Distribuzione geografica
Continente #
NA - Nord America 6967
EU - Europa 1875
AS - Asia 1325
SA - Sud America 5
OC - Oceania 3
AF - Africa 2
Continente sconosciuto - Info sul continente non disponibili 2
Totale 10179
Nazione #
US - Stati Uniti d'America 6952
CN - Cina 800
UA - Ucraina 662
TR - Turchia 439
DE - Germania 350
GB - Regno Unito 238
SE - Svezia 215
FI - Finlandia 139
IT - Italia 124
VN - Vietnam 62
FR - Francia 37
PL - Polonia 37
BE - Belgio 31
RU - Federazione Russa 21
CA - Canada 13
IN - India 11
AT - Austria 9
BR - Brasile 3
IR - Iran 3
A2 - ???statistics.table.value.countryCode.A2??? 2
CH - Svizzera 2
ES - Italia 2
ID - Indonesia 2
IQ - Iraq 2
NL - Olanda 2
NZ - Nuova Zelanda 2
AU - Australia 1
BD - Bangladesh 1
BG - Bulgaria 1
CL - Cile 1
DK - Danimarca 1
EC - Ecuador 1
EG - Egitto 1
KR - Corea 1
LB - Libano 1
MD - Moldavia 1
ME - Montenegro 1
MX - Messico 1
PA - Panama 1
PH - Filippine 1
PT - Portogallo 1
RO - Romania 1
SD - Sudan 1
TW - Taiwan 1
UZ - Uzbekistan 1
Totale 10179
Città #
Woodbridge 977
Fairfield 914
Houston 770
Jacksonville 711
Chandler 593
Ann Arbor 488
Wilmington 356
Seattle 350
Ashburn 348
Cambridge 264
Nanjing 243
Izmir 220
Princeton 158
Beijing 105
Boardman 96
San Diego 89
Shenyang 77
Nanchang 65
Dong Ket 61
Jiaxing 41
San Mateo 37
Hebei 34
Milan 34
Tianjin 34
Kunming 32
Brussels 31
Ferrara 31
Warsaw 31
Changsha 30
Dearborn 30
Jinan 27
Zhengzhou 27
Falls Church 26
Philadelphia 23
Norwalk 22
Ningbo 18
Addison 17
Bremen 14
Mountain View 14
Munich 13
Taizhou 13
Verona 13
Montréal 12
Redwood City 12
Indiana 11
Augusta 9
Helsinki 9
Mcallen 9
Orange 9
Vienna 9
Auburn Hills 8
Des Moines 8
Guangzhou 8
Redmond 8
Leawood 6
Los Angeles 6
Shanghai 6
Düsseldorf 5
Haikou 5
Hangzhou 5
London 5
Lanzhou 4
San Francisco 4
Yellow Springs 4
Changchun 3
Ferrara di Monte Baldo 3
Fuzhou 3
Hefei 3
Monmouth Junction 3
New York 3
Ardabil 2
Baghdad 2
Chicago 2
Cosenza 2
Misterbianco 2
Mumbai 2
Padova 2
Peterborough 2
Polska 2
Rome 2
Saint Petersburg 2
Santa Clara 2
Stockholm 2
Taiyuan 2
Walnut 2
Xian 2
Andover 1
Bangalore 1
Baotou 1
Barlad 1
Berlin 1
Billerica 1
Bologna 1
Camerino 1
Chaoyang 1
Charlottetown 1
Chisinau 1
Comiso 1
Curitiba 1
Delhi 1
Totale 7703
Nome #
1,2,3-triazolo[5,4-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives: A new class of A(2A) adenosine receptor antagonists 214
1-methyl-3-nitro-5-methoxycarbonyl pyrazole 153
5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors 143
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers. 129
Synthesis and antitumor activity of novel distamycin derivatives 118
null 118
1H-pyrazolo[2,3-d][1,2,4]triazine-3,7-diones as a new class of human leukocyte elastase inhibitors 117
The influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl moiety on the adenosine receptors affinity profile of pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c] pyrimidine derivatives 114
Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists 113
[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1 109
New potent and selective human adenosine A3 receptor antagonists. 109
DNA minor groove alkylating agents structurally related to distamycin A 108
Synthesis and calcium antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(nitrogenous heteroaryl)-3,5-pyridine dicarboxylates. 108
A new synthetic approach to indazole synthesis 105
null 104
New 9-methyl-8-(4-hydroxyphenyl)adenine derivatives as A1 adenosine receptor antagonists 104
8-(2-Furyl)adenine derivatives as A₂A adenosine receptor ligands 103
6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors 102
Synthesis and antitumor activity of a new class of pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone analogs of pyrrolo[1,4]benzodiazepines (PBDs) 102
Oligonucleotides and oligonucleotide conjugates: A new approach for cancer treatment 101
Carbon nanotube substrates boost neuronal electrical signaling 101
Design, synthesis and biological activity of a pyrrolo[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid 100
DNA minor-groove binders: results and design of new antitumor agents 99
Structure-activity relationship of novel tallimustine derivatives: Synthesis and antitumor activity 97
Facile and versatile route to the synthesis of fused 2-pyridones: Useful intermediates for polycyclic sytems 96
