Synthesis, antibacterial activity and structure-activity relationships of N-substituted 4-diazopyrazole-5-carboxamides. 2

A series of 4-​diazopyrazole-​5-​carboxamides were synthesized and their antibacterial activity against a no. of Gram-​neg. and Gram-​pos. strains was tested. Some of the compds. were quite active and the whole set was allowed to further study the SAR of the class. Substituents in position 5 affect Gram-​neg. and Gram-​pos. activities via bulk and electronic properties resp.; position 3 mostly affects the Gram-​neg. activity, while the presence of the charged diazo group in position 4 is crucial for both antibacterial activities.