Although still used by hundreds of millions of people worldwide, the mechanism of the analgesic action of the pyrazolone derivatives (PDs), dipyrone, propyphenazone and antipyrine remains unknown. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed by nociceptors, is emerging as a major pain transduction pathway. We hypothesized that PDs target the TRPA1 channel and by this mechanism produce their analgesic effect.

The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

PRETI, Delia;
2015

Abstract

Although still used by hundreds of millions of people worldwide, the mechanism of the analgesic action of the pyrazolone derivatives (PDs), dipyrone, propyphenazone and antipyrine remains unknown. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed by nociceptors, is emerging as a major pain transduction pathway. We hypothesized that PDs target the TRPA1 channel and by this mechanism produce their analgesic effect.
2015
Nassini, Romina; Fusi, Camilla; Materazzi, Serena; Coppi, Elisabetta; Tuccinardi, Tiziano; Marone, Ilaria M; De Logu, Francesco; Preti, Delia; Tonello, Raquel; Chiarugi, Alberto; Patacchini, Riccardo; Geppetti, Pierangelo; Benemei, Silvia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2329487
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