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EnglishThe Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a missense mutation inPOPDC1. Evidence suggests that POPDC proteins control membrane trafficking of interacting proteins. Furthermore, we will discuss the current catalogue of established protein-protein interactions. In recent years, the number of POPDC-interacting proteins is rising and currently includes ion channels (TREK-1), sarcolemma-associated proteins serving functions in mechanical stability (Dystrophin), compartmentalization (Caveolin 3), scaffolding (ZO-1), trafficking (NDRG4, VAMP2/3) and repair (Dysferlin), or acting as a guanine nucleotide exchange factor for Rho-family GTPases (GEFT). Recent evidence suggests that POPDC proteins might also control the cellular level of the nuclear proto-oncoprotein c-Myc. These data suggests that this family of cAMP-binding proteins probably serves multiple roles in striated muscle.
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| Data di pubblicazione: | 2016 | |
| Titolo: | The Popeye Domain Containing Genes and their Function in Striated Muscle | |
| Autori: | Schindler, Roland Fr; Scotton, Chiara; French, Vanessa; Ferlini, Alessandra; Brand, Thomas | |
| Rivista: | JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE | |
| Keywords: | atrioventricular block; cardiac arrhythmia; cyclic AMP; limb-girdle muscular dystrophy; membrane protein; membrane trafficking; sinus bradycardia | |
| Abstract in inglese: | The Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here we will review their role in striated muscle as deduced from work in cell and animal models and the recent analysis of patients carrying a missense mutation inPOPDC1. Evidence suggests that POPDC proteins control membrane trafficking of interacting proteins. Furthermore, we will discuss the current catalogue of established protein-protein interactions. In recent years, the number of POPDC-interacting proteins is rising and currently includes ion channels (TREK-1), sarcolemma-associated proteins serving functions in mechanical stability (Dystrophin), compartmentalization (Caveolin 3), scaffolding (ZO-1), trafficking (NDRG4, VAMP2/3) and repair (Dysferlin), or acting as a guanine nucleotide exchange factor for Rho-family GTPases (GEFT). Recent evidence suggests that POPDC proteins might also control the cellular level of the nuclear proto-oncoprotein c-Myc. These data suggests that this family of cAMP-binding proteins probably serves multiple roles in striated muscle. | |
| Digital Object Identifier (DOI): | 10.3390/jcdd3020022 | |
| Handle: | http://hdl.handle.net/11392/2384586 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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