Extracellular adenosine and adenine nucleotides induce various cellular responses through activation of P1 and P2 receptors. P1 receptors preferentially recognize adenosine and four different G protein-coupled receptors (A1, A2A, A2B, and A3 subtypes) have been identified. On the other hand, P2 receptors are activated by adenine and/or uridine nucleotides and classified into two families: ionotropic P2X and G protein-coupled P2Y receptors. In this article, we summarize our studies which led to development of new potent and selective heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2X7.

New heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2.

BARALDI, Pier Giovanni;ROMAGNOLI, Romeo;AGHAZADEH TABRIZI, Mojgan;BOVERO, Andrea;PRETI, Delia;FRUTTAROLO, Francesca;BOREA, Pier Andrea
2005

Abstract

Extracellular adenosine and adenine nucleotides induce various cellular responses through activation of P1 and P2 receptors. P1 receptors preferentially recognize adenosine and four different G protein-coupled receptors (A1, A2A, A2B, and A3 subtypes) have been identified. On the other hand, P2 receptors are activated by adenine and/or uridine nucleotides and classified into two families: ionotropic P2X and G protein-coupled P2Y receptors. In this article, we summarize our studies which led to development of new potent and selective heterocyclic ligands for the adenosine receptors P1 and for the ATP receptors P2X7.
2005
Baraldi, Pier Giovanni; Romagnoli, Romeo; AGHAZADEH TABRIZI, Mojgan; Bovero, Andrea; Preti, Delia; Fruttarolo, Francesca; Moorman, Ar; Borea, Pier And...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/519023
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