| Nome |
# |
|
A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy, file e309ade2-c09e-3969-e053-3a05fe0a2c94
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154
|
|
Effects of Pimozide Derivatives on pSTAT5 in K562 Cells, file e309ade3-a2a0-3969-e053-3a05fe0a2c94
|
130
|
|
Design and Synthesis of Potent in Vitro and in Vivo Anticancer Agents Based on 1-(3’,4’,5’-Trimethoxyphenyl)-2-Aryl-1H-Imidazole, file e309ade0-d8e0-3969-e053-3a05fe0a2c94
|
70
|
|
Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach, file e309ade1-e366-3969-e053-3a05fe0a2c94
|
57
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|
Synthesis and Biological Evaluation of 2-Methyl-4,5-Disubstituted Oxazoles as a Novel Class of Highly Potent Antitubulin Agents, file e309ade1-5591-3969-e053-3a05fe0a2c94
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52
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|
Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents, file e309ade3-9be9-3969-e053-3a05fe0a2c94
|
50
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|
Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells, file e309ade1-ce26-3969-e053-3a05fe0a2c94
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45
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|
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors, file e309ade5-37c9-3969-e053-3a05fe0a2c94
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35
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Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety, file e309ade3-b282-3969-e053-3a05fe0a2c94
|
30
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|
Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds, file e309ade3-94ea-3969-e053-3a05fe0a2c94
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26
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Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin, file e309ade3-956d-3969-e053-3a05fe0a2c94
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24
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Current status of A1 adenosine receptor allosteric enhancers, file e309ade3-dddf-3969-e053-3a05fe0a2c94
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21
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|
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors, file e309ade4-e60b-3969-e053-3a05fe0a2c94
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21
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|
Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization, file e309ade2-8100-3969-e053-3a05fe0a2c94
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20
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|
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor, file e309ade3-cfd0-3969-e053-3a05fe0a2c94
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19
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|
Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study, file e309ade3-ffd2-3969-e053-3a05fe0a2c94
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14
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2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition, file e309ade3-9385-3969-e053-3a05fe0a2c94
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13
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Thioridazine requires calcium influx to induce MLL-AF6-rearranged AML cell death, file bfee7d23-bb98-448f-90ef-5c2ad2dc254a
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11
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A Facile Synthesis of Diaryl Pyrroles Led to the Discovery of Potent Colchicine Site Antimitotic Agents, file e309ade3-5f06-3969-e053-3a05fe0a2c94
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11
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Synthesis and biological evaluation of new antitubulin agents containing 2-(30,40,50-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold, file e309ade2-9b91-3969-e053-3a05fe0a2c94
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10
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|
The Detrimental Action of Adenosine on Glutamate-Induced Cytotoxicity in PC12 Cells Can Be Shifted towards a Neuroprotective Role through A1AR Positive Allosteric Modulation, file e309ade3-0748-3969-e053-3a05fe0a2c94
|
10
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|
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation, file e309ade3-8d6b-3969-e053-3a05fe0a2c94
