Epigenetics encompasses a group of dynamic, reversible, and heritable modifications that occur within cells that are independent of gene mutations. These alterations are highly influenced by the environment, from the environment that surrounds the human being to the internal microen-vironments located within tissues and cells. The ways that pigenetic modifications promote the initiation of the tumorigenic process have been widely demonstrated. Similarly, it is well known that carcinogenesis is supported and prompted by a strong proinflammatory environment. In this review, we introduce our report of a proinflammatory microenvironment that encircles the tumor core but can be responsible for the induction of epigenetic drift. At the same time, cancer cells can alter their epigenetic profile to generate a positive loop in the promotion of the inflammatory process. Therefore, an in-depth understanding of the epigenetic networks between the tumor microenvironment and cancer cells might highlight new targetable mechanisms that could prevent tumor progression.

Epigenetic Regulation: A Link between Inflammation and Carcinogenesis

Vezzani B.
Primo
;
Carinci M.
Secondo
;
Previati M.;Giacovazzi S.;Della Sala M.;Gafa R.;Lanza G.;Wieckowski M. R.;Pinton P.
Penultimo
;
Giorgi C.
Ultimo
2022

Abstract

Epigenetics encompasses a group of dynamic, reversible, and heritable modifications that occur within cells that are independent of gene mutations. These alterations are highly influenced by the environment, from the environment that surrounds the human being to the internal microen-vironments located within tissues and cells. The ways that pigenetic modifications promote the initiation of the tumorigenic process have been widely demonstrated. Similarly, it is well known that carcinogenesis is supported and prompted by a strong proinflammatory environment. In this review, we introduce our report of a proinflammatory microenvironment that encircles the tumor core but can be responsible for the induction of epigenetic drift. At the same time, cancer cells can alter their epigenetic profile to generate a positive loop in the promotion of the inflammatory process. Therefore, an in-depth understanding of the epigenetic networks between the tumor microenvironment and cancer cells might highlight new targetable mechanisms that could prevent tumor progression.
2022
Vezzani, B.; Carinci, M.; Previati, M.; Giacovazzi, S.; Della Sala, M.; Gafa, R.; Lanza, G.; Wieckowski, M. R.; Pinton, P.; Giorgi, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2480272
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