PACIFICO, Salvatore
 Distribuzione geografica
Continente #
NA - Nord America 3.531
EU - Europa 1.211
AS - Asia 910
SA - Sud America 109
AF - Africa 9
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 3
Totale 5.776
Nazione #
US - Stati Uniti d'America 3.515
SG - Singapore 447
IT - Italia 446
PL - Polonia 247
CN - Cina 246
DE - Germania 113
UA - Ucraina 99
BR - Brasile 93
TR - Turchia 90
GB - Regno Unito 70
ID - Indonesia 57
SE - Svezia 43
IE - Irlanda 42
FI - Finlandia 39
BE - Belgio 24
HK - Hong Kong 20
NL - Olanda 16
VN - Vietnam 16
CZ - Repubblica Ceca 14
CA - Canada 13
RU - Federazione Russa 13
AT - Austria 11
FR - Francia 8
ZA - Sudafrica 7
AR - Argentina 6
ES - Italia 5
IN - India 5
LT - Lituania 5
IR - Iran 4
BD - Bangladesh 3
CL - Cile 3
EU - Europa 3
PE - Perù 3
PK - Pakistan 3
AU - Australia 2
BG - Bulgaria 2
DK - Danimarca 2
JP - Giappone 2
KW - Kuwait 2
KZ - Kazakistan 2
PT - Portogallo 2
RO - Romania 2
SA - Arabia Saudita 2
UZ - Uzbekistan 2
AL - Albania 1
AZ - Azerbaigian 1
BO - Bolivia 1
BS - Bahamas 1
BY - Bielorussia 1
CH - Svizzera 1
CR - Costa Rica 1
DZ - Algeria 1
EC - Ecuador 1
GR - Grecia 1
IL - Israele 1
JO - Giordania 1
KG - Kirghizistan 1
KR - Corea 1
LU - Lussemburgo 1
MA - Marocco 1
MK - Macedonia 1
MX - Messico 1
MY - Malesia 1
NO - Norvegia 1
NP - Nepal 1
NZ - Nuova Zelanda 1
OM - Oman 1
SK - Slovacchia (Repubblica Slovacca) 1
TW - Taiwan 1
UY - Uruguay 1
VE - Venezuela 1
Totale 5.776
Città #
Fairfield 480
Woodbridge 374
Ashburn 260
Warsaw 247
Ann Arbor 241
Ferrara 227
Houston 218
Chandler 212
Santa Clara 204
Singapore 200
Seattle 188
Cambridge 177
Wilmington 154
Jacksonville 119
Menlo Park 98
Jakarta 57
New York 57
Beijing 56
Princeton 55
Shanghai 47
Izmir 45
Milan 45
Los Angeles 43
Nanjing 41
San Diego 28
Addison 24
Brussels 24
Bologna 21
Nanchang 20
Boardman 19
Hong Kong 19
Dearborn 18
Helsinki 18
St Louis 18
London 16
Dong Ket 15
Ferrara di Monte Baldo 13
Munich 13
Nuremberg 13
Redwood City 13
Falkenstein 12
Mountain View 11
Brno 10
Falls Church 10
Bremen 9
Norwalk 9
Rome 9
The Dalles 9
Belo Horizonte 8
Cagliari 8
Des Moines 8
Padova 8
Jinan 7
San Mateo 7
Shenyang 7
Changsha 6
Toronto 6
Washington 6
Buenos Aires 5
Hebei 5
Jiaxing 5
Ottawa 5
Vienna 5
Auburn Hills 4
Dublin 4
Frankfurt am Main 4
Grassano 4
Guangzhou 4
Modena 4
Ningbo 4
Olomouc 4
Bari 3
Bournemouth 3
Chicago 3
Hefei 3
Leawood 3
Lima 3
Orange 3
St Petersburg 3
São Paulo 3
Tappahannock 3
Tianjin 3
Waban 3
Ardabil 2
Assago 2
Aversa 2
Buffalo 2
Campo Grande 2
Clifton 2
Contagem 2
Council Bluffs 2
Florence 2
Fort Huachuca 2
Haikou 2
Hyderabad 2
Islington 2
Kailua 2
Kunming 2
Kuwait City 2
La Canada Flintridge 2
Totale 4.414
Nome #
Serum beta-secretase 1 (BACE1) activity as candidate biomarker for late-onset Alzheimer’s disease 239
Sintesi di glicopeptidi mediante le reazioni tiol-ene/ino e studio della reattività di Umpolung di α-dichetoni 211
A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism 186
Expeditious Synthesis and Biological Characterization of Enantio-Enriched (-)-Nutlin-3 177
Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones 173
Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction 156
Structure activity studies of nociceptin/orphanin FQ(1–13)-NH2 derivatives modified in position 5 149
