Maintenance of mitochondrial quality is essential for cellular homeostasis. Among processes responsible for preserving healthy mitochondria, mitophagy selectively eliminates dysfunctional mitochondria by targeting them to the autophagosome for degradation. Alterations in mitophagy lead to the accumulation of damaged mitochondria, which plays an essential role in several diseases like carcinogenesis and tumor progression, neurodegenerative disorders, and autoimmune and cardiovascular pathologies.

Calcium homeostasis in the control of mitophagy

Perrone, Mariasole;Patergnani, Simone;Di Mambro, Tommaso;Palumbo, Laura;Giorgi, Carlotta;Pinton, Paolo
2023

Abstract

Maintenance of mitochondrial quality is essential for cellular homeostasis. Among processes responsible for preserving healthy mitochondria, mitophagy selectively eliminates dysfunctional mitochondria by targeting them to the autophagosome for degradation. Alterations in mitophagy lead to the accumulation of damaged mitochondria, which plays an essential role in several diseases like carcinogenesis and tumor progression, neurodegenerative disorders, and autoimmune and cardiovascular pathologies.
2023
Perrone, Mariasole; Patergnani, Simone; Di Mambro, Tommaso; Palumbo, Laura; Więckowski, Mariusz; Giorgi, Carlotta; Pinton, Paolo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2497647
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