A diastereoselective synthesis of the title compound as a single E diastereomer has been efficiently accomplished by assembling the featured pyrano-indole scaffold of the spiro[cyclohexanedihydropyrano[ 3,4-b]-indole]-amine framework through an oxa-Pictet-Spengler reaction, promoted by a cheap and green Zeolite catalyst. Basic pharmacological experiments demonstrate that Cebranopadol acts as a mixed nociception/orphanin FQ (NOP) and mu (MOP) opioid receptor agonist useful for treatment of chronic pain.
Titolo: | A diastereoselective synthesis of Cebranopadol, a novel analgesic showing NOP/mu mixed agonism |
Autori: | FANTINATI, Anna (Primo) |
Data di pubblicazione: | 2017 |
Rivista: | |
Handle: | http://hdl.handle.net/11392/2371408 |
Appare nelle tipologie: | 03.1 Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
Fantinati_et_al-2017-Scientific_Reports.pdf | Fantinati Scientific Report 2017 | Full text (versione editoriale) | ![]() | Open Access Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.