2-Acetylthiazole serves as a source of the alpha-hydroxypropanal beta-anion synton for the conversion of aldehydes into syn and anti alpha, gamma-dihydroxy homologues with three-more carbon atoms via a sequence consisting of: i) aldol condensation of the lithium enolate derived from thiazole; ii) reduction of hydroxy ketone; iii) thiazole to formyl unmasking.
2-ACETYLTHIAZOLE AS A 3-CARBON HOMOLOGATING REAGENT OF ALDEHYDES - APPLICATION TOWARD THE SYNTHESIS OF AMINO HEXOSES FROM L-SERINAL
DONDONI, Alessandro;FANTIN, Giancarlo;FOGAGNOLO, Marco
1989
Abstract
2-Acetylthiazole serves as a source of the alpha-hydroxypropanal beta-anion synton for the conversion of aldehydes into syn and anti alpha, gamma-dihydroxy homologues with three-more carbon atoms via a sequence consisting of: i) aldol condensation of the lithium enolate derived from thiazole; ii) reduction of hydroxy ketone; iii) thiazole to formyl unmasking.File in questo prodotto:
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