The present work describes the design and preparation of lecithin gels containing methyl nicotinate (MN) and its permeability through the skin. To this aim, an "in vitro" model based on a Franz diffusion cell assembled with a multimembrane system, mimicking human skin, was utilized. Biocompatible solvents, isopropyl-palmitate and isopropyl-avocadate, were used to produce lecithin gels with different viscosities. When incorporated into lecithin gels, MN showed permeability coefficients depending on gel solvent and viscosity. Due to phospholipid presence (that can increase the skin moisture balance) and to the possibility of varying the MN permeability as function of gel viscosity, lecithin gels appear ideally suitable for the production of (trans)dermal vehicles for dermatological and cosmetic use.
Lecithin organogels as cosmetic formulations for methyl nicotinate
ESPOSITO, Elisabetta;CORTESI, Rita;MENEGATTI, Enea;GAMBARI, Roberto;NASTRUZZI, Claudio
1993
Abstract
The present work describes the design and preparation of lecithin gels containing methyl nicotinate (MN) and its permeability through the skin. To this aim, an "in vitro" model based on a Franz diffusion cell assembled with a multimembrane system, mimicking human skin, was utilized. Biocompatible solvents, isopropyl-palmitate and isopropyl-avocadate, were used to produce lecithin gels with different viscosities. When incorporated into lecithin gels, MN showed permeability coefficients depending on gel solvent and viscosity. Due to phospholipid presence (that can increase the skin moisture balance) and to the possibility of varying the MN permeability as function of gel viscosity, lecithin gels appear ideally suitable for the production of (trans)dermal vehicles for dermatological and cosmetic use.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
