We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level. © 1984 Academic Press, Inc. All rights reserved.

Human leukemia K562 cells: Relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes

GAMBARI, Roberto;DEL SENNO, Laura;PIVA, Maria Roberta;BERNARDI, Francesco;MARCHETTI, Giovanna;
1984

Abstract

We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level. © 1984 Academic Press, Inc. All rights reserved.
1984
Gambari, Roberto; DEL SENNO, Laura; Piva, Maria Roberta; Barbieri, R; Amelotti, F; Bernardi, Francesco; Marchetti, Giovanna; Citarella, F; Tripodi, M;...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/462230
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