Selective binding to human genomic sequences of two synthetic analogues structurally related to U-71184 and adozelesin 96
Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach 96
Synthesis and preliminary biological evaluation of [H-3]-MRE 3008-F20: the first high affinity radioligand antagonist for the human A(3) adenosine receptors 95
An efficient procedure for the synthesis of 5H-6-substituted-pyrazolo[1,5-d]-1,2,4-triazine-4,7-diones 95
Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors 95
Resolution of a CPzI precursor, synthesis and biological evaluation of (+) and (-)-N-Boc-CPzI: A further validation of the relationship between chemical solvolytic stability and cytotoxicity 95
A2A-adenosine receptor reserve for coronary vasodilation 94
Nitrile oxide [3 + 2] cycloaddition: application to the synthesis of 6-substituted 3(2H)-pyridazinones and 6-substituted 4,5-dihydro-4-hydroxy-3(2H)-pyridazinones 93
Ethyl (R,S)-5-acetyl-4,5-dihydro-3-isoxazoleacetate 93
Synthesis and Antitumor Activity of a New Class of Pyrazolo[4,3-e]pyrrolo[1,2-a][1,4]diazepinone Analogs of Pyrrolo[1,4][2,1-c]benzodiazepines 93
Ethyl-(R,S)-5-acetyl-4,5-dihydro-3-isoxazole acetate 92
null 90
Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: a complete structure-activity profile. 89
Solid lipid microparticles for the stability enhancement of a dopamine prodrug 89
The Significance of 2-Furyl Ring Substitution with a 2-(para-substituted) Aryl Group in a New Series of Pyrazolo-triazolo-pyrimidines as Potent and Highly Selective hA3 Adenosine Receptors Antagonists: New Insights into Structure-Affinity Relationship and Receptor-Antagonist Recognition 89
Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c] [1,4]benzodiazepines 89
New potent and selective human adenosine A3 receptor antagonists 89
Chemical synthesis of [13C]daidzein. 88
null 87
Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines as Human A(2A) Adenosine Receptor Antagonists with Improved Water Solubility 87
CC-1065 and the duocarmycins: recent developments 86
Linear and nonlinear 3D-QSAR approaches in tandem with ligand-based homology modeling as a computational strategy to depict the pyrazolo-triazolo-pyrimidine antagonists binding site of the human adenosine A2A receptor 86
Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxo-6-methyl-8-(substituted) 1,2,3,4-tetrahydro [1,2,4]-triazolo [3,4-f]-purines as potential adenosine receptor antagonists 84
Synthesis of pyridazine derivatives through the unexpected intermediate 5-amino-4-cyano-2,3-dihydro-furan-2,3-disulfonic acid disodium salt 84
Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors 84
Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling 83
Exploring Potency and Selectivity Receptor Antagonist Profiles Using a Multilabel Classification Approach: The Human Adenosine Receptors as a Key Study 83
Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes. 83
Cosmetic preservation and structure-activity relationships of 4-diazo-pyrazole-5-carboxamides 82
Synthesis and properties of substituted CBI analogs of CC-1065 and the duocarmycins incorporating the 7-methoxy-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (MCBI) alkylation subunit: Magnitude of electronic effects on the functional reactivity 82
Carbon Nanotubes Carrying Cell-Adhesion Peptides do not Interfere with Neuronal Functionality 80
Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process 78
Antiproliferative effects of novel synthetic nucleobase analogues on U937 Histiocytic lymphoma cell line 78
null 77
Binding affinity of adenosine receptor agonists and antagonists at human cloned A3 adenosine receptors 76
5-heteroarylcarbamoylamino-pyrazolo-triazolo pyrimidines as hA3 adenosine receptor antagonists. 75
Recent developments in the field of adenosine receptor ligands 75
Substituted 6-amino-thiouracils as new P2Y(12) receptor antagonists 74
A(3) adenosine receptor ligands: History and perspectives 74
7-substituted-5-amino-2-(furyl)-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonists: importance of modifications at the side chain on the activity and solubility. 74
[3H]-MRE 3008-F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A3 adenosine receptors. 72
7-substituted 5-amino-2-(2-furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines as A(2A) adenosine receptor antagonists: A study on the importance of modifications at the side chain on the activity and solubility 72
