PACIFICO, Salvatore
 Distribuzione geografica
Continente #
NA - Nord America 4.916
AS - Asia 2.427
EU - Europa 1.822
SA - Sud America 444
AF - Africa 53
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 3
Totale 9.669
Nazione #
US - Stati Uniti d'America 4.800
SG - Singapore 1.058
IT - Italia 616
CN - Cina 589
BR - Brasile 364
PL - Polonia 283
HK - Hong Kong 239
DE - Germania 231
VN - Vietnam 198
GB - Regno Unito 129
UA - Ucraina 104
TR - Turchia 103
FI - Finlandia 81
RU - Federazione Russa 78
ID - Indonesia 67
CA - Canada 63
SE - Svezia 55
IE - Irlanda 50
MX - Messico 42
FR - Francia 37
IN - India 37
AR - Argentina 33
NL - Olanda 33
ES - Italia 28
ZA - Sudafrica 28
JP - Giappone 27
BE - Belgio 24
BD - Bangladesh 23
CZ - Repubblica Ceca 19
AT - Austria 17
EC - Ecuador 12
IQ - Iraq 11
LT - Lituania 11
PK - Pakistan 9
UZ - Uzbekistan 9
AE - Emirati Arabi Uniti 8
PE - Perù 8
CL - Cile 7
KR - Corea 7
VE - Venezuela 7
CO - Colombia 6
JO - Giordania 6
KZ - Kazakistan 6
SA - Arabia Saudita 6
IR - Iran 5
NP - Nepal 5
PY - Paraguay 5
AL - Albania 4
BG - Bulgaria 4
DZ - Algeria 4
EG - Egitto 4
IL - Israele 4
KE - Kenya 4
MA - Marocco 4
AO - Angola 3
CH - Svizzera 3
CR - Costa Rica 3
EU - Europa 3
AU - Australia 2
AZ - Azerbaigian 2
DK - Danimarca 2
KW - Kuwait 2
PA - Panama 2
PT - Portogallo 2
RO - Romania 2
SN - Senegal 2
TN - Tunisia 2
AM - Armenia 1
BO - Bolivia 1
BS - Bahamas 1
BY - Bielorussia 1
DO - Repubblica Dominicana 1
GA - Gabon 1
GD - Grenada 1
GR - Grecia 1
GT - Guatemala 1
HU - Ungheria 1
JM - Giamaica 1
KG - Kirghizistan 1
LU - Lussemburgo 1
LV - Lettonia 1
MD - Moldavia 1
MK - Macedonia 1
MY - Malesia 1
NG - Nigeria 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
OM - Oman 1
PR - Porto Rico 1
QA - Qatar 1
SK - Slovacchia (Repubblica Slovacca) 1
TV - Tuvalu 1
TW - Taiwan 1
UY - Uruguay 1
Totale 9.669
Città #
Ashburn 634
Singapore 596
Fairfield 480
Woodbridge 374
Ferrara 272
Warsaw 270
Beijing 251
Ann Arbor 241
Hong Kong 235
Houston 229
Santa Clara 225
Chandler 212
Seattle 195
Cambridge 177
Dallas 176
Wilmington 154
Los Angeles 135
Jacksonville 120
Munich 116
New York 116
Menlo Park 98
Ho Chi Minh City 84
Jakarta 61
Bologna 60
Princeton 55
Milan 49
Shanghai 48
Izmir 45
Nanjing 41
São Paulo 40
Turku 40
Hanoi 32
Chicago 31
Brooklyn 29
Montreal 28
San Diego 28
Addison 24
Atlanta 24
Brussels 24
Mexico City 24
Tokyo 24
London 22
St Louis 22
Buffalo 20
Nanchang 20
Poplar 20
Boardman 19
Dearborn 18
Helsinki 18
Phoenix 18
Rome 18
The Dalles 18
Boston 17
Johannesburg 17
Moscow 17
Orem 17
San Francisco 17
Chennai 16
Frankfurt am Main 16
Denver 15
Dong Ket 15
Nuremberg 14
Belo Horizonte 13
Ferrara di Monte Baldo 13
Redwood City 13
Dublin 12
Falkenstein 12
Padova 12
Ankara 11
Charlotte 11
Mountain View 11
Rio de Janeiro 11
Stockholm 11
Brno 10
Columbus 10
Falls Church 10
Hefei 10
Norwalk 10
Toronto 10
Brasília 9
Bremen 9
Tashkent 9
Tianjin 9
Vienna 9
Cagliari 8
Des Moines 8
Guangzhou 8
Manchester 8
Calgary 7
Haiphong 7
Jinan 7
Olomouc 7
Pittsburgh 7
San Jose 7
San Mateo 7
Shenyang 7
Washington 7
Amman 6
Amsterdam 6
Bexley 6
Totale 6.819
Nome #
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer’s disease 303
A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism 260
Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones 253
Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction 252
Sintesi di glicopeptidi mediante le reazioni tiol-ene/ino e studio della reattività di Umpolung di α-dichetoni 248
Expeditious Synthesis and Biological Characterization of Enantio-Enriched (-)-Nutlin-3 232
Structure activity studies of nociceptin/orphanin FQ(1–13)-NH2 derivatives modified in position 5 206
Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH2 200
Structure-and conformation-Activity studies of nociceptin/orphanin FQ receptor dimeric ligands 198
Modulation of the NOP receptor signaling affects resilience to acute stress 197
One-pot, two-step desymmetrization of symmetrical benzils catalyzed by the methylsulfinyl (dimsyl) anion 188
Discovery of novel fetal hemoglobin inducers for β-thalassemia by small chemical library screening 178
Peptide welding technology – A simple strategy for generating innovative ligands for G protein coupled receptors 175
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 174
Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease 174
Activation of nociceptin/orphanin FQ receptors inhibits contextual fear memory reconsolidation 172
alpha-Diketones as acyl anion equivalents: a non-enzymatic thiamine-promoted route to aldehyde ketone coupling in PEG(400) as recyclable medium 171
Photoinduced addition of glycosyl thiols to alkynyl peptides: use of free-radical thiol-yne coupling for post-translational double-glycosylation of peptides 171
Neuropeptide S receptor ligands: a patent review (2005-2016) 170
Synthesis and Biological Activity of Peptide α-Ketoamide Derivatives as Proteasome Inhibitors 167
Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones 164
Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and Mu Opioid Receptors 156
