Background: Masked diastolic hypotension is a new blood pressure (BP) pattern detected by ambulatory blood pressure monitoring (ABPM) in elderly hypertensives. The aim of this study was to relate ABPM and comorbidity in a cohort of fit elderly subjects attending an outpatient hypertension clinic. Methods: Comorbidity was assessed by Charlson comorbidity index (CCI) and CHA2DS2VASc score. All subjects evaluated with ABPM were aged ≥ 65 years. CCI and CHA2DS2VASc score were calculated. Diastolic hypotension was defined as mean ambulatory diastolic BP < 65 mmHg and logistic regression analysis was carried out in order to detect and independent relationship between comorbidity burden and night-time diastolic BP < 65 mmHg. Results: We studied 174 hypertensive elderly patients aged 72.1 ± 5.2 years, men were 93 (53.4%). Mean CCI was 0.91 ± 1.14 and mean CHA2DS2VASc score of 2.68 ± 1.22. Subjects with night-time mean diastolic values < 65 mmHg were higher in females [54.7% vs. 45.3%, P = 0.048; odds ratio (OR) = 1.914, 95% CI: 1.047.3.500]. Logistic regression analysis showed that only CHA2DS2- VASc score was independently associated with night-time mean diastolic values < 65 mmHg (OR = 1.518, 95% CI: 1.161.1.985; P = 0.002), but CCI was not. Conclusions: ABPM and comorbidity evaluation appear associated in elderly fit subjects with masked hypotension. Comorbid women appear to have higher risk for low ambulatory BP.

Ambulatory diastolic blood pressure: a marker of comorbidity in elderly fit hypertensive individuals?

Alfredo De Giorgi
Primo
;
Rosaria Cappadona
Secondo
Investigation
;
Benedetta Boari;Ruana Tiseo;Giulia Marta Viglione;Christian Molino;Elisa Misurati;Mauro Pasin
Methodology
;
Roberto Manfredini
Penultimo
Writing – Review & Editing
;
Fabio Fabbian
Ultimo
Writing – Original Draft Preparation
2022

Abstract

Background: Masked diastolic hypotension is a new blood pressure (BP) pattern detected by ambulatory blood pressure monitoring (ABPM) in elderly hypertensives. The aim of this study was to relate ABPM and comorbidity in a cohort of fit elderly subjects attending an outpatient hypertension clinic. Methods: Comorbidity was assessed by Charlson comorbidity index (CCI) and CHA2DS2VASc score. All subjects evaluated with ABPM were aged ≥ 65 years. CCI and CHA2DS2VASc score were calculated. Diastolic hypotension was defined as mean ambulatory diastolic BP < 65 mmHg and logistic regression analysis was carried out in order to detect and independent relationship between comorbidity burden and night-time diastolic BP < 65 mmHg. Results: We studied 174 hypertensive elderly patients aged 72.1 ± 5.2 years, men were 93 (53.4%). Mean CCI was 0.91 ± 1.14 and mean CHA2DS2VASc score of 2.68 ± 1.22. Subjects with night-time mean diastolic values < 65 mmHg were higher in females [54.7% vs. 45.3%, P = 0.048; odds ratio (OR) = 1.914, 95% CI: 1.047.3.500]. Logistic regression analysis showed that only CHA2DS2- VASc score was independently associated with night-time mean diastolic values < 65 mmHg (OR = 1.518, 95% CI: 1.161.1.985; P = 0.002), but CCI was not. Conclusions: ABPM and comorbidity evaluation appear associated in elderly fit subjects with masked hypotension. Comorbid women appear to have higher risk for low ambulatory BP.
2022
DE GIORGI, Alfredo; Cappadona, Rosaria; Savriè, Caterina; Boari, Benedetta; Tiseo, Ruana; Viglione, Giulia Marta; Molino, Christian; Misurati, Elisa; Pasin, Mauro; Manfredini, Roberto; Fabbian, Fabio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2490345
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