| Nome |
# |
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The A3 adenosine receptor: history and perspectives, file e309ade2-c090-3969-e053-3a05fe0a2c94
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639
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Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors, file 391d3d69-eb70-4beb-85f4-3b749c9db1fc
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308
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A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy, file e309ade2-c09e-3969-e053-3a05fe0a2c94
|
206
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Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?, file e309ade3-ab46-3969-e053-3a05fe0a2c94
|
191
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|
Medicinal chemistry, pharmacology, and potential therapeutic benefits of cannabinoid CB2receptor agonists, file e309ade3-e598-3969-e053-3a05fe0a2c94
|
191
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|
Cannabigerol action at cannabinoid CB1 and CB2 receptors and at CB1-CB2 heteroreceptor complexes, file e309ade1-ffe9-3969-e053-3a05fe0a2c94
|
179
|
|
History and perspectives of A2A adenosine receptor antagonists as potential therapeutic agents, file e309ade3-e533-3969-e053-3a05fe0a2c94
|
152
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|
“Bridging the Gap” Everything that Could Have Been Avoided If We Had Applied Gender Medicine, Pharmacogenetics and Personalized Medicine in the Gender-Omics and Sex-Omics Era, file e309ade2-683b-3969-e053-3a05fe0a2c94
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146
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Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies, file e309ade3-ff1b-3969-e053-3a05fe0a2c94
|
136
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|
Targeting A3 and A2A adenosine receptors in the fight against cancer, file e309ade3-9ab5-3969-e053-3a05fe0a2c94
|
128
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|
Pulsed electromagnetic field and relief of hypoxia-induced neuronal cell death: The signaling pathway, file e309ade4-2758-3969-e053-3a05fe0a2c94
|
125
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Pulsed Electromagnetic Field Exposure Reduces Hypoxia and Inflammation Damage in Neuron-Like and Microglial Cells, file e309ade4-3d6d-3969-e053-3a05fe0a2c94
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118
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|
Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A2A Adenosine Receptor Inverse Agonists with Antinociceptive Activity, file e309ade3-fb3e-3969-e053-3a05fe0a2c94
|
110
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Pharmacology of Adenosine Receptors: The State of the Art, file e309ade1-e760-3969-e053-3a05fe0a2c94
|
89
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Pharmaco-toxicological effects of the novel third-generation fluorinate synthetic cannabinoids, 5F-ADBINACA, AB-FUBINACA, and STS-135 in mice. In vitro and in vivo studies, file e309ade1-6b6d-3969-e053-3a05fe0a2c94
|
85
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Inhibition of A2A Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455, file e309ade1-8c14-3969-e053-3a05fe0a2c94
|
80
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|
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice, file e309ade1-5825-3969-e053-3a05fe0a2c94
|
73
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|
A(2B) adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPK kinase pathway, file e309ade3-a9ed-3969-e053-3a05fe0a2c94
|
71
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|
Effect of JWH-250, JWH-073 and their interaction on “tetrad”, sensorimotor, neurological and neurochemical responses in mice, file e309ade3-b5f2-3969-e053-3a05fe0a2c94
|
70
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|
Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents, file 24fb7932-0127-4268-ae7a-efc4b2237396
|
68
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|
Pathological overproduction: the bad side of adenosine, file e309ade2-65f7-3969-e053-3a05fe0a2c94
