Chemonociception represents an important signaling mechanism of acute pain, but it may also contribute to persistent pain, especially in the context of peripheral tissue injury and inflammation. The primary role of TRPA1 as a general and non-specific sensor of a variety of chemical species, generated by diverse enzymatic or non-enzymatic proinflammatory pathways, underlines the hypothesis that compounds that block channel activity represent a new class of analgesic medicine. The emerging role of neuronal TRPA1 in the orchestration of the inflammatory response in animal models of airway diseases, including asthma and COPD is of much interest and TRPA1 antagonists could be regarded as novel antitussive medicines.
Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as Emerging Target for Novel Analgesics and Anti-Inflammatory Agents
BARALDI, Pier Giovanni;PRETI, Delia;
2010
Abstract
Chemonociception represents an important signaling mechanism of acute pain, but it may also contribute to persistent pain, especially in the context of peripheral tissue injury and inflammation. The primary role of TRPA1 as a general and non-specific sensor of a variety of chemical species, generated by diverse enzymatic or non-enzymatic proinflammatory pathways, underlines the hypothesis that compounds that block channel activity represent a new class of analgesic medicine. The emerging role of neuronal TRPA1 in the orchestration of the inflammatory response in animal models of airway diseases, including asthma and COPD is of much interest and TRPA1 antagonists could be regarded as novel antitussive medicines.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
