TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1. h (time 1) and 2-3. days (time 2) after delivery in a group of healthy women (n= 17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3. pg/ml median; 41.2. ±. 15.9 mean. ±. SD) to time 2 (71.6. pg/ml median; 73.8. ±. 27.8 mean. ±. SD). Similarly, circulating TRAIL levels were extremely low in the plasma of newborns (n= 41) within the first 24. h after partum (time 1; 27.5. pg/ml, median; 31.5. ±. 15.8 means. ±. SD), showing a significant increase 2-3. days after partum (time 2; 68.4. pg/ml, median; 75.1. ±. 36.7 mean. ±. SD). It is also noteworthy that the highest levels of plasma TRAIL were observed in newborns with the following characteristics: (i) born at later gestational age, (ii) Apgar score >9, (iii) higher birth weight, (iv) born through vaginal partum. In conclusion, we have demonstrated for the first time that the levels of circulating TRAIL are markedly low in both mothers and children after delivery, rapidly rising thereafter. Moreover, the highest levels of TRAIL are observed in newborns with the best clinical parameters. © 2013 Elsevier Ltd.
The circulating levels of TRAIL are extremely low after delivery but rapidly recover in both mothers and newborns
ZAULI, Giorgio;AGNOLETTO, Chiara;SECCHIERO, Paola
2013
Abstract
TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1. h (time 1) and 2-3. days (time 2) after delivery in a group of healthy women (n= 17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3. pg/ml median; 41.2. ±. 15.9 mean. ±. SD) to time 2 (71.6. pg/ml median; 73.8. ±. 27.8 mean. ±. SD). Similarly, circulating TRAIL levels were extremely low in the plasma of newborns (n= 41) within the first 24. h after partum (time 1; 27.5. pg/ml, median; 31.5. ±. 15.8 means. ±. SD), showing a significant increase 2-3. days after partum (time 2; 68.4. pg/ml, median; 75.1. ±. 36.7 mean. ±. SD). It is also noteworthy that the highest levels of plasma TRAIL were observed in newborns with the following characteristics: (i) born at later gestational age, (ii) Apgar score >9, (iii) higher birth weight, (iv) born through vaginal partum. In conclusion, we have demonstrated for the first time that the levels of circulating TRAIL are markedly low in both mothers and children after delivery, rapidly rising thereafter. Moreover, the highest levels of TRAIL are observed in newborns with the best clinical parameters. © 2013 Elsevier Ltd.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
