Adenosine A3 receptor modulators of formula I [X = CH or N; R1, R2 = (un)substituted alkyl, aralkyl, aryl, etc.; R3 = (un)substituted aryl, alkyl, aralkyl; R4 = H, (un)substituted alkyl, aralkyl, aryl] are prepd. These compds. are useful as therapeutic agents for a no. of diseases and medical conditions that are mediated by the A3 receptor. The compds. of this invention are also useful as diagnostic agents for the A3 receptor. Thus, II was prepd., starting from benzylurea and 2-cyanoacetic acid, and had Ki value of 200 nM for binding to A3 receptors expressed in CHO cells.
Preparation of fused purine derivatives as adenosine A3 receptor modulators.
BARALDI, Pier Giovanni;BOREA, Pier Andrea;PRETI, Delia;AGHAZADEH TABRIZI, Mojgan
2008
Abstract
Adenosine A3 receptor modulators of formula I [X = CH or N; R1, R2 = (un)substituted alkyl, aralkyl, aryl, etc.; R3 = (un)substituted aryl, alkyl, aralkyl; R4 = H, (un)substituted alkyl, aralkyl, aryl] are prepd. These compds. are useful as therapeutic agents for a no. of diseases and medical conditions that are mediated by the A3 receptor. The compds. of this invention are also useful as diagnostic agents for the A3 receptor. Thus, II was prepd., starting from benzylurea and 2-cyanoacetic acid, and had Ki value of 200 nM for binding to A3 receptors expressed in CHO cells.File in questo prodotto:
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