|
66
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|
Binding and signaling studies disclose a potential allosteric site for cannabidiol in cannabinoid CB2 receptors, file e309ade1-a888-3969-e053-3a05fe0a2c94
|
62
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|
The activation of μ-opioid receptor potentiates LPS-induced NF-kB promoting an inflammatory phenotype in microglia, file e309ade1-1e52-3969-e053-3a05fe0a2c94
|
57
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Role and function of A2A and A3 adenosine receptors in patients with ankylosing spondylitis, psoriatic arthritis and rheumatoid arthritis, file e309ade1-4cf1-3969-e053-3a05fe0a2c94
|
57
|
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Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety, file e309ade3-b282-3969-e053-3a05fe0a2c94
|
55
|
|
L-DOPA promotes striatal dopamine release through D1 receptors and reversal of dopamine transporter, file e309ade5-0769-3969-e053-3a05fe0a2c94
|
49
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|
Alteration of adenosine receptore in patients with chronic obstructive pulmonary disease, file e309ade4-913f-3969-e053-3a05fe0a2c94
|
44
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|
Piperazine-and piperidine-containing thiazolo[5,4-d]pyrimidine derivatives as new potent and selective adenosine a2a receptor inverse agonists, file e309ade3-059a-3969-e053-3a05fe0a2c94
|
43
|
|
Novel halogenated derivates of JWH-018: Behavioral and binding studies in mice, file e309ade3-fb5f-3969-e053-3a05fe0a2c94
|
43
|
|
Amino-3, 5-dicyanopyridines targeting the adenosine receptors ranging from pan ligands to combined A1/A2B partial agonists, file e309ade2-62dd-3969-e053-3a05fe0a2c94
|
41
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The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor, file e309ade3-e97c-3969-e053-3a05fe0a2c94
|
40
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A(2B) adenosine receptors stimulate IL-6 production in primary murine microglia through p38 MAPK kinase pathway, file e309ade1-1afc-3969-e053-3a05fe0a2c94
|
37
|
|
Synthesis and Structure Activity Relationship Investigation of Triazolo[1,5-a]pyrimidines as CB2 Cannabinoid Receptor Inverse Agonists, file e309ade3-ff5f-3969-e053-3a05fe0a2c94
|
37
|
|
Characterization of A2A Adenosine Receptors in Human Lymphocyte Membranes by [3H]-SCH 58261 Binding, file e309ade4-e240-3969-e053-3a05fe0a2c94
|
35
|
|
Adenosine and inflammation: Here, there and everywhere, file e309ade5-12d6-3969-e053-3a05fe0a2c94
|
34
|
|
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor, file e309ade3-cfd0-3969-e053-3a05fe0a2c94
|
29
|
|
Current status of A1 adenosine receptor allosteric enhancers, file e309ade3-dddf-3969-e053-3a05fe0a2c94
|
29
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|
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2Aadenosine receptor, file e309ade3-fccd-3969-e053-3a05fe0a2c94
|
23
|
|
Psychostimulant effect of the synthetic cannabinoid JWH-018 and AKB48. Behavioural, neurochemical and Dopamine transporter scan imaging studies in mice, file e309ade1-815a-3969-e053-3a05fe0a2c94
|
22
|
|
Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?, file e309ade1-123c-3969-e053-3a05fe0a2c94
|
21
|
|
Modifications on the amino-3,5-dicyanopyridine core to obtain multifaceted adenosine receptor ligands with antineuropathic activity, file e309ade3-468d-3969-e053-3a05fe0a2c94
|
21
|
|
Synthesis and biological evaluation of a new series of 2-amino-3-aroyl thiophene derivatives as agonist allosteric modulators of the A1 adenosine receptor. A position-dependent effect study, file e309ade3-ffd2-3969-e053-3a05fe0a2c94
|
20
|
|
Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice, file e309ade5-7160-3969-e053-3a05fe0a2c94
|
17
|
|
A1 Adenosine Receptor Partial Agonists and Allosteric Modulators: Advancing Toward the Clinic?, file e309ade3-6629-3969-e053-3a05fe0a2c94
|
13
|
|
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of alpha 7 and alpha 3*Nicotinic Receptors, file e309ade5-22a6-3969-e053-3a05fe0a2c94
|
13
|
|
A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases, file 47e1a918-5dec-4787-a9c7-8cdce4bd1e10