|
10
|
|
Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors, file 2ffd3d25-7e35-4ed6-981b-d7480817070d
|
9
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|
Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors, file 8195c995-8220-43c0-9993-5063de1a7e9e
|
9
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|
The new iodoacetamidobenzofuran derivative TR120 decreases STAT5 expression and induces antitumor effects in imatinib-sensitive and imatinib-resistant BCR-ABL-expressing leukemia cells, file e309ade1-530f-3969-e053-3a05fe0a2c94
|
9
|
|
3-Aryl/Heteroaryl-5-amino-1-(3′,4′,5′-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization, file e309ade5-0e62-3969-e053-3a05fe0a2c94
|
9
|
|
null, file e309ade0-cb9c-3969-e053-3a05fe0a2c94
|
8
|
|
Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety, file e309ade1-1c25-3969-e053-3a05fe0a2c94
|
7
|
|
Thio-substituted derivatives of 4-amino-pyrazolo[3,4-d]pyrimidine-6-thiol as antiproliferative agents, file e309ade4-82bd-3969-e053-3a05fe0a2c94
|
7
|
|
Anticancer activity of novel hybrid molecules containing 5-benzylidene thiazolidine-2,4-dione, file e309ade0-46f7-3969-e053-3a05fe0a2c94
|
6
|
|
A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy, file e309ade1-fb1d-3969-e053-3a05fe0a2c94
|
6
|
|
Synthesis and biological evaluation of 2-substituted benzyl-/phenylethylamino-4-amino-5-aroylthiazoles as apoptosis-inducing anticancer agents, file e309ade2-9d61-3969-e053-3a05fe0a2c94
|
6
|
|
Thioridazine requires calcium influx to induce MLL-AF6-rearranged AML cell death, file e309ade2-b269-3969-e053-3a05fe0a2c94
|
6
|
|
Design, synthesis, in vitro, and in vivo anticancer and antiangiogenic activity of novel 3-arylaminobenzofuran derivatives targeting the colchicine site on tubulin, file e309ade0-5d19-3969-e053-3a05fe0a2c94
|
5
|
|
One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists, file e309ade0-7e5c-3969-e053-3a05fe0a2c94
|
5
|
|
7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB2 Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists, file e309ade0-ccd8-3969-e053-3a05fe0a2c94
|
5
|
|
A3 adenosine receptor antagonists: History and future perspectives, file e309ade1-88ae-3969-e053-3a05fe0a2c94
|
5
|
|
Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4- substituted thiophenes as allosteric enhancers of the A1 adenosine receptor, file e309ade2-bea4-3969-e053-3a05fe0a2c94
|
5
|
|
Allosteric modulation of A1-adenosine receptor: A review, file e309ade0-4035-3969-e053-3a05fe0a2c94
|
4
|
|
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor, file e309ade0-cb8b-3969-e053-3a05fe0a2c94
|
4
|
|
7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: A promising approach for treating pain and inflammation, file e309ade0-cb90-3969-e053-3a05fe0a2c94
|
4
|
|
Synthesis and Biological Evaluation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno[2,3-b]pyridines as New Potent Anticancer Agents, file e309ade2-beae-3969-e053-3a05fe0a2c94
|
4
|
|
Synergistic effects of the combined treatment of U251 and T98G glioma cells with an anti-tubulin tetrahydrothieno[2,3-c]pyridine derivative and a peptide nucleic acid targeting miR-221-3p, file e309ade4-d2eb-3969-e053-3a05fe0a2c94
|
4
|
|
Apoptosis Pathways Triggered by a Potent Antiproliferative Hybrid Chalcone on Human Melanoma Cells, file e309ade4-f1dc-3969-e053-3a05fe0a2c94
|
4
|
|
Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents, file e309ade5-675e-3969-e053-3a05fe0a2c94
|
4
|
|
Water-Soluble Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as Human A3 Adenosine Receptor Antagonists, file e309ade0-2fe0-3969-e053-3a05fe0a2c94
|
3
|
|
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4- arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor, file e309ade0-3ba0-3969-e053-3a05fe0a2c94
|
3
|
|
null, file e309ade0-a439-3969-e053-3a05fe0a2c94
|
3
|
|
The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation, file e309ade1-2364-3969-e053-3a05fe0a2c94
|
3
|
|
null, file e309ade1-2d29-3969-e053-3a05fe0a2c94
|
3
|
|
2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition, file e309ade1-8e8e-3969-e053-3a05fe0a2c94
|
3
|
|
Design, synthesis and biological evaluation of novel vicinal diaryl-substituted 1H-Pyrazole analogues of combretastatin A-4 as highly potent tubulin polymerization inhibitors, file e309ade2-4421-3969-e053-3a05fe0a2c94
|
3
|
|
TR-644 a novel potent tubulin binding agent induces impairment of endothelial cells function and inhibits angiogenesis, file e309ade2-c480-3969-e053-3a05fe0a2c94
