SECCHIERO, Paola
 Distribuzione geografica
Continente #
NA - Nord America 28.243
AS - Asia 13.510
EU - Europa 7.734
SA - Sud America 2.212
Continente sconosciuto - Info sul continente non disponibili 582
AF - Africa 315
OC - Oceania 30
AN - Antartide 1
Totale 52.627
Nazione #
US - Stati Uniti d'America 27.684
SG - Singapore 5.094
CN - Cina 3.301
IT - Italia 2.026
BR - Brasile 1.747
VN - Vietnam 1.487
DE - Germania 1.127
HK - Hong Kong 1.092
UA - Ucraina 1.068
GB - Regno Unito 773
TR - Turchia 741
PL - Polonia 676
FI - Finlandia 473
FR - Francia 413
BD - Bangladesh 412
RU - Federazione Russa 346
JP - Giappone 298
CA - Canada 285
SE - Svezia 284
IN - India 262
ID - Indonesia 228
MX - Messico 184
AR - Argentina 181
ZA - Sudafrica 129
NL - Olanda 118
IQ - Iraq 99
ES - Italia 97
PK - Pakistan 73
EC - Ecuador 64
BE - Belgio 57
CO - Colombia 57
VE - Venezuela 55
UZ - Uzbekistan 52
SA - Arabia Saudita 51
LT - Lituania 41
MY - Malesia 40
CZ - Repubblica Ceca 39
MA - Marocco 37
CL - Cile 33
AT - Austria 32
EG - Egitto 32
PH - Filippine 27
AU - Australia 26
TN - Tunisia 26
AE - Emirati Arabi Uniti 24
PY - Paraguay 24
DZ - Algeria 22
JO - Giordania 20
KE - Kenya 20
KR - Corea 20
IR - Iran 19
JM - Giamaica 19
TW - Taiwan 19
UY - Uruguay 19
BO - Bolivia 17
CH - Svizzera 17
RO - Romania 17
AZ - Azerbaigian 16
CR - Costa Rica 15
EE - Estonia 15
IL - Israele 15
IE - Irlanda 14
KG - Kirghizistan 14
NP - Nepal 14
OM - Oman 14
LK - Sri Lanka 13
PE - Perù 12
PT - Portogallo 12
DO - Repubblica Dominicana 11
TH - Thailandia 11
BG - Bulgaria 10
GR - Grecia 10
HN - Honduras 10
PS - Palestinian Territory 10
RS - Serbia 10
ET - Etiopia 9
KZ - Kazakistan 8
SN - Senegal 8
AL - Albania 7
CI - Costa d'Avorio 7
LB - Libano 7
SK - Slovacchia (Repubblica Slovacca) 7
TT - Trinidad e Tobago 7
DK - Danimarca 6
GE - Georgia 6
GT - Guatemala 6
MD - Moldavia 6
NI - Nicaragua 6
HR - Croazia 5
CY - Cipro 4
HU - Ungheria 4
LV - Lettonia 4
LY - Libia 4
PA - Panama 4
SV - El Salvador 4
TG - Togo 4
BA - Bosnia-Erzegovina 3
BN - Brunei Darussalam 3
KW - Kuwait 3
MK - Macedonia 3
Totale 51.985
Città #
Ashburn 3.367
Singapore 3.125
Fairfield 2.805
Woodbridge 2.510
San Jose 1.681
Houston 1.655
Jacksonville 1.170
Seattle 1.142
Chandler 1.100
Hong Kong 1.073
Ann Arbor 1.062
Santa Clara 1.046
Wilmington 992
Beijing 988
Cambridge 956
Warsaw 660
Ferrara 622
Dallas 546
Los Angeles 504
Ho Chi Minh City 483
Council Bluffs 423
New York 414
Izmir 371
Hanoi 342
Nanjing 339
Princeton 280
Tokyo 277
Lauterbourg 254
Munich 236
Boardman 233
Milan 232
San Diego 215
São Paulo 179
Helsinki 166
Jakarta 166
Shanghai 152
Buffalo 131
Orem 129
London 114
Mexico City 110
Bologna 108
Nanchang 108
Chicago 107
Shenyang 105
Dearborn 98
Tianjin 92
Denver 90
Montreal 89
Brooklyn 87
Chennai 79
The Dalles 79
Hefei 76
Toronto 74
Da Nang 73
Turku 73
Frankfurt am Main 72
Atlanta 70
Falls Church 70
Johannesburg 70
Rome 66
Changsha 65
San Francisco 64
Hebei 59
Moscow 57
Dong Ket 56
Poplar 56
Brussels 55
Jiaxing 55
Mountain View 54
Haiphong 53
Columbus 52
Phoenix 52
Stockholm 52
Bremen 47
Boston 46
Manchester 46
Zhengzhou 43
Tashkent 42
Rio de Janeiro 41
San Mateo 41
Baghdad 39
Kunming 39
Norwalk 39
Jinan 38
Redwood City 37
Auburn Hills 35
Mumbai 35
Guangzhou 34
Verona 34
Hải Dương 33
Tappahannock 32
Washington 31
Ankara 30
Matera 30
Istanbul 29
Nuremberg 29
Philadelphia 29
Porto Alegre 29
Brasília 28
Amsterdam 27
Totale 35.629
Nome #
Gene-gene interactions among coding genes of iron-homeostasis proteins and APOE-alleles in Cognitive Impairment Diseases 490
Cell cycle block by p53 acrivation reduces SARS-COV-2 release in infected alveolar basal epithelial A549-hACE2 cells 347
Design, synthesis and biological characterization of novel mitochondria targeted dichloroacetate-loaded compounds with antileukemic activity 336
Anti-leukemic activity of microRNA-26a in a chronic lymphocytic leukemia mouse model 302
Serum From Advanced Heart Failure Patients Promotes Angiogenic Sprouting and Affects the Notch Pathway in Human Endothelial Cells 280
Cell cycle block by p53 activation reduces SARS-CoV-2 release in infected alveolar basal epithelial A549-hACE2 cells 279
The anti-leukemic activity of sodium dichloroacetate in p53(mutated/null) cells is mediated by a p53-independent ILF3/p21 pathway 276
Intranasal Administration of Recombinant TRAIL Down-Regulates CXCL-1/KC in an Ovalbumin-Induced Airway Inflammation Murine Model 276
Expeditious Synthesis and Biological Characterization of Enantio-Enriched (-)-Nutlin-3 274
Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3 272
MDM2/X inhibitors under clinical evaluation: Perspectives for the management of hematological malignancies and pediatric cancer 271
Anticancer Activity of Aqueous Extracts from Asparagus officinalis L. Byproduct on Breast Cancer Cells 270
