| Nome |
# |
|
Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists, file e309ade4-04d5-3969-e053-3a05fe0a2c94
|
649
|
|
The A3 adenosine receptor: history and perspectives, file e309ade2-c090-3969-e053-3a05fe0a2c94
|
634
|
|
A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy, file e309ade2-c09e-3969-e053-3a05fe0a2c94
|
203
|
|
Medicinal chemistry, pharmacology, and potential therapeutic benefits of cannabinoid CB2receptor agonists, file e309ade3-e598-3969-e053-3a05fe0a2c94
|
177
|
|
History and perspectives of A2A adenosine receptor antagonists as potential therapeutic agents, file e309ade3-e533-3969-e053-3a05fe0a2c94
|
150
|
|
Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents, file e309ade3-9be9-3969-e053-3a05fe0a2c94
|
76
|
|
Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3’,4’,5’-Trimethoxyphenyl)-2-Aryl-1H-Imidazole, file e309ade0-d8e0-3969-e053-3a05fe0a2c94
|
66
|
|
Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents, file e309ade1-5591-3969-e053-3a05fe0a2c94
|
55
|
|
Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety, file e309ade3-b282-3969-e053-3a05fe0a2c94
|
53
|
|
Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells, file e309ade1-ce26-3969-e053-3a05fe0a2c94
|
51
|
|
Synthesis and Structure Activity Relationship Investigation of Triazolo[1,5-a]pyrimidines as CB2 Cannabinoid Receptor Inverse Agonists, file e309ade3-ff5f-3969-e053-3a05fe0a2c94
|
35
|
|
Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin, file e309ade3-956d-3969-e053-3a05fe0a2c94
|
33
|
|
Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds, file e309ade3-94ea-3969-e053-3a05fe0a2c94
|
29
|
|
Current status of A1 adenosine receptor allosteric enhancers, file e309ade3-dddf-3969-e053-3a05fe0a2c94
|
28
|
|
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor, file e309ade3-cfd0-3969-e053-3a05fe0a2c94
|
25
|
|
A 2a adenosine receptor: Structures, modeling, and medicinal chemistry, file e309ade5-6130-3969-e053-3a05fe0a2c94
|
21
|
|
Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study, file e309ade3-ffd2-3969-e053-3a05fe0a2c94
|
20
|
|
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors, file e309ade4-e60b-3969-e053-3a05fe0a2c94
|
17
|
|
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation, file e309ade3-8d6b-3969-e053-3a05fe0a2c94
|
10
|
|
3-Aryl/Heteroaryl-5-amino-1-(3′,4′,5′-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization, file e309ade5-0e62-3969-e053-3a05fe0a2c94
|
10
|
|
History and perspectives of A2A adenosine receptor antagonists as potential therapeutic agents, file e309ade0-cb8f-3969-e053-3a05fe0a2c94
|
9
|
|
Medicinal chemistry, pharmacology, and potential therapeutic benefits of cannabinoid CB2receptor agonists, file e309ade0-bb4c-3969-e053-3a05fe0a2c94
|
8
|
|
null, file e309ade0-cb9c-3969-e053-3a05fe0a2c94
|
8
|
|
Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety, file e309ade1-1c25-3969-e053-3a05fe0a2c94
|
7
|
|
Ethyl 5-substituted-3-isoxazole carboxvyates as starting materials for a convenient route to 3(2H )-furanones and 3(2H )-iminofuranes, file 82a6567f-2605-4b03-9d40-109cd9c8d2f6
|
6
|
|
Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists, file e309ade1-89ac-3969-e053-3a05fe0a2c94
|
6
|
|
A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy, file e309ade1-fb1d-3969-e053-3a05fe0a2c94
|
6
|
|
Facile access to 2'-O-acyl prodrugs of 1-(β-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil (BVAraU) via regioselective esterase-catalyzed hydrolysis of 2',3',5'-triesters, file 446ddeae-dba1-4d8c-ae70-8f028f9fa30e
|
5
|