Photoinduced addition of glycosyl thiols to alkynyl peptides: use of free-radical thiol-yne coupling for post-translational double-glycosylation of peptides 144
Modulation of the NOP receptor signaling affects resilience to acute stress 143
Structure-and conformation-Activity studies of nociceptin/orphanin FQ receptor dimeric ligands 142
Indole derivatives as multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones 137
One-pot, two-step desymmetrization of symmetrical benzils catalyzed by the methylsulfinyl (dimsyl) anion 136
Synthesis of S-glycosyl amino acids and S-glycopeptides via photoinduced click thiol-ene coupling 123
Neuropeptide S receptor ligands: a patent review (2005-2016) 122
Biased Agonism at Nociceptin/Orphanin FQ Receptors: A Structure Activity Study on N/OFQ(1-13)-NH2 120
Peptide welding technology – A simple strategy for generating innovative ligands for G protein coupled receptors 120
Activation of nociceptin/orphanin FQ receptors inhibits contextual fear memory reconsolidation 118
Discovery of novel fetal hemoglobin inducers for β-thalassemia by small chemical library screening 115
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 114
Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor 114
Intracellular quantitative detection of human thymidylate synthase engagement with an unconventional inhibitor using tetracysteine-diarsenical-probe technology 114
Synthesis and evaluation of antioxidant and antiproliferative activity of 2-arylbenzimidazoles 112
Synthesis and Biological Activity of Peptide α-Ketoamide Derivatives as Proteasome Inhibitors 111
null 110
Tetrabranched Hetero-Conjugated Peptides as Bifunctional Agonists of the NOP and Mu Opioid Receptors 110
null 108
Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth 106
Increased blood BACE1 activity as a potential common pathogenic factor of vascular dementia and late onset Alzheimer's disease 106
The Tat Protein of HIV-1 Prevents the Loss of HSV-Specific Memory Adaptive Responses and Favors the Control of Viral Reactivation 96
alpha-Diketones as acyl anion equivalents: a non-enzymatic thiamine-promoted route to aldehyde ketone coupling in PEG(400) as recyclable medium 95
null 94
Fluorometric detection of protein-ligand engagement: The case of phosphodiesterase5 94
null 92
alpha-Diketones as acyl anion equivalents: new enzymatic and non-enzymatic thiamine-promoted routes to aldehyde-ketone coupling 86
Thiazolium-catalyzed intermolecular Stetter reaction of linear and cyclic alkyl α-diketones 84
null 79
Impaired Priming of SARS-CoV-2-Specific Naive CD8+ T Cells in Older Subjects 76
Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells 69
Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity 69
Novel Aryl Sulfonamide Derivatives as NLRP3 Inflammasome Inhibitors for the Potential Treatment of Cancer 68
Reactivity of dialkyl and diaryl alpha-diketones with N-heterocyclic carbenes 64
Effects of non-peptide nociceptin/orphanin FQ receptor ligands on methylphenidate-induced hyperactivity in mice: Implications for bipolar disorders 62
Novel Mixed NOP/Opioid Receptor Peptide Agonists 58
Ageing Curtails the Diversity and Functionality of Nascent CD8+ T Cell Responses against SARS-CoV-2 57
null 57
Cyclic peptides acting as allosteric inhibitors of human thymidylate synthase and cancer cell growth 55
Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting 55
Functional Selectivity Does Not Predict Antinociceptive/Locomotor Impairing Potencies of NOP Receptor Agonists 53
Use of a Novel Peptide Welding Technology Platform for the Development of B- and T-Cell Epitope-Based Vaccines 52
Probing the Effect of Sildenafil on Progesterone and Testosterone Production by an Intracellular FRET/BRET Combined Approach 50
Serum beta-secretase 1 (BACE1) activity increases in patients with mild cognitive impairment 48
Identification of small-molecule urea derivatives as PTPC modulators targeting the c subunit of F1/Fo-ATP synthase 47
Thermodynamic Stability and Speciation of Ga(III) and Zr(IV) Complexes with High-Denticity Hydroxamate Chelators 47
In vitro and in vivo pharmacological characterization of a neuropeptide S tetrabranched derivative 44
Age differentially impacts adaptive immune responses induced by adenoviral versus mRNA vaccines against COVID-19 41
A Peptidic Thymidylate-Synthase Inhibitor Loaded on Pegylated Liposomes Enhances the Antitumour Effect of Chemotherapy Drugs in Human Ovarian Cancer Cells 40
Dimethyl Sulfoxide and N,N-dimethylformamide as Umpolung Pre-catalysts in Cross Benzoin Reactions of alpha-Diketones with Aldehydes 38
Age, Sex, Hypertension and HDL-C Alter Serum BACE1 Activity in Cognitively Normal Subjects: Implications for Alzheimer's Disease 37
Bifunctional octadentate pseudopeptides as Zirconium-89 chelators for immuno-PET applications 37
Thiazolium-functionalized polystyrene monolithic microreactors for continuous-flow umpolung catalysis 31
Methylsulfinyl (Dimsyl) Anion as Umpolung Catalyst for the Chemoselective Cross Benzoin Reaction of α-Diketones with Aldehydes 28
Unexpected reactivity of diaryl α-diketones with thiazolium carbenes: discovery of a novel multicomponent reaction for the facile synthesis of 1,4-thiazin-3-ones 27
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth 27
Thiazolium-Functionalized Polystyrene Monolithic Microreactors for Continuous-Flow Umpolung Catalysis 26
Phosphodiesterase (PDE) 5 inhibitors sildenafil, tadalafil and vardenafil impact cAMP-specific PDE8 isoforms-linked second messengers and steroid production in a mouse Leydig tumor cell line 23
Synthesis of Chiral Ionic Liquids from Natural Monosaccharides 14
Probing non-peptide agonists binding at the human nociceptin/orphanin FQ receptor: a molecular modelling study 8
COMPOSTI TETRAIDROISOCHINOLINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 5
Compounds as nlrp3 inflammasome inhibitors and their use as medicaments 5
COMPOSTI SOLFONAMMIDICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 5
COMPOSTI PIRROLIDINICI E PIPERIDINICI COME INIBITORI DELL’INFLAMMASOMA NLRP3 E LORO USO COME MEDICAMENTI 3
Totale 5.962
Categoria #
all - tutte 35.031
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 35.031


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020157 0 0 0 0 0 0 0 0 0 72 50 35
2020/20211.027 47 104 47 74 73 93 92 115 46 178 76 82
2021/2022690 31 91 147 32 27 33 43 26 33 51 34 142
2022/2023522 57 61 12 60 73 53 49 45 55 3 39 15
2023/2024481 50 47 24 25 25 81 25 47 22 24 14 97
2024/20251.310 67 38 160 96 162 154 51 95 342 145 0 0
Totale 5.962