The title compd. (I) was prepd. in 84% overall yield from hydroxy ester II by sequential N-protection (dihydropyran, CH2Cl2-4-MeC6H4SO3H, 0°), redn. (NaBH4-MeOH, 0°), chlorination (CCl4-Ph3P reagent), deprotection (aq.-methanolic HCl) and ammonolysis (MeOH-NH3, 90°, 18 h).
A new, efficient synthesis of muscimol (5-ammoniomethylisoxazol-3-olate).
BARCO, Achille;BENETTI, Simonetta;POLLINI, Gian Piero;BARALDI, Pier Giovanni;
1979
Abstract
The title compd. (I) was prepd. in 84% overall yield from hydroxy ester II by sequential N-protection (dihydropyran, CH2Cl2-4-MeC6H4SO3H, 0°), redn. (NaBH4-MeOH, 0°), chlorination (CCl4-Ph3P reagent), deprotection (aq.-methanolic HCl) and ammonolysis (MeOH-NH3, 90°, 18 h).File in questo prodotto:
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