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Synthesis of 2-(5-substituted isoxazol-3-yl)-4-oxo-3-thiazolidinyl alkanoic acids, file 45587ed3-862f-49a2-b155-cc7ebcb1b171
|
5
|
|
Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin, file e309ade0-5d19-3969-e053-3a05fe0a2c94
|
5
|
|
One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists, file e309ade0-7e5c-3969-e053-3a05fe0a2c94
|
5
|
|
7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB2 Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists, file e309ade0-ccd8-3969-e053-3a05fe0a2c94
|
5
|
|
A3 adenosine receptor antagonists: History and future perspectives, file e309ade1-88ae-3969-e053-3a05fe0a2c94
|
5
|
|
Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4- substituted thiophenes as allosteric enhancers of the A1 adenosine receptor, file e309ade2-bea4-3969-e053-3a05fe0a2c94
|
5
|
|
Ethyl 2,4-dioxoalkanoates as starting materials for a convenient route to 3(2H)-furanones and 3(2H)-furanimines, file 3238c2b0-a078-4b07-86c9-107a45cab762
|
4
|
|
A [3 + 2] nitrile oxide cycloaddition approach to retinoids, file 61f20c50-6ca3-4b22-816c-627ffd0fb153
|
4
|
|
Allosteric modulation of A1-adenosine receptor: A review, file e309ade0-4035-3969-e053-3a05fe0a2c94
|
4
|
|
Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione, file e309ade0-46f7-3969-e053-3a05fe0a2c94
|
4
|
|
Partition coefficients of 3-methyl-4-nitropyrazole-5-carboxamides, file e309ade0-c247-3969-e053-3a05fe0a2c94
|
4
|
|
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor, file e309ade0-cb8b-3969-e053-3a05fe0a2c94
|
4
|
|
7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: A promising approach for treating pain and inflammation, file e309ade0-cb90-3969-e053-3a05fe0a2c94
|
4
|
|
Synthesis and Structure Activity Relationship Investigation of Triazolo[1,5-a]pyrimidines as CB2 Cannabinoid Receptor Inverse Agonists, file e309ade1-151a-3969-e053-3a05fe0a2c94
|
4
|
|
Synthesis and Biological Evaluation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno[2,3-b]pyridines as New Potent Anticancer Agents, file e309ade2-beae-3969-e053-3a05fe0a2c94
|
4
|
|
Water-Soluble Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as Human A3 Adenosine Receptor Antagonists, file e309ade0-2fe0-3969-e053-3a05fe0a2c94
|
3
|
|
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4- arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor, file e309ade0-3ba0-3969-e053-3a05fe0a2c94
|
3
|
|
null, file e309ade0-a439-3969-e053-3a05fe0a2c94
|
3
|
|
Protection by pyroglutamic acid and some of its newly synthesized derivatives against glutamate-induced seizures in mice, file e309ade0-c073-3969-e053-3a05fe0a2c94
|
3
|
|
A formal total synthesis (±)-forskolin through [3+2] nitrile oxide cycloaddition chemistry, file e309ade0-c553-3969-e053-3a05fe0a2c94
|
3
|
|
null, file e309ade1-2d29-3969-e053-3a05fe0a2c94
|
3
|
|
A2B AND A3 ADENOSINE RECEPTORS MODULATE VASCULAR ENDOTHELIAL GROWTH FACTOR AND INTERLEUKIN-8 EXPRESSION IN HUMAN MELANOMA CELLS TREATED WITH ETOPOSIDE AND DOXORUBICIN., file e309ade2-379c-3969-e053-3a05fe0a2c94
|
3
|
|
Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors, file e309ade2-a0d7-3969-e053-3a05fe0a2c94
|
3
|
|
TR-644 a novel potent tubulin binding agent induces impairment of endothelial cells function and inhibits angiogenesis, file e309ade2-c480-3969-e053-3a05fe0a2c94
|
3
|
|
null, file e309ade0-3b24-3969-e053-3a05fe0a2c94
|
2
|
|
Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4’-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene, file e309ade0-415a-3969-e053-3a05fe0a2c94
|
2
|
|
Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents, file e309ade0-45e8-3969-e053-3a05fe0a2c94
