Background: Melusin is a small-chaperone protein selectively expressed in the heart and skeletal muscles. In the heart, melusin plays a protective role in different pathologic conditions. Indeed, previous experiments in several pre-clinical models indicated that melusin overexpression prevents cardiac dilation and fibrotic tissue deposition, cardiomyocytes apoptosis and sustains a compensatory hypertrophic response with retained contractile function.
Melusin modulates fatty acids β-oxidation and ROS production in the heart
G Morciano;P Pinton;
2018
Abstract
Background: Melusin is a small-chaperone protein selectively expressed in the heart and skeletal muscles. In the heart, melusin plays a protective role in different pathologic conditions. Indeed, previous experiments in several pre-clinical models indicated that melusin overexpression prevents cardiac dilation and fibrotic tissue deposition, cardiomyocytes apoptosis and sustains a compensatory hypertrophic response with retained contractile function.File in questo prodotto:
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