Poorly soluble and/or permeable molecules jeopardize the discovery and development of innovative medicines. Pharmaceutical co-crystals, formed by an active pharmaceutical substance (API) and a co-crystal former, can show enhanced dissolution and permeation values compared with those of the parent crystalline pure phases. It is currently assumed that co-crystallization with pharmaceutical excipients does not affect the pharmacological activity of an API or, indeed, might even improve physical properties such as solubility and permeability. However, as we highlight here, the biological behavior of co-crystals can differ drastically with respect to that of their parent physical mixtures.

Can pharmaceutical co-crystals provide an opportunity to modify the biological properties of drugs?

DALPIAZ, Alessandro
Primo
Membro del Collaboration Group
;
PAVAN, Barbara
Secondo
Membro del Collaboration Group
;
FERRETTI, Valeria
Ultimo
Membro del Collaboration Group
2017

Abstract

Poorly soluble and/or permeable molecules jeopardize the discovery and development of innovative medicines. Pharmaceutical co-crystals, formed by an active pharmaceutical substance (API) and a co-crystal former, can show enhanced dissolution and permeation values compared with those of the parent crystalline pure phases. It is currently assumed that co-crystallization with pharmaceutical excipients does not affect the pharmacological activity of an API or, indeed, might even improve physical properties such as solubility and permeability. However, as we highlight here, the biological behavior of co-crystals can differ drastically with respect to that of their parent physical mixtures.
Dalpiaz, Alessandro; Pavan, Barbara; Ferretti, Valeria
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2368521
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