 9
Totale 31.886
Nazione #
US - Stati Uniti d'America 14.540
FI - Finlandia 4.008
SG - Singapore 2.329
CN - Cina 1.773
DE - Germania 1.404
BR - Brasile 987
IT - Italia 932
VN - Vietnam 843
HK - Hong Kong 576
UA - Ucraina 508
TR - Turchia 428
GB - Regno Unito 424
RU - Federazione Russa 357
SE - Svezia 253
FR - Francia 233
CA - Canada 178
BD - Bangladesh 157
JP - Giappone 143
IN - India 142
PL - Polonia 119
AR - Argentina 110
MX - Messico 106
ID - Indonesia 83
ZA - Sudafrica 67
IQ - Iraq 58
NL - Olanda 58
ES - Italia 50
PK - Pakistan 47
BE - Belgio 45
EC - Ecuador 38
CO - Colombia 36
UZ - Uzbekistan 27
SA - Arabia Saudita 22
CL - Cile 21
MA - Marocco 21
VE - Venezuela 21
LT - Lituania 20
KR - Corea 19
MY - Malesia 19
CZ - Repubblica Ceca 18
IL - Israele 18
JM - Giamaica 17
UY - Uruguay 17
KE - Kenya 16
PY - Paraguay 16
AT - Austria 15
IE - Irlanda 15
PH - Filippine 15
PE - Perù 14
CR - Costa Rica 13
TN - Tunisia 13
AE - Emirati Arabi Uniti 12
EG - Egitto 12
SK - Slovacchia (Repubblica Slovacca) 11
TH - Thailandia 11
JO - Giordania 10
KZ - Kazakistan 10
PT - Portogallo 10
DZ - Algeria 9
NP - Nepal 9
AZ - Azerbaigian 8
TW - Taiwan 8
AU - Australia 7
EU - Europa 6
AL - Albania 5
BO - Bolivia 5
GR - Grecia 5
GT - Guatemala 5
HN - Honduras 5
HR - Croazia 5
IR - Iran 5
LV - Lettonia 5
MD - Moldavia 5
AO - Angola 4
BH - Bahrain 4
CH - Svizzera 4
KG - Kirghizistan 4
NI - Nicaragua 4
PS - Palestinian Territory 4
RS - Serbia 4
BG - Bulgaria 3
GA - Gabon 3
GH - Ghana 3
HU - Ungheria 3
NG - Nigeria 3
OM - Oman 3
PA - Panama 3
PR - Porto Rico 3
QA - Qatar 3
TT - Trinidad e Tobago 3
BA - Bosnia-Erzegovina 2
BS - Bahamas 2
BY - Bielorussia 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
ET - Etiopia 2
KH - Cambogia 2
KW - Kuwait 2
LB - Libano 2
MN - Mongolia 2
Totale 31.635
Città #
Helsinki 3.819
Dallas 1.758
Singapore 1.530
Ashburn 1.484
Fairfield 1.102
San Jose 1.037
Woodbridge 1.037
Ann Arbor 606
Houston 567
Beijing 566
Hong Kong 551
Santa Clara 551
Jacksonville 534
Chandler 500
Seattle 439
Wilmington 404
Council Bluffs 379
Cambridge 338
Ferrara 298
Ho Chi Minh City 250
New York 205
Munich 204
Los Angeles 200
Hanoi 193
Izmir 184
Nanjing 154
Princeton 131
Tokyo 131
Boardman 122
Milan 115
Lauterbourg 112
San Diego 112
Shanghai 110
Warsaw 103
São Paulo 93
Turku 76
Dong Ket 64
Orem 64
Mexico City 62
Chicago 58
Bremen 57
Montreal 56
Bologna 54
London 54
Hefei 51
Nanchang 51
Shenyang 50
Toronto 50
Tianjin 49
Brooklyn 48
Frankfurt am Main 48
Atlanta 45
Brussels 45
Jakarta 45
Phoenix 45
Rome 45
Falkenstein 40
Rio de Janeiro 39
Johannesburg 38
Chennai 37
Changsha 36
Dearborn 36
Da Nang 34
Denver 34
Buffalo 33
Philadelphia 32
San Mateo 32
Hebei 30
Poplar 29
Boston 27
Falls Church 27
Jiaxing 27
Redwood City 27
Amsterdam 26
Guangzhou 26
Haiphong 26
Moscow 26
Mountain View 25
Brasília 24
San Francisco 24
Tashkent 24
Baghdad 23
Stockholm 23
Washington 23
Ankara 22
Belo Horizonte 22
The Dalles 22
Manchester 21
Addison 20
Zhengzhou 20
Mumbai 19
Curitiba 18
Memphis 17
Dublin 16
Hải Dương 16
Jinan 16
Kunming 16
Biên Hòa 15
Columbus 15
Guarulhos 15
Totale 22.154
Nome #
1,3-Dipropyl-8-(1-phenylacetamide-1H-pyrazol-3-yl)-xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists 3.126
1,3,8-Triazaspiro compounds and their use as medicaments for the treatment of reperfusion injury. 2.967
Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction 343
A3 adenosine receptor antagonists: History and future perspectives 301
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor 288
7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: A promising approach for treating pain and inflammation 277
Synthesis and biological evaluation of 2-and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization 272
7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB2 Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists 263
[H-3]-MRE 2029-F20, a selective antagonist radioligand for the human A(2B) adenosine receptors 262
N-6-[(Hetero)aryl/(cyclo)alkyl-carbamoyi-methoxy-phenyl]-(2chloro)-5 '-N-ethylearboxamido-adenosines: The first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor 255
Structure-and conformation-Activity studies of nociceptin/orphanin FQ receptor dimeric ligands 254
Pyrazolo [4,3-e][1,2,4]triazolo[1,5-c]pyrimidine template: Organic and medicinal chemistry approach 252
Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH2 252
