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EnglishMitochondria-associated membranes are juxtaposed between the endoplasmic reticulum and mitochondria and have been identified as a critical hub in the regulation of apoptosis and tumor growth. One key function of mitochondria-associated membranes is to provide asylum to a number of proteins with tumor suppressor and oncogenic properties. In this review, we discuss how Ca2+ flux manipulation represents the primary mechanism underlying the action of several oncogenes and tumor-suppressor genes and how these networks might be manipulated to provide novel therapies for cancer. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech.
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| Data di pubblicazione: | 2017 | |
| Titolo: | Endoplasmic reticulum-mitochondria Ca2+ crosstalk in the control of the tumor cell fate | |
| Autori: | Missiroli, Sonia; Danese, Alberto; Iannitti, Tommaso; Patergnani, Simone; Perrone, Mariasole; Previati, Maurizio; Giorgi, Carlotta; Pinton, Paolo | |
| Rivista: | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | |
| Parole Chiave: | Molecular Biology; Cell Biology | |
| Abstract in inglese: | Mitochondria-associated membranes are juxtaposed between the endoplasmic reticulum and mitochondria and have been identified as a critical hub in the regulation of apoptosis and tumor growth. One key function of mitochondria-associated membranes is to provide asylum to a number of proteins with tumor suppressor and oncogenic properties. In this review, we discuss how Ca2+ flux manipulation represents the primary mechanism underlying the action of several oncogenes and tumor-suppressor genes and how these networks might be manipulated to provide novel therapies for cancer. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech. | |
| Digital Object Identifier (DOI): | 10.1016/j.bbamcr.2016.12.024 | |
| Handle: | http://hdl.handle.net/11392/2371001 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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