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EnglishCombined deficiency of the vitamin K-dependent clotting factors (VKCFD) is a rare bleeding disorder involving defective gamma-carboxylation of coagulation factors II , VII, IX and X as well as natural anticoagulants protein C and protein S. The disease is characterized by a cluster of different, often life threatening, bleeding symptoms occurring both spontaneously and in a surgical setting. In the present paper we describe two different treatment modalities to be used both in a programmed surgical procedure and in an emergency scenario. As this disease is a natural model that resembles oral anticoagulation, our experience discloses a possible rationale in the use of recombinant activated FVII for warfarin reversal.
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| Data di pubblicazione: | 2010 | |
| Titolo: | Effective Hemostasis During Minor Surgery in a Case of Hereditary Combined Deficiency of Vitamin K-dependent Clotting Factors. | |
| Autori: | Lapecorella M; Napolitano M; Bernardi F; Pinotti M; Sbrighi P; Marchetti G; Canella A; Caruso P; Orecchioni A; Mariani G. | |
| Rivista: | CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | |
| Parole Chiave: | Hereditary Combined Deficiency of Vitamin K-dependent Clotting Factors | |
| Abstract: | Combined deficiency of the vitamin K-dependent clotting factors (VKCFD) is a rare bleeding disorder involving defective gamma-carboxylation of coagulation factors II , VII, IX and X as well as natural anticoagulants protein C and protein S. The disease is characterized by a cluster of different, often life threatening, bleeding symptoms occurring both spontaneously and in a surgical setting. In the present paper we describe two different treatment modalities to be used both in a programmed surgical procedure and in an emergency scenario. As this disease is a natural model that resembles oral anticoagulation, our experience discloses a possible rationale in the use of recombinant activated FVII for warfarin reversal. | |
| Handle: | http://hdl.handle.net/11392/533122 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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