Ibrutinib synergizes with MDM-2 inhibitors in promoting cytotoxicity in B chronic lymphocytic leukemia 268
Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism 263
COVID-19 and individual genetic susceptibility/receptivity: Role of ACE1/ACE2 genes, immunity, inflammation and coagulation. might the double x-chromosome in females be protective against SARS-COV-2 compared to the single x-chromosome in males? 263
A set of NF-κB-regulated microRNAs induces acquired TRAIL resistance in Lung cancer 256
Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells 252
Actively targeted nanocarriers for drug delivery to cancer cells 252
Antiangiogenic activity of the MDM2 antagonist nutlin-3 250
Conjunctival sac fluid contains elevated levels of soluble TRAIL: implications for the anti-tumoral surveillance of the anterior surface of the eye 250
Association between thyroid hormones and TRAIL 250
HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts 250
Association of tumor necrosis factor-related apoptosis-inducing ligand with total and cardiovascular mortality in older adults 246
CCR4+ skin-tropic phenotype as a feature of central memory CD8+ T cells in healthy subjects and psoriasis patients 245
Characterization of human herpesvirus 6 strains isolated from patients with exanthem subitum with or without cutaneous rash 244
Association of serum tumor necrosis factor-related apoptosis inducing ligand with body fat distribution as assessed by dual X-rays absorptiometry 243
Coagulation Factor XII Levels and Intrinsic Thrombin Generation in Multiple Sclerosis 240
Serum Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Levels in Older Subjects with Dementia and Mild Cognitive Impairment 237
Multiple dye-doped NIR-emitting silica nanoparticles for both flow cytometry and in vivo imaging 235
TNF-related apoptosis inducing ligand in ocular cancers and ocular diabetic complications 230
Upregulation of the alternative splicing factor NOVA2 in colorectal cancer vasculature 230
Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1 230
Elevated levels of TRAIL in systemic lupus erythematosus are associated to the presence of anti-SSA/SSB antibodies 229
Human bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-hodgkin's lymphoma xenografts 229
GM-CSF Exhibits Anti-Inflammatory Activity on Endothelial Cells Derived from Chronic Venous Disease Patients 229
Differential gene expression induction by TRAIL in B chronic lymphocytic leukemia (B-CLL) cells showing high versus low levels of Zap-70 228
TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress 228
The MDM-2 antagonist nutlin-3 promotes the maturation of acute myeloid leukemic blasts 227
Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes 227
The p53 transcriptional pathway is preserved in ATMmutated and NOTCH1mutated chronic lymphocytic leukemias 227
Characterization Methods for Nanoparticle–Skin Interactions: An Overview 226
Circulating levels of frizzled-related protein (FRZB) are increased in patients with early rheumatoid arthritis and decrease in response to disease-modifying antirheumatic drugs. 226
Anti-leukemic activity of Dasatinib in both p53 wild-type and p53 mutated B malignant cells 226
The circulating levels of TRAIL are extremely low after delivery but rapidly recover in both mothers and newborns 226
Association of Soluble Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) with Central Adiposity and Low-Density Lipoprotein Cholesterol 224
Clinical perspectives of TRAIL: Insights into central nervous system disorders 222
TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells 221
The effectiveness of Robot-Assisted Gait Training versus conventional therapy on mobility in severely disabled progressIve MultiplE sclerosis patients (RAGTIME): Study protocol for a randomized controlled trial 220
Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress 220
Human Herpesvirus 7 infection induces profound cell cycle perturbations coupled to disregulation of cdc2 and cyclin B and polyploidization of CD4+ T Cells 217
Kinetic Profiles of Inflammatory Mediators in the Conjunctival Sac Fluid of Patients upon Photorefractive Keratectomy 217
Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets 217
The 85-kilodalton phosphoprotein (pp85) of human herpesvirus 7 is encoded by open reading frame U14 and localizes to a tegument substructure in virion particles 216
TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release 215
In Vitro Characterization of Circulating Endothelial Progenitor Cells Isolated from Patients with Acute Coronary Syndrome 215
Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL) 214
Applications of nanoparticles in cancer medicine and beyond: optical and multimodal in vivo imaging, tissue targeting and drug delivery 214
Nanoparticles Loaded with Nutlin-3 Display Cytotoxicity Towards p53(wild-type) JVM-2 But Not Towards p53(mutated) BJAB Leukemic Cells 213
