Immune activation and inflammation due to HIV infection is currently considered the driving force of CD4+ T-cell depletion and of the functional impairment of the immune system [1]. o Hepatitis C virus (HCV) coinfection, has been suggested as contributing to immune activation. Since direct-acting antiviral agents (DAAs) has been introduced, HCV has been treated and eradicated in a large proportion of HIV/HCV- coinfected patients. However, the impact that HCV eradication has on immune activation and immune recovery is still unclear [1-3]. o We want to investigate CD4+, CD8+ T-cell count, and CD4/CD8 ratio trend in cirrhotic and not-cirrhotic HIV/HCV-coinfected patients after DAAs treatment and HCV eradication.

CD4+ T- cell count and CD4/CD8 ratio trend after HCV eradication in HCV/HIV-coinfected subjects treated with DAAs: an observational retrospective study over a 4 year period.

Di Nuzzo Mariachiara;Segala Daniela;Sighinolfi Laura.
2019

Abstract

Immune activation and inflammation due to HIV infection is currently considered the driving force of CD4+ T-cell depletion and of the functional impairment of the immune system [1]. o Hepatitis C virus (HCV) coinfection, has been suggested as contributing to immune activation. Since direct-acting antiviral agents (DAAs) has been introduced, HCV has been treated and eradicated in a large proportion of HIV/HCV- coinfected patients. However, the impact that HCV eradication has on immune activation and immune recovery is still unclear [1-3]. o We want to investigate CD4+, CD8+ T-cell count, and CD4/CD8 ratio trend in cirrhotic and not-cirrhotic HIV/HCV-coinfected patients after DAAs treatment and HCV eradication.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2417786
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