4-Methyloxazole and 4,4-dimethyl-2-oxazoline were treated with n-BuLi and trimetìhyltin chloride to give the corresponding 2-trimethylstannyl derivatives which in the presence of Pd(0) undergo cross-coupling reactions with various aryl and heteroaryl derivatives to give 2-aryl and 2-heteroaryl oxazoles and oxazolines in high yields.
Palladium-catalyzed coupling of oxazol-2-yl and oxazolin-2-yl trimethylstannanes with aromatic halides. A new entry to 2-aryl and 2-heteroaryl oxazoles and oxazolines
DONDONI, Alessandro;FANTIN, Giancarlo;FOGAGNOLO, Marco;MEDICI, Alessandro;PEDRINI, Paola
1987
Abstract
4-Methyloxazole and 4,4-dimethyl-2-oxazoline were treated with n-BuLi and trimetìhyltin chloride to give the corresponding 2-trimethylstannyl derivatives which in the presence of Pd(0) undergo cross-coupling reactions with various aryl and heteroaryl derivatives to give 2-aryl and 2-heteroaryl oxazoles and oxazolines in high yields.File in questo prodotto:
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