Naphthoquinone amino acid derivatives, synthesis and biological activity as proteasome inhibitors 252
DNA minor groove binders as potential antitumor and antimicrobial agents 249
New 2-heterocyclyl-imidazo[2,1- i ]purin-5-one derivatives as potent and selective human A 3 adenosine receptor antagonists 249
Allosteric enhancers for A(1) adenosine receptor 248
History and perspectives of A2A adenosine receptor antagonists as potential therapeutic agents 248
Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents 245
New heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2. 243
C subunit of F1/FO-ATP synthase as target for preventing the detrimental effect of myocardial ischemia/reperfusion injury 243
Discovery of novel fetal hemoglobin inducers for β-thalassemia by small chemical library screening 239
The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice 239
Novel 8-heterocyclyl xanthine derivatives in drug development - An update 234
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles 230
From tyrosine to glycine: Synthesis and biological activity of potent antagonists of the purinergic P2X(7) receptor 229
Synthesis of a new series of pyrazolo[1,5-a]pyrimidines structurally related to zaleplon 229
Hybrid molecules between distamycin A and active moieties of antitumor agents 229
Neuropeptide S receptor ligands: a patent review (2005-2016) 228
Hybrid molecules based on distamycin A as potential antitumor agents 228
Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation 227
The involvement of the TRPA1 receptor in a mouse model of sympathetically maintained neuropathic pain 224
Synthesis and biological evaluation of 2-(3 ',4 ',5 '-trimethoxybenzoyl)-3-amino 5-aryl thiophenes as a new class of tubulin inhibitors 222
New heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2 221
Structure-activity relationship studies of a new series of imidazo[2,1-f] purinones as potent and selective A3 adenosine receptor antagonists 221
Adenosine modulates HIF-1, VEGF, IL-8 and foam cells formation in a human model of hypoxic foam cells 221
Design, synthesis, and biological evaluation of new 8-heterocyclic xanthine derivatives as highly potent and selective human A(2B) adenosine receptor antagonists 220
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and linked Heterocycles as template for the adenosine receptor antagonism: Medicinal chemistry approach and sar considerations 219
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain 219
Microwave-assisted synthesis of thieno[2,3-c]pyridine derivatives as a new series of allosteric enhancers at the adenosine A(1) receptor 218
Recent improvements in the development of A2B adenosine receptor agonists 217
Discovery and Optimization of a Series of 2-Aryl-4-Amino-5-(3 ',4 ',5 '-trimethoxybenzoyl)Thiazoles as Novel Anticancer Agents 216
Structure-activity relationships around the KN-62, a potent antagonist of the P2X(7)receptor 215
The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives 215
Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4’-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene 214
Synthesis and Biological Activity of Peptide α-Ketoamide Derivatives as Proteasome Inhibitors 214
Design, synthesis and growth inhibition activity of bis-epoxyethyl derivatives of stallimycin modified on the amidino moiety 213
Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer 210
Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach 210
Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxyphenylsulfonyl)-5-aryl thiophenes as a new class of antitubulin agents 209
Water-Soluble Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as Human A3 Adenosine Receptor Antagonists 209
Recent improvements in the development of A2B adenosine receptor agonists 208
Recent developments in the field of adenosine receptor ligands. 206
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents 206
Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies 206
New pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A(3) adenosine receptor antagonists 204
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N- (substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor 204
Synthesis and Biological Evaluation of 1-Methyl-2-(3’,4’,5’-Trimethoxybenzoyl)-3-Amino Indoles as a New Class of Antimitotic Agents and Tubulin Inhibitors 202
Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and Mu Opioid Receptors 202
Recent developments in the field of A(2A) and A(3) adenosine receptor antagonists 201
Adenosine in a human model of Hypoxic foam cells 200
New 2-arylpyrazolo[4,3-c]quinoline derivatives as potent and selective human A(3) adenosine receptor antagonists 198
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4- arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor 198
Microwave-assisted synthesis of substituted 2,4-diarylthiazoles and their evaluation as anticancer agents 195
New strategies for the synthesis of A(3) adenosine receptor antagonists 195
Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and alpha-bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells 194
alpha-Halogenoacrylic Derivatives of Antitumor Agents 193
Adenosine modulates HIF-1α, VEGF, IL-8, and foam cell formation in a human model of hypoxic foam cells 191
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system 191
Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice 188
Ozone-induced hypertussive responses in rabbits and guinea pigs 187
New 2-arylpyrazolo[4,3-c]quinoline derivates as potent and selective human A3 adenosine receptor antagonists 186
Bifunctional octadentate pseudopeptides as Zirconium-89 chelators for immuno-PET applications 184
Design, synthesis, and biological evaluation of C-9- and C-2-substituted pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c] pyrimidines as new A(2A) and A(3) adenosine receptors antagonists 182
Preparation of fused purine derivatives as adenosine A3 receptor modulators. 179
Medicinal Chemistry of A3 Adenosine Receptor Modulators: Pharmacological Activities and Therapeutic Implications 179
Synthesis and biological evaluation of 2-aroyl-4-phenyl-5-hydroxybenzofurans as a new class of antitubulin agents 179
Novel Mixed NOP/Opioid Receptor Peptide Agonists 178
Synthesis and biological evaluation of novel N-6-[4-(substituted) sulfonamidophenylcarbamoyl]adenosine-5 '-uronamides as A(3) adenosine receptor agonists 177
Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents 176
Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents 176
Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors 175
Recent improvements in the field of A(3) adenosine receptor ligands 173
Synthesis and biological evaluation of 2-substituted-4-(3 ',4 ',5 '-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents 172
Preparation of fused purine derivatives as adenosine A3 receptor modulators. 171
The acyl-glucuronide metabolite of ibuprofen has analgesic and anti-inflammatory effects via the TRPA1 channel 171
COMPOSTI 1,3,8-TRIAZASPIRO E LORO USO COME MEDICAMENTI 170
Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity 170
COMPOSTI PIRROLIDINICI E PIPERIDINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 167
The P2X7 receptor as a therapeutic target 165
Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1- yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A 1 adenosine receptor 165
TRP channels as therapeutic targets in airway disorders: a patent review 165
Ligands for A(2B) adenosine receptor subtype 164
New pyrrolo [2,1-f] purine-2,4-dione and Imidazo[2,1-f]purine-2,4-dione derivates as potent and selective human A3 adenosine receptor antagonists 161
Design, synthesis and biological evaluation of hybrid molecules containing conjugated styryl ketone and α-bromoacryloyl moieties 161
Compounds as nlrp3 inflammasome inhibitors and their use as medicaments 159
COMPOSTI SOLFONAMMIDICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 158
Pyrrolo- and pyrazolo-[3,4-e][1,2,4]triazolo[1,5-c]pyrimidines as adenosine receptor antagonists 155
Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase 154
Spiropiperidine-Based Oligomycin-Analog Ligands To Counteract the Ischemia–Reperfusion Injury in a Renal Cell Model 146
Totale 26.615
Categoria #
all - tutte 116.178
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 2.715
Totale 118.893


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.176 0 0 137 55 88 61 84 57 47 105 140 402
2022/20231.270 132 86 23 181 239 171 53 92 169 9 64 51
2023/2024831 59 96 49 25 60 137 41 90 25 19 22 208
2024/20253.344 85 99 271 144 350 322 103 194 474 348 494 460
2025/202615.001 975 962 2.043 1.139 1.350 682 1.077 514 4.551 1.135 402 171
2026/20271.391 389 549 453 0 0 0 0 0 0 0 0 0
Totale 31.886