New nitrogen analogues of prostaglandins (11, lla, 12, and 12a) have been synthesized starting from a 4,5-disubstituted 2-pyrrolidinone nucleus (5 and 5a) containing one side chain and a suitable functionality for elaborating the second one. These analogues had no better activity than natural prostaglandins in vitro [guinea pig ileum and trachea, rat stomach fundus strip, uterus and portal vein, ADP-induced guinea pig platelet-rich plasma (PRP) aggregation]. They similarly lacked any interesting activity in vivo [anesthetized rat blood pressure, stress, and acetylsalycilic acid (ASA) induced gastric lesions in rat].

Azaprostaglandin Analogues. Synthesis and Biological Properties of 11-Azaprostaglandin Derivatives

BARCO, Achille;BENETTI, Simonetta;POLLINI, Gian Piero;BARALDI, Pier Giovanni;GUARNERI, Mario;
1981

Abstract

New nitrogen analogues of prostaglandins (11, lla, 12, and 12a) have been synthesized starting from a 4,5-disubstituted 2-pyrrolidinone nucleus (5 and 5a) containing one side chain and a suitable functionality for elaborating the second one. These analogues had no better activity than natural prostaglandins in vitro [guinea pig ileum and trachea, rat stomach fundus strip, uterus and portal vein, ADP-induced guinea pig platelet-rich plasma (PRP) aggregation]. They similarly lacked any interesting activity in vivo [anesthetized rat blood pressure, stress, and acetylsalycilic acid (ASA) induced gastric lesions in rat].
1981
Barco, Achille; Benetti, Simonetta; Pollini, Gian Piero; Baraldi, Pier Giovanni; Guarneri, Mario; Gandolfi, Carmelo; Ceserani, Roberto; Longiave, Dani...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/460386
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