|
11
|
|
The Detrimental Action of Adenosine on Glutamate-Induced Cytotoxicity in PC12 Cells Can Be Shifted towards a Neuroprotective Role through A1AR Positive Allosteric Modulation, file e309ade3-0748-3969-e053-3a05fe0a2c94
|
11
|
|
Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice, file e309ade4-db90-3969-e053-3a05fe0a2c94
|
11
|
|
A2A adenosine receptors are involved in the reparative response of tendon cells to pulsed electromagnetic fields, file e309ade2-feac-3969-e053-3a05fe0a2c94
|
10
|
|
Targeting adenosine receptors: A potential pharmacological avenue for acute and chronic pain, file e309ade3-03eb-3969-e053-3a05fe0a2c94
|
10
|
|
Pathophysiological Role and Medicinal Chemistry of A2A Adenosine Receptor Antagonists in Alzheimer's Disease, file 45e403cd-91ef-4371-8e90-1b4e18f54711
|
9
|
|
Expression and functional role of adenosine receptors in regulating inflammatory responses in human synoviocytes., file 520009a3-3561-4184-adb5-18cb458e23fc
|
9
|
|
History and perspectives of A2A adenosine receptor antagonists as potential therapeutic agents, file e309ade0-cb8f-3969-e053-3a05fe0a2c94
|
9
|
|
Pulsed electromagnetic fields stimulate hif-1α-independent vegf release in 1321n1 human astrocytes protecting neuron-like sh-sy5y cells from oxygen-glucose deprivation, file e309ade3-0044-3969-e053-3a05fe0a2c94
|
9
|
|
Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic Implications, file e309ade3-c957-3969-e053-3a05fe0a2c94
|
9
|
|
A2A Adenosine Receptor as a Potential Biomarker and a Possible Therapeutic Target in Alzheimer's Disease, file e309ade4-eee0-3969-e053-3a05fe0a2c94
|
9
|
|
A3 Adenosine and P2X7 Purinergic Receptors as New Targets for an Innovative Pharmacological Therapy of Malignant Pleural Mesothelioma, file e309ade5-3b64-3969-e053-3a05fe0a2c94
|
9
|
|
Medicinal chemistry, pharmacology, and potential therapeutic benefits of cannabinoid CB2receptor agonists, file e309ade0-bb4c-3969-e053-3a05fe0a2c94
|
8
|
|
null, file e309ade0-cb9c-3969-e053-3a05fe0a2c94
|
8
|
|
Adenosinergic System Involvement in Ischemic Stroke Patients' Lymphocytes, file e309ade2-ff4f-3969-e053-3a05fe0a2c94
|
8
|
|
Adenosine Receptors in Neuropsychiatric Disorders: Fine Regulators of Neurotransmission and Potential Therapeutic Targets, file e309ade5-4959-3969-e053-3a05fe0a2c94
|
8
|
|
4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives, file e309ade5-5c53-3969-e053-3a05fe0a2c94
|
8
|
|
MAM-2201 acute administration impairs motor, sensorimotor, prepulse inhibition, and memory functions in mice: a comparison with its analogue AM-2201, file 3d79e4e1-e302-4409-9559-6ae451f1e7db
|
7
|
|
A2A Adenosine Receptor: A Possible Therapeutic Target for Alzheimer's Disease by Regulating NLRP3 Inflammasome Activity?, file 78945b54-b81c-49ca-9d9e-5b0e5dad3ec5
|
7
|
|
Positive allosteric modulation of A1 adenosine receptors as a novel and promising therapeutic strategy for anxiety, file e309ade1-1c25-3969-e053-3a05fe0a2c94
|
7
|
|
An Open Question: Is the A2A Adenosine Receptor a Novel Target for Alzheimer's Disease Treatment?, file e309ade5-092b-3969-e053-3a05fe0a2c94
|
7
|
|
P2X1 and P2X3 Purinergic Receptors Differentially Modulate the Inflammatory Response in Human Osteoarthritic Synovial Fibroblasts, file e729e9fb-0ca0-40df-b7b3-9ce232309374
|
7
|
|
Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition, file 337d4dde-0d37-4ec6-8b08-e555e6c6cadd
|
6
|
|
Update on the recent development of allosteric modulators for adenosine receptors and their therapeutic applications, file 8f1e7d19-de62-4a57-b58e-a1a705194da6
|
6
|
|
A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy, file e309ade1-fb1d-3969-e053-3a05fe0a2c94
|
6
|
|
In Vivo Bio-Activation of JWH-175 to JWH-018: Pharmacodynamic and Pharmacokinetic Studies in Mice, file a9411c31-ba91-41e4-ad8d-148d4d3b95f7
|
5
|
|
Novel halogenated derivates of JWH-018: Behavioral and binding studies in mice, file e309ade0-20c3-3969-e053-3a05fe0a2c94
|
5
|
|
One-pot reaction to obtain N,N'-disubstituted guanidines of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine scaffold as human A3 adenosine receptor antagonists, file e309ade0-7e5c-3969-e053-3a05fe0a2c94
