Pathologic and molecular features of BRAF mutated colorectal adenocarcinomas

There is growing evidence of the diagnostic, prognostic and predictive role of BRAF mutation in colorectal cancer. BRAF mutation, together with MSI and CIMP, is also a key feature of large bowel tumors that develop through the serrated pathway. Aim of this study was to examine the clinical and pathological features associated with BRAF mutated colorectal cancers in relation to microsatellite instability status and to compare in the group of Mismatch Repair proficient (MMR-P) carcinomas the characteristics of BRAF-mutated, KRAS-mutated and KRAS/BRAF-wild type tumors.