We report the synthesis of a new hybrid 13 which is a combination of the naturally occurring antitumor agent distamycin A 1 and the pyrrolo[2,1-c][1,4]benzodiazepine 11, related to the naturally occurring anthramycin 2. The antitumor activity of the hybrid 13 was tested in vitro and compared to the natural product distamycin 1 and the PBD 11.

Design, synthesis and biological activity of a pyrrolo[2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid

BARALDI, Pier Giovanni;CACCIARI, Barbara;ROMAGNOLI, Romeo;BIANCHI, Nicoletta;GAMBARI, Roberto
1998

Abstract

We report the synthesis of a new hybrid 13 which is a combination of the naturally occurring antitumor agent distamycin A 1 and the pyrrolo[2,1-c][1,4]benzodiazepine 11, related to the naturally occurring anthramycin 2. The antitumor activity of the hybrid 13 was tested in vitro and compared to the natural product distamycin 1 and the PBD 11.
1998
Baraldi, Pier Giovanni; Cacciari, Barbara; Guiotto, A; Leoni, A; Romagnoli, Romeo; Spalluto, G; Mongelli, N; Howard, Pw; Thurston, De; Bianchi, Nicoletta; Gambari, Roberto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/516945
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