[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1

We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.



Titolo: [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1
Autori: 
BARALDI, Pier Giovanni
CACCIARI, Barbara
ROMAGNOLI, Romeo
BIANCHI, Nicoletta
FERIOTTO, Giordana
MISCHIATI, Carlo
GAMBARI, Roberto
mostra contributor esterni 
Data di pubblicazione: 2000
Rivista: 
NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS  
Abstract: We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.
Handle: http://hdl.handle.net/11392/516878
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