Synthesis of S-glycosyl amino acids and S-glycopeptides via photoinduced click thiol-ene coupling 154
Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer 152
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 147
Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor 143
alpha-Diketones as acyl anion equivalents: new enzymatic and non-enzymatic thiamine-promoted routes to aldehyde-ketone coupling 142
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 142
Synthesis and evaluation of antioxidant and antiproliferative activity of 2-arylbenzimidazoles 139
Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19 135
The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation 135
Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2 132
Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects 130
Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity 126
Novel Mixed NOP/Opioid Receptor Peptide Agonists 117
Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells 116
Bifunctional octadentate pseudopeptides as Zirconium-89 chelators for immuno-PET applications 115
Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors 113
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 113
Age, Sex, Hypertension and HDL-C Alter Serum BACE1 Activity in Cognitively Normal Subjects: Implications for Alzheimer's Disease 110
null 110
Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists 110
Effects of non-peptide nociceptin/orphanin FQ receptor ligands on methylphenidate-induced hyperactivity in mice: Implications for bipolar disorders 109
Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase 108
null 108
In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative 108
Thiazolium-catalyzed intermolecular Stetter reaction of linear and cyclic alkyl α-diketones 107
Serum beta-secretase 1 (BACE1) activity increases in patients with mild cognitive impairment 106
Probing non-peptide agonists binding at the human nociceptin/orphanin FQ receptor: a molecular modelling study 103
Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines 103
Cyclic peptides acting as allosteric inhibitors of human thymidylate synthase and cancer cell growth 102
Thermodynamic Stability and Speciation of Ga(III) and Zr(IV) Complexes with High-Denticity Hydroxamate Chelators 97
COMPOSTI SOLFONAMMIDICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 95
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 95
null 94
null 92
Thiazolium-functionalized polystyrene monolithic microreactors for continuous-flow umpolung catalysis 89
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 89
Reactivity of dialkyl and diaryl alpha-diketones with N-heterocyclic carbenes 88
COMPOSTI PIRROLIDINICI E PIPERIDINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 85
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 81
Probing the Effect of Sildenafil on Progesterone and Testosterone Production by an Intracellular FRET/BRET Combined Approach 80
Dimethyl Sulfoxide and N,N-dimethylformamide as Umpolung Pre-catalysts in Cross Benzoin Reactions of alpha-Diketones with Aldehydes 79
null 79
COMPOSTI TETRAIDROISOCHINOLINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 76
Thiazolium-Functionalized Polystyrene Monolithic Microreactors for Continuous-Flow Umpolung Catalysis 74
Compounds as nlrp3 inflammasome inhibitors and their use as medicaments 74
FAP inhibitors: are we really using the best method to evaluate the residence time? 59
Identification of isoxazole-based TRPA1 inhibitors with analgesic effects in vivo 58
null 57
Methylsulfinyl (Dimsyl) Anion as Umpolung Catalyst for the Chemoselective Cross Benzoin Reaction of α-Diketones with Aldehydes 54
In vitro pharmacological evaluation of the novel NOP receptor partial agonist sunobinop 53
Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line 52
Unexpected reactivity of diaryl α-diketones with thiazolium carbenes: discovery of a novel multicomponent reaction for the facile synthesis of 1,4-thiazin-3-ones 51
Synthesis of Chiral Ionic Liquids from Natural Monosaccharides 48
Sex differences in response to NLRP3 inflammasome blockage in a mouse migraine model: A genetic and pharmacological study 37
Thermodynamic and spectroscopic analysis of peptide-based enzyme mimics containing the ATCUN site 37
Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics 36
Synthesis and Pharmacological Characterization of Nociceptin/Orphanin FQ Dimeric Ligands 20
Thermodynamic and spectroscopic analysis of peptide-based enzyme mimics containing the ATCUN site 9
Totale 9.882
Categoria #
all - tutte 48.499
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 48.499


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021682 0 0 0 0 0 93 92 115 46 178 76 82
2021/2022690 31 91 147 32 27 33 43 26 33 51 34 142
2022/2023522 57 61 12 60 73 53 49 45 55 3 39 15
2023/2024481 50 47 24 25 25 81 25 47 22 24 14 97
2024/20251.904 67 38 160 96 162 154 51 95 342 189 289 261
2025/20263.326 567 311 541 666 887 354 0 0 0 0 0 0
Totale 9.882