|
2
|
|
Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study, file e309ade0-6f37-3969-e053-3a05fe0a2c94
|
2
|
|
Current status of A1 adenosine receptor allosteric enhancers, file e309ade0-7edc-3969-e053-3a05fe0a2c94
|
2
|
|
Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH), file e309ade0-c408-3969-e053-3a05fe0a2c94
|
2
|
|
null, file e309ade0-c45d-3969-e053-3a05fe0a2c94
|
2
|
|
Synthesis and growth inhibition activity of alpha-bromoacrylic heterocyclic and benzoheterocyclic derivatives of distamycin A modified on the amidino moiety, file e309ade0-f557-3969-e053-3a05fe0a2c94
|
2
|
|
Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents, file e309ade1-582b-3969-e053-3a05fe0a2c94
|
2
|
|
A new nitrile oxide based synthesis of the antitumor agent geiparvarin, file 0e152f2c-b573-49dd-ae08-87059463d23c
|
1
|
|
Pyrazole-related nucleosides. Design, synthesis and antiproliferative activity of methyl 4-Iodo-1-beta-D-ribofuranosylpyrazole-3-carboxylate (IPCAR), and derivatives, against human leukemias, lymphomas and solid tumors cell lines in vitro, file b04f077f-fef6-4380-b385-73976283d9d0
|
1
|
|
Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1α, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells, file e309ade0-25de-3969-e053-3a05fe0a2c94
|
1
|
|
null, file e309ade0-4754-3969-e053-3a05fe0a2c94
|
1
|
|
null, file e309ade0-47e1-3969-e053-3a05fe0a2c94
|
1
|
|
null, file e309ade0-485d-3969-e053-3a05fe0a2c94
|
1
|
|
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation, file e309ade0-a3bb-3969-e053-3a05fe0a2c94
|
1
|
|
New synthesis of diazepino[3,2,1-ij]quinoline and pyrido[1,2,3-de] quinoxalines via addition-elimination followed by cycloacylation, file e309ade0-b67b-3969-e053-3a05fe0a2c94
|
1
|
|
null, file e309ade0-c17a-3969-e053-3a05fe0a2c94
|
1
|
|
Inhibition of NF-kB/DNA Interactions and HIV-1 LTR Directed Transcription by Hybrid Molecules Containing Pyrrolo [2,1-c] [1,4] Benzodiazepine (PBD) and Oligopyrrole Carriers, file e309ade0-eb05-3969-e053-3a05fe0a2c94
|
1
|
|
Binding of hybrid molecules containing pyrrolo [2,1-c][1,4]benzodiazepine (PBD) and oligopyrrole carriers to the human immunodeficiency type 1 virus TAR-RNA, file e309ade0-eb86-3969-e053-3a05fe0a2c94
|
1
|
|
Design, synthesis and biological activity of 5-fluorouracil-distamycin hybrids, file e309ade0-ec0a-3969-e053-3a05fe0a2c94
|
1
|
|
Design, synthesis and growth inhibition activity of bis-epoxyethyl derivatives of stallimycin modified on the amidino moiety, file e309ade0-edcf-3969-e053-3a05fe0a2c94
|
1
|
|
Bis-epoxyethyl derivatives of distamycin A modified on the amidino moiety: Induction of production of fetal hemoglobin in human erythroid precursor cells, file e309ade0-f42c-3969-e053-3a05fe0a2c94
|
1
|
|
Benzoyl nitrogen mustard derivatives of benzoheterocyclic analogues of netropsin: Synthesis and biological activity, file e309ade0-f559-3969-e053-3a05fe0a2c94
|
1
|
|
3-Aryl/Heteroaryl-5-amino-1-(3′,4′,5′-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization, file e309ade1-d9a9-3969-e053-3a05fe0a2c94
|
1
|
|
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors, file e309ade2-2424-3969-e053-3a05fe0a2c94
|
1
|
|
A 2a adenosine receptor: Structures, modeling, and medicinal chemistry, file e309ade2-a183-3969-e053-3a05fe0a2c94
|
1
|
|
Isoxazole-mediated synthesis of geiparvarin and dihydrogeiparvarin, file e309ade4-d76a-3969-e053-3a05fe0a2c94
|
1
|
|
Antimicrobial and antitumor activity of N-heteroimmine-1,2,3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines, file e309ade4-f1bd-3969-e053-3a05fe0a2c94
|
1
|
| Totale |
2.528 |