A no. of N-​substituted 3-​methyl-​4-​diazo-​5-​pyrazolecarboxamides have been synthesized and tested for their in vitro antibacterial activity. All the compds. have been assayed against several representative gram-​neg. and gram-​pos. bacteria, as well as against some intestinal bacterial species. Some of the 4-​diazopyrazoles have shown a quite interesting broad-​spectrum activity, whereas they are ineffective against the protective intestinal flora. The structure-​activity relationships of the series have been studied quant., via both univariate and multivariate methods: the results are consistent and permit some rationalization of the behavior of the compds. investigated.

Synthesis, antibacterial activity and structure-activity relationships of N-substituted 3-methyl-4-diazo-5-pyrazolecarboxamides.

BARALDI, Pier Giovanni;CASOLARI, Alberto;MANFREDINI, Stefano;
1989

Abstract

A no. of N-​substituted 3-​methyl-​4-​diazo-​5-​pyrazolecarboxamides have been synthesized and tested for their in vitro antibacterial activity. All the compds. have been assayed against several representative gram-​neg. and gram-​pos. bacteria, as well as against some intestinal bacterial species. Some of the 4-​diazopyrazoles have shown a quite interesting broad-​spectrum activity, whereas they are ineffective against the protective intestinal flora. The structure-​activity relationships of the series have been studied quant., via both univariate and multivariate methods: the results are consistent and permit some rationalization of the behavior of the compds. investigated.
1989
Baraldi, Pier Giovanni; Brigidi, P.; Casolari, Alberto; Manfredini, Stefano; Periotto, V.; Recanatini, M.; Roberti, M.; Rossi, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460412
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