|
5
|
|
7-Oxo-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxamides as Selective CB2 Cannabinoid Receptor Ligands: Structural Investigations around a Novel Class of Full Agonists, file e309ade0-ccd8-3969-e053-3a05fe0a2c94
|
5
|
|
Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A2A Adenosine Receptor Inverse Agonists with Antinociceptive Activity, file e309ade1-14b4-3969-e053-3a05fe0a2c94
|
5
|
|
null, file e309ade1-1910-3969-e053-3a05fe0a2c94
|
5
|
|
Synthesis and biological effects of novel 2-amino-3-(4-chlorobenzoyl)-4- substituted thiophenes as allosteric enhancers of the A1 adenosine receptor, file e309ade2-bea4-3969-e053-3a05fe0a2c94
|
5
|
|
Caffeine for Prevention of Alzheimer's Disease: Is the A2A Adenosine Receptor Its Target?, file 009ed723-46c6-4692-8f84-264d88948212
|
4
|
|
Functional tissue engineering in articular cartilage repair: is there a role for electromagnetic biophysical stimulation?, file e309ade0-9f18-3969-e053-3a05fe0a2c94
|
4
|
|
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor, file e309ade0-cb8b-3969-e053-3a05fe0a2c94
|
4
|
|
Synthesis and Structure Activity Relationship Investigation of Triazolo[1,5-a]pyrimidines as CB2 Cannabinoid Receptor Inverse Agonists, file e309ade1-151a-3969-e053-3a05fe0a2c94
|
4
|
|
Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on “tetrad”, sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies, file e309ade1-1902-3969-e053-3a05fe0a2c94
|
4
|
|
null, file e309ade1-1fd5-3969-e053-3a05fe0a2c94
|
4
|
|
Targeting A3 and A2A adenosine receptors in the fight against cancer, file e309ade2-8c27-3969-e053-3a05fe0a2c94
|
4
|
|
Adenosine analogs and electromagnetic fields inhibit prostaglandin E2 release in bovine synovial fibroblasts, file e309ade0-2870-3969-e053-3a05fe0a2c94
|
3
|
|
Water-Soluble Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines as Human A3 Adenosine Receptor Antagonists, file e309ade0-2fe0-3969-e053-3a05fe0a2c94
|
3
|
|
Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4- arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. Effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor, file e309ade0-3ba0-3969-e053-3a05fe0a2c94
|
3
|
|
null, file e309ade0-a439-3969-e053-3a05fe0a2c94
|
3
|
|
Deregulation of Adenosine Receptors in Psoriatic Epidermis: An Option for Therapeutic Treatment, file e309ade1-1769-3969-e053-3a05fe0a2c94
|
3
|
|
Adenosine Receptors as a Biological Pathway for the Anti-Inflammatory and Beneficial Effects of Low Frequency Low Energy Pulsed Electromagnetic Fields, file e309ade1-4195-3969-e053-3a05fe0a2c94
|
3
|
|
Effect of JWH-250, JWH-073 and their interaction on “tetrad”, sensorimotor, neurological and neurochemical responses in mice, file e309ade1-a822-3969-e053-3a05fe0a2c94
|
3
|
|
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2Aadenosine receptor, file e309ade1-ffeb-3969-e053-3a05fe0a2c94
|
3
|
|
A2B AND A3 ADENOSINE RECEPTORS MODULATE VASCULAR ENDOTHELIAL GROWTH FACTOR AND INTERLEUKIN-8 EXPRESSION IN HUMAN MELANOMA CELLS TREATED WITH ETOPOSIDE AND DOXORUBICIN., file e309ade2-379c-3969-e053-3a05fe0a2c94
|
3
|
|
Modifications on the amino-3,5-dicyanopyridine core to obtain multifaceted adenosine receptor ligands with antineuropathic activity, file e309ade2-61ef-3969-e053-3a05fe0a2c94
|
3
|
|
A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases, file e309ade4-e8d8-3969-e053-3a05fe0a2c94
|
3
|
|
Electrophysiological basis for the enhanced cardiac arrhythmogenic effect of isoprenaline in aged spontaneously hypertensive rats, file e5563586-bfe2-453d-8d2b-771d28d9933d
|
3
|
|
Combined targeting of fatty acid amide hydrolase and melatonin receptors promotes neuroprotection and stimulates inflammation resolution in rats, file 9501b3fc-1f62-4905-a452-06c7d2800a98
|
2
|
|
6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors, file e309ade0-2a46-3969-e053-3a05fe0a2c94
|
2
|
|
Expression of A3 adenosine receptors in human lymphocytes: up-regulation in T cell activation, file e309ade0-2cc9-3969-e053-3a05fe0a2c94
|
2
|
|
null, file e309ade0-3b24-3969-e053-3a05fe0a2c94
|
2
|
| Totale |
4.389 |