|
3
|
|
Synergistic Effects of A Combined Treatment of Glioblastoma U251 Cells with An Anti-miR-10b-5p Molecule and An AntiCancer Agent Based on 1-(3',4',5'-Trimethoxyphenyl)-2-Aryl-1H-Imidazole Scaffold, file f887e2be-398f-43ba-b843-928abdb89536
|
3
|
|
Synthesis and Biological Evaluation of Novel Allosteric Enhancers of the A1 Adenosine Receptor Based on 2-Amino-3-(4’-Chlorobenzoyl)-4-Substituted-5-Arylethynyl Thiophene, file e309ade0-415a-3969-e053-3a05fe0a2c94
|
2
|
|
Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents, file e309ade0-45e8-3969-e053-3a05fe0a2c94
|
2
|
|
null, file e309ade0-46ea-3969-e053-3a05fe0a2c94
|
2
|
|
Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study, file e309ade0-6f37-3969-e053-3a05fe0a2c94
|
2
|
|
Current status of A1 adenosine receptor allosteric enhancers, file e309ade0-7edc-3969-e053-3a05fe0a2c94
|
2
|
|
Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH), file e309ade0-c408-3969-e053-3a05fe0a2c94
|
2
|
|
null, file e309ade0-c45d-3969-e053-3a05fe0a2c94
|
2
|
|
Synthesis and growth inhibition activity of alpha-bromoacrylic heterocyclic and benzoheterocyclic derivatives of distamycin A modified on the amidino moiety, file e309ade0-f557-3969-e053-3a05fe0a2c94
|
2
|
|
Design, synthesis and biological evaluation of 3-substituted-2-oxindole hybrid derivatives as novel anticancer agents, file e309ade1-582b-3969-e053-3a05fe0a2c94
|
2
|
|
A Facile Synthesis of Diaryl Pyrroles Led to the Discovery of Potent Colchicine Site Antimitotic Agents, file e309ade3-5f05-3969-e053-3a05fe0a2c94
|
2
|
|
Effects of Pimozide Derivatives on pSTAT5 in K562 Cells, file e309ade3-99a9-3969-e053-3a05fe0a2c94
|
2
|
|
Cinnamic acid derivatives linked to arylpiperazines as novel potent inhibitors of tyrosinase activity and melanin synthesis, file e309ade5-401c-3969-e053-3a05fe0a2c94
|
2
|
|
Design, Synthesis and Biological Investigation of 2-Anilino Triazolopyrimidines as Tubulin Polymerization Inhibitors with Anticancer Activities, file 649693de-449a-45ff-b25c-9e1f5e793355
|
1
|
|
Design, synthesis, in vitro and in vivo biological evaluation of 2-amino-3-aroylbenzo[b]furan derivatives as highly potent tubulin polymerization inhibitors, file 76b1ec24-1e88-4d08-aded-41e6b2c8aca9
|
1
|
|
null, file e309ade0-4754-3969-e053-3a05fe0a2c94
|
1
|
|
null, file e309ade0-47e1-3969-e053-3a05fe0a2c94
|
1
|
|
null, file e309ade0-485d-3969-e053-3a05fe0a2c94
|
1
|
|
Novel iodoacetamido benzoheterocyclic derivatives with potent antileukemic activity are inhibitors of STAT5 phosphorylation, file e309ade0-a3bb-3969-e053-3a05fe0a2c94
|
1
|
|
null, file e309ade0-d506-3969-e053-3a05fe0a2c94
|
1
|
|
Inhibition of NF-kB/DNA Interactions and HIV-1 LTR Directed Transcription by Hybrid Molecules Containing Pyrrolo [2,1-c] [1,4] Benzodiazepine (PBD) and Oligopyrrole Carriers, file e309ade0-eb05-3969-e053-3a05fe0a2c94
|
1
|
|
Binding of hybrid molecules containing pyrrolo [2,1-c][1,4]benzodiazepine (PBD) and oligopyrrole carriers to the human immunodeficiency type 1 virus TAR-RNA, file e309ade0-eb86-3969-e053-3a05fe0a2c94
|
1
|
|
Design, synthesis and biological activity of 5-fluorouracil-distamycin hybrids, file e309ade0-ec0a-3969-e053-3a05fe0a2c94
|
1
|
|
Design, synthesis and growth inhibition activity of bis-epoxyethyl derivatives of stallimycin modified on the amidino moiety, file e309ade0-edcf-3969-e053-3a05fe0a2c94
|
1
|
|
Bis-epoxyethyl derivatives of distamycin A modified on the amidino moiety: Induction of production of fetal hemoglobin in human erythroid precursor cells, file e309ade0-f42c-3969-e053-3a05fe0a2c94
|
1
|
|
Benzoyl nitrogen mustard derivatives of benzoheterocyclic analogues of netropsin: Synthesis and biological activity, file e309ade0-f559-3969-e053-3a05fe0a2c94
|
1
|
|
3-Aryl/Heteroaryl-5-amino-1-(3′,4′,5′-trimethoxybenzoyl)-1,2,4-triazoles as antimicrotubule agents. Design, synthesis, antiproliferative activity and inhibition of tubulin polymerization, file e309ade1-d9a9-3969-e053-3a05fe0a2c94
|
1
|
|
Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors, file e309ade2-2424-3969-e053-3a05fe0a2c94
|
1
|
|
Concise synthesis and biological evaluation of 2-Aryl-3-Anilinobenzo[b]thiophene derivatives as potent apoptosis-inducing agents, file e309ade4-2979-3969-e053-3a05fe0a2c94
|
1
|
|
Antimicrobial and antitumor activity of N-heteroimmine-1,2,3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines, file e309ade4-f1bd-3969-e053-3a05fe0a2c94
|
1
|
| Totale |
1.036 |