PACIFICO, Salvatore
 Distribuzione geografica
Continente #
NA - Nord America 6.431
AS - Asia 3.433
EU - Europa 2.294
SA - Sud America 559
Continente sconosciuto - Info sul continente non disponibili 223
AF - Africa 88
OC - Oceania 8
Totale 13.036
Nazione #
US - Stati Uniti d'America 6.258
SG - Singapore 1.301
IT - Italia 848
CN - Cina 739
VN - Vietnam 430
BR - Brasile 424
PL - Polonia 291
HK - Hong Kong 269
DE - Germania 247
GB - Regno Unito 157
BD - Bangladesh 142
FI - Finlandia 133
TR - Turchia 116
UA - Ucraina 110
FR - Francia 108
JP - Giappone 108
CA - Canada 98
RU - Federazione Russa 82
IN - India 80
ID - Indonesia 74
SE - Svezia 57
IE - Irlanda 55
NL - Olanda 52
AR - Argentina 48
MX - Messico 48
ZA - Sudafrica 38
ES - Italia 32
BE - Belgio 26
PK - Pakistan 24
IQ - Iraq 22
AT - Austria 19
CZ - Repubblica Ceca 19
EC - Ecuador 19
CO - Colombia 18
UZ - Uzbekistan 18
SA - Arabia Saudita 15
VE - Venezuela 13
CL - Cile 12
JO - Giordania 12
PH - Filippine 12
LT - Lituania 11
AE - Emirati Arabi Uniti 10
PE - Perù 10
EG - Egitto 8
KR - Corea 8
PY - Paraguay 8
KE - Kenya 7
TN - Tunisia 7
CH - Svizzera 6
CR - Costa Rica 6
DZ - Algeria 6
IL - Israele 6
JM - Giamaica 6
KZ - Kazakistan 6
MY - Malesia 6
NP - Nepal 6
AL - Albania 5
IR - Iran 5
MA - Marocco 5
UY - Uruguay 5
AU - Australia 4
AZ - Azerbaigian 4
BG - Bulgaria 4
DK - Danimarca 4
HU - Ungheria 4
NG - Nigeria 4
PT - Portogallo 4
AO - Angola 3
DO - Repubblica Dominicana 3
EU - Europa 3
GR - Grecia 3
NO - Norvegia 3
NZ - Nuova Zelanda 3
PA - Panama 3
PS - Palestinian Territory 3
RO - Romania 3
SN - Senegal 3
TH - Thailandia 3
BY - Bielorussia 2
ET - Etiopia 2
GA - Gabon 2
GT - Guatemala 2
KG - Kirghizistan 2
KW - Kuwait 2
LY - Libia 2
MD - Moldavia 2
PR - Porto Rico 2
AM - Armenia 1
BH - Bahrain 1
BJ - Benin 1
BO - Bolivia 1
BS - Bahamas 1
BT - Bhutan 1
CY - Cipro 1
EE - Estonia 1
GD - Grenada 1
GE - Georgia 1
GY - Guiana 1
HR - Croazia 1
LA - Repubblica Popolare Democratica del Laos 1
Totale 12.803
Città #
Ashburn 884
Singapore 807
San Jose 626
Fairfield 480
Woodbridge 375
Ferrara 296
Beijing 276
Warsaw 274
Hong Kong 260
Santa Clara 258
Ann Arbor 241
Houston 238
Chandler 212
Seattle 196
Dallas 183
Cambridge 177
Ho Chi Minh City 164
Los Angeles 163
Wilmington 154
New York 146
Jacksonville 123
Council Bluffs 120
Munich 116
Menlo Park 98
Tokyo 95
Hanoi 92
Bologna 79
Milan 71
Jakarta 61
Helsinki 59
Lauterbourg 56
Princeton 55
Shanghai 51
São Paulo 48
Izmir 46
Nanjing 43
Turku 40
Chicago 37
Buffalo 35
Montreal 33
Atlanta 32
Brooklyn 30
Toronto 30
Rome 29
San Diego 29
Orem 27
London 26
Brussels 25
Frankfurt am Main 25
Mexico City 25
Addison 24
St Louis 24
Johannesburg 22
Chennai 21
Da Nang 21
Phoenix 21
San Francisco 21
Nanchang 20
Poplar 20
Boardman 19
The Dalles 19
Boston 18
Dearborn 18
Tashkent 18
Dublin 17
Moscow 17
Amsterdam 15
Belo Horizonte 15
Charlotte 15
Denver 15
Dong Ket 15
Manchester 15
Nuremberg 15
Ankara 14
Lappeenranta 14
Naples 14
Ferrara di Monte Baldo 13
Haiphong 13
Piscataway 13
Redwood City 13
Falkenstein 12
Padova 12
Rio de Janeiro 12
Secaucus 12
Amman 11
Guangzhou 11
Lahore 11
Mountain View 11
Stockholm 11
Vienna 11
Brasília 10
Brno 10
Cagliari 10
Columbus 10
Falls Church 10
Hefei 10
Norwalk 10
Washington 10
Bremen 9
Changsha 9
Totale 8.777
Nome #
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer’s disease 338
Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction 326
Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones 302
A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism 297
Sintesi di glicopeptidi mediante le reazioni tiol-ene/ino e studio della reattività di Umpolung di α-dichetoni 282
Expeditious Synthesis and Biological Characterization of Enantio-Enriched (-)-Nutlin-3 274
Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH2 244
Structure-and conformation-Activity studies of nociceptin/orphanin FQ receptor dimeric ligands 244
Structure activity studies of nociceptin/orphanin FQ(1–13)-NH2 derivatives modified in position 5 243
Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19 232
Discovery of novel fetal hemoglobin inducers for β-thalassemia by small chemical library screening 231
Modulation of the NOP receptor signaling affects resilience to acute stress 230
Peptide welding technology – A simple strategy for generating innovative ligands for G protein coupled receptors 230
Neuropeptide S receptor ligands: a patent review (2005-2016) 221
Activation of nociceptin/orphanin FQ receptors inhibits contextual fear memory reconsolidation 220
One-pot, two-step desymmetrization of symmetrical benzils catalyzed by the methylsulfinyl (dimsyl) anion 216
alpha-Diketones as acyl anion equivalents: a non-enzymatic thiamine-promoted route to aldehyde ketone coupling in PEG(400) as recyclable medium 212
Synthesis and Biological Activity of Peptide α-Ketoamide Derivatives as Proteasome Inhibitors 209
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 206
Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones 206
Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease 202
Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer 194
Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and Mu Opioid Receptors 194
Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects 192
Photoinduced addition of glycosyl thiols to alkynyl peptides: use of free-radical thiol-yne coupling for post-translational double-glycosylation of peptides 190
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 187
Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2 184
alpha-Diketones as acyl anion equivalents: new enzymatic and non-enzymatic thiamine-promoted routes to aldehyde-ketone coupling 177
Synthesis of S-glycosyl amino acids and S-glycopeptides via photoinduced click thiol-ene coupling 177
Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors 172
Novel Mixed NOP/Opioid Receptor Peptide Agonists 172
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 171
Bifunctional octadentate pseudopeptides as Zirconium-89 chelators for immuno-PET applications 169
Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor 168
Synthesis and evaluation of antioxidant and antiproliferative activity of 2-arylbenzimidazoles 165
The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation 165
Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity 162
COMPOSTI PIRROLIDINICI E PIPERIDINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 159
Serum beta-secretase 1 (BACE1) activity increases in patients with mild cognitive impairment 156
Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists 153
COMPOSTI SOLFONAMMIDICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 152
Age, Sex, Hypertension and HDL-C Alter Serum BACE1 Activity in Cognitively Normal Subjects: Implications for Alzheimer's Disease 152
Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells 151
Compounds as nlrp3 inflammasome inhibitors and their use as medicaments 149
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 149
Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase 147
Cyclic peptides acting as allosteric inhibitors of human thymidylate synthase and cancer cell growth 145
Effects of non-peptide nociceptin/orphanin FQ receptor ligands on methylphenidate-induced hyperactivity in mice: Implications for bipolar disorders 143
In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative 142
Probing non-peptide agonists binding at the human nociceptin/orphanin FQ receptor: a molecular modelling study 140
Thermodynamic Stability and Speciation of Ga(III) and Zr(IV) Complexes with High-Denticity Hydroxamate Chelators 137
Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines 135
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 134
Thiazolium-catalyzed intermolecular Stetter reaction of linear and cyclic alkyl α-diketones 132
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 130
Thiazolium-functionalized polystyrene monolithic microreactors for continuous-flow umpolung catalysis 122
COMPOSTI TETRAIDROISOCHINOLINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 117
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 116
In vitro pharmacological evaluation of the novel NOP receptor partial agonist sunobinop 116
Sex differences in response to NLRP3 inflammasome blockage in a mouse migraine model: A genetic and pharmacological study 115
FAP inhibitors: are we really using the best method to evaluate the residence time? 114
Identification of isoxazole-based TRPA1 inhibitors with analgesic effects in vivo 114
Reactivity of dialkyl and diaryl alpha-diketones with N-heterocyclic carbenes 110
null 110
null 108
Dimethyl Sulfoxide and N,N-dimethylformamide as Umpolung Pre-catalysts in Cross Benzoin Reactions of alpha-Diketones with Aldehydes 107
Probing the Effect of Sildenafil on Progesterone and Testosterone Production by an Intracellular FRET/BRET Combined Approach 106
Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line 98
Thiazolium-Functionalized Polystyrene Monolithic Microreactors for Continuous-Flow Umpolung Catalysis 94
null 94
null 92
Methylsulfinyl (Dimsyl) Anion as Umpolung Catalyst for the Chemoselective Cross Benzoin Reaction of α-Diketones with Aldehydes 90
Synthesis and Pharmacological Characterization of Nociceptin/Orphanin FQ Dimeric Ligands 86
Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics 85
Thermodynamic and spectroscopic analysis of peptide-based enzyme mimics containing the ATCUN site 83
null 79
Unexpected reactivity of diaryl α-diketones with thiazolium carbenes: discovery of a novel multicomponent reaction for the facile synthesis of 1,4-thiazin-3-ones 70
Synthesis of Chiral Ionic Liquids from Natural Monosaccharides 68
Thermodynamic and spectroscopic analysis of peptide-based enzyme mimics containing the ATCUN site 57
null 57
Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits 18
Totale 13.036
Categoria #
all - tutte 57.934
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 57.934


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022690 31 91 147 32 27 33 43 26 33 51 34 142
2022/2023522 57 61 12 60 73 53 49 45 55 3 39 15
2023/2024481 50 47 24 25 25 81 25 47 22 24 14 97
2024/20251.904 67 38 160 96 162 154 51 95 342 189 289 261
2025/20266.215 567 311 541 666 887 390 744 361 555 692 319 182
2026/2027265 265 0 0 0 0 0 0 0 0 0 0 0
Totale 13.036