Is there any role for tumour necrosis factor related apoptosis inducing ligand–osteoprotegerin (TRAIL–OPG) interaction in rheumatoid arthritis? 212
HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells 212
Circulating TRAIL shows a significant post-partum decline associated to stressful conditions 212
In vivo anti-lymphoma activity of an agonistic human recombinant anti-TRAIL-R2 minibody. 211
Redox signaling and oxidative stress: Cross talk with TNF-related apoptosis inducing ligand activity 211
Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity 209
Hydrogen sulfide down-regulates the expression and release of osteoprotegerin (OPG) by vascular endothelial cells 209
MDM2 antagonist Nutlin-3 suppresses the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway 208
The Sorafenib plus Nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of the FLT3 and p53 status 208
Effects of hypoxia and bed rest on markers of cardiometabolic risk: Compensatory changes in circulating trail and glutathione redox capacity 205
Eosinophils and purinergic signaling in health and disease 205
Involvement of TRAIL/TRAIL-receptors in human intestinal cell differentiation 204
The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40. 204
MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC 204
HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway 203
Combined treatment of CpG-oligodeoxynucleotide with Nutlin-3 induces strong immune stimulation coupled to cytotoxicity in B-chronic lymphocytic leukemic (B-CLL) cells 202
Metabolic Syndrome and Psoriasis: Pivotal Roles of Chronic Inflammation and Gut Microbiota 201
Anti-Inflammatory and Cortical Responses after Transcranial Direct Current Stimulation in Disorders of Consciousness: An Exploratory Study 201
A novel endovenous scaffold for the treatment of chronic venous obstruction in a porcine model: Histological and ultrastructural assessment 200
Plasma levels of soluble NCAM in multiple sclerosis 200
Proper design of silica nanoparticles combines high brightness, lack of cytotoxicity and efficient cell endocytosis 199
SARS-CoV-2 nucleocapsid-protein and ultrastructural modifications in small bowel of a four week negative COVID-19 patient 199
Relationship between low levels of circulating TRAIL and atheromatosis progression in patients with chronic kidney disease 198
Release of a specific set of proinflammatory adipokines by differentiating 3T3-L1 cells 196
Engagement of CD28 modulates CXC chemokine receptor 4 surface expression in both resting and CD3-stimulated CD4+ T cells 196
Multimodal near-infrared-emitting PluS Silica nanoparticles with fluorescent, photoacoustic, and photothermal capabilities 196
Molecular targets for selective killing of TRAIL-resistant leukemic cells. 195
Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts 194
MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3. 193
Association of human herpes virus 6 (HHV-6) with multiple sclerosis: Increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA 193
Chemoresistive Nanostructured Sensors for Tumor Pre-Screening 191
In-vitro anticancer activity of Asparagus officinalis extracts on breast carcinoma 190
Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells 190
Endothelial PDGF-BB produced ex vivo correlates with relevant hemodynamic parameters in patients affected by chronic venous disease 189
circRNAs as Epigenetic Regulators of Integrity in Blood–Brain Barrier Architecture: Mechanisms and Therapeutic Strategies in Multiple Sclerosis 188
Osteoprotegerin induces morphological and functional alterations in mouse pancreatic islets. 188
Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells 187
Human Colostrum and Breast Milk Contain High Levels of TNF-Related Apoptosis-Inducing Ligand (TRAIL). 184
Circulating levels of TNF-related apoptosis inducing-ligand are decreased in patients with large adult-type granulosa cell tumors—implications for therapeutic potential 184
Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication 183
State of art and recent developments of anti-cancer strategies based on TRAIL 183
TRAIL inhibits osteoclastic differentiation by counteracting RANKL-dependent p27Kip1 accumulation in pre-osteoclast precursors 182
Totale 22.699
Categoria #
all - tutte 228.407
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 228.407


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.870 87 314 220 115 161 164 175 165 101 233 334 801
2022/20232.687 296 131 95 311 408 394 116 245 358 48 160 125
2023/20241.451 162 182 53 38 105 201 45 148 30 30 59 398
2024/20256.733 214 192 533 310 851 515 285 389 1.154 632 957 701
2025/202620.042 1.835 862 1.785 2.370 2.681 1.349 2.226 1.093 1.917 2.255 1.130 539
2026/2027517 517 0 0 0 0 0 0 0 0 0 0 0
Totale 52.627