Pyrazolo [4,3-E]1,2,4-triazolo[1,5-c]pyrimidine derivates a new class of potent and selective human A3 adenosine receptor antagonists. 71
Synthesis and Biological Activity of a New Series of N6-Arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-Carboxamido Derivatives of Adenosine-5'-N-ethyluronamide as A1 and A3 Adenosine Receptor Agonists 69
Synthesis and cardiodepressant activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pentatomic-heteroaryl)-3,5-pyridinedicarboxylates. 2 68
A(1) and A(3) adenosine receptor agonists: an overview 68
1H-pyrazolo[4,3-d]pyrimidine-7(6H)-one and 5H-pyrazolo[4,3-d] 1,2,3-triazin-4(3H)-one derivatives. Synthesis and in vitro biological activity at adenosine A1 and A2a receptors 68
A2Aadenosine receptor antagonists as therapeutic candidates: Are they still an interesting challenge? 67
7-sobstituted-5-amino-2-(furyl)-pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as A2A adenosine receptor antagonist: importance of modifications at the side chain on the activity and solubility. 66
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]-pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists 65
Novel N-6-(substituted-phenylcarbamoyl)adenosine-5'-uronamides as potent agonists for A(3) adenosine receptors 65
Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives: Potent and selective A(2A) adenosine antagonists 65
[3H]MRE3008-F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A3 adenosine receptors. 65
Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A(3) adenosine receptor antagonists 65
[H-3]MRE 3008F20: A novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors 65
Synthesis and molecular investigation of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivates as human A3 adenosine receptor antagonists. 63
Heterocyclic analogs of DNA minor groove alkylating agents 62
Pyridazine nucleus: a pharmacophoric moiety for bio-active compounds 61
Synthesis, binding and thermodynamic studies of new highly selective A2A adenosine receptor antagonists 61
Synthesis, antibacterial activity and structure-activity relationships of N-substituted 4-diazopyrazole-5-carboxamides. 2 60
Synthesis, biological and modeling studies of new water soluble hA3 adenosine receptor antagonists. 60
Rationale design of new human adenosione A3 receptor antagonists through a CoMFA model. 60
Synthesis, cytotoxicity and antitumor activity of some new simplified pyrazole analogs of the antitumor agent CC-1065. Effect of an hydrophobic group on antitumor activity 58
Synthesis and molecular investigation of new pyrazolo[4,3-e]1,2,4,-triazolo[1,5-c]pyrimidine derivates as human A3 adenosine receptor antagonists. 58
Comparative molecular field analysis (CoMFA) of a series of selective adenosine receptor A(2A) antagonists 57
Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist 57
Binding affinity of adenosine receptor agonists and antagonists at human A3 adenosine receptors 57
Synthesis, biological properties and molecular modelling investigation of the first potent, selective and water soluble human A3 adenosine receptor antagonist. 57
Conjugation of Dopamine and an A2A Adenosine Receptor Antagonist: a possible approach for the treatment of Parkinson’s Disease. 56
Synthesis, antiviral and antiproliferative activity of a new class of 5-(alkyl or arylthio)-6-vinyl uracils 56
Second generation of A2A adenosine receptor antagonist: synthesis and biological evaluation 56
Triazolo-triazine as new adenosine receptor antagonists. 55
Synthesis and preliminary biological evaluation of [3H]-MRE 3008F20: the first high affinity radioligand antagonist for the human A3 adenosine receptors 54
Synthesis of the tritium labeled SCH 58261, a new non-xanthine A(2A) adenosine receptor antagonist 54
Totale 8480
Categoria #
all - tutte 19290
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 93
Totale 19383

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2017/2018114 0000 00 00 1086126
2018/20191657 27385 1318 2247 138254308598
2019/20202280 4577258329 138260 190234 1652657537
2020/20211641 144145112183 50167 32199 36188232153
2021/20221361 3913878135 8551 4283 3898153421
2022/20231215 1586326171 220223 41142 171000
Totale 10294