A series of 4-​diazopyrazole-​5-​carboxamides were synthesized and their antibacterial activity against a no. of Gram-​neg. and Gram-​pos. strains was tested. Some of the compds. were quite active and the whole set was allowed to further study the SAR of the class. Substituents in position 5 affect Gram-​neg. and Gram-​pos. activities via bulk and electronic properties resp.; position 3 mostly affects the Gram-​neg. activity, while the presence of the charged diazo group in position 4 is crucial for both antibacterial activities.

Synthesis, antibacterial activity and structure-activity relationships of N-substituted 4-diazopyrazole-5-carboxamides. 2

BARALDI, Pier Giovanni;CACCIARI, Barbara;MANFREDINI, Stefano;SIMONI, Daniele
1991

Abstract

A series of 4-​diazopyrazole-​5-​carboxamides were synthesized and their antibacterial activity against a no. of Gram-​neg. and Gram-​pos. strains was tested. Some of the compds. were quite active and the whole set was allowed to further study the SAR of the class. Substituents in position 5 affect Gram-​neg. and Gram-​pos. activities via bulk and electronic properties resp.; position 3 mostly affects the Gram-​neg. activity, while the presence of the charged diazo group in position 4 is crucial for both antibacterial activities.
1991
Baraldi, Pier Giovanni; Cacciari, Barbara; Leoni, Alberto; Recanatini, Maurizio; Roberti, Marinella; Rossi, Maddalena; Manfredini, Stefano; Periotto, Vittorio; Simoni, Daniele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460402
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