We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.

[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid inhibits DNA binding to transcription factor Sp1

BARALDI, Pier Giovanni;CACCIARI, Barbara;ROMAGNOLI, Romeo;BIANCHI, Nicoletta;FERIOTTO, Giordana;MISCHIATI, Carlo;GAMBARI, Roberto
2000

Abstract

We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.
Baraldi, Pier Giovanni; Cacciari, Barbara; Guiotto, A; Romagnoli, Romeo; Spalluto, G; Leoni, A; Bianchi, Nicoletta; Feriotto, Giordana; Rutigliano, C; Mischiati, Carlo; Gambari, Roberto
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/516878
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