Background: Lung and esophageal involvements are common in systemic sclerosis (SSc). Aim of this study is to assess if there is a correlation between the involvement of the respiratory and gastrointestinal systems in the same patients.Materials and Methods: We studied 280 patients effected by SSc (259 females and 14 males), with a mean age of 55 years (from 20 to 78 years old) and a mean lenght of disease of 106 months. All pts underwent 99mTc-DTPA clearance using a commercial available jet nebulizer (Venticis, CIS) aerosol inhaling 500 MBq of 99mTc-DTPA aerosol for 2 minutes at normal tiding breathing. Images were recorded dinamically with a dual head camera (Philips Vertex) and two ROIs were defined around lungs and the activity/time curves were generated. The best exponential fit of both curves in the first 15 minutes were calculated: the results were considered abnormal if half time was < 60 minutes. All patients underwent to esophageal transit scintigraphy with the assessment of esophageal transit time of liquid and solid swallows in upright and supine position (10 ml of water or fruit juice labelled with 40 MBq of 99mTc-colloid).
The diagnostic value of 99mTc-DTPA lung clearance and esophageal transit to evaluate the severity of complications in systemic sclerosis
CASALI, Massimiliano;GIGANTI, Melchiore;CITTANTI, Corrado;
2006
Abstract
Background: Lung and esophageal involvements are common in systemic sclerosis (SSc). Aim of this study is to assess if there is a correlation between the involvement of the respiratory and gastrointestinal systems in the same patients.Materials and Methods: We studied 280 patients effected by SSc (259 females and 14 males), with a mean age of 55 years (from 20 to 78 years old) and a mean lenght of disease of 106 months. All pts underwent 99mTc-DTPA clearance using a commercial available jet nebulizer (Venticis, CIS) aerosol inhaling 500 MBq of 99mTc-DTPA aerosol for 2 minutes at normal tiding breathing. Images were recorded dinamically with a dual head camera (Philips Vertex) and two ROIs were defined around lungs and the activity/time curves were generated. The best exponential fit of both curves in the first 15 minutes were calculated: the results were considered abnormal if half time was < 60 minutes. All patients underwent to esophageal transit scintigraphy with the assessment of esophageal transit time of liquid and solid swallows in upright and supine position (10 ml of water or fruit juice labelled with 40 MBq of 99mTc-colloid).I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
