Objectives: We evaluated the association between fat mass and its distribution with chronic low-grade inflammation and carotid IMT. Subjects and Methods: 203 healthy subjects (age 59 4- 11 years; 144 postmenopausal women and 59 men) were enrolled. Clinical parameters, fasting plasma glucose (FPG) and insulin (FPI), serum lipids, IL6, ILl0, TNF alpha, hCRP were evaluated. Insulin sensitivity was calculated by HOMA model. Carotid IMT was evaluated by high-resolution ultrasonography. Total body fat (FM) was assessed by Bioelectrical Impedance Analysis (BIA). Subjects were categorized according to IMT (IMT < 1 mm and IMT _> 1 ram). Results: In univaxiate analysis both FM % and IMT were positively correlated with FPI, HOMA index, hCRR IL6 and TNF alpha and negatively correlated with ILl0. IMT was also positively correlated with adiposity indexes (waist circumference and FM% but not BMI). The group with IMT _> 1 mm and the group with IMT < 1 mm did not differ for age, systolic and diastolic blood pressure, FPG, FPI, lipid profile, and BMI; however, waist circumference, FM%, hCRR IL6, ILl0 and TNFalpha were significantly different. A stepwise multiple regression analysis explained 93% of the variance in IMT trough waist circumference, FM %, HOMA index and IL-10. Condusion: Healthy subjects with higher FM% had higher insulin resistance and a state of chronic low-grade inflammation. IMT was correlated with all adiposity measures (but not to BMI), insulin sensitivity and cytokines.
Adiposity is an important determinant of chronic low-grade inflammation and is associated with carotid artery intima-media thickness
PASSARO, Angelina;DALLA NORA, Edoardo;MARI, Elisa;MARCELLO, Maria Caterina;FELLIN, Renato
2006
Abstract
Objectives: We evaluated the association between fat mass and its distribution with chronic low-grade inflammation and carotid IMT. Subjects and Methods: 203 healthy subjects (age 59 4- 11 years; 144 postmenopausal women and 59 men) were enrolled. Clinical parameters, fasting plasma glucose (FPG) and insulin (FPI), serum lipids, IL6, ILl0, TNF alpha, hCRP were evaluated. Insulin sensitivity was calculated by HOMA model. Carotid IMT was evaluated by high-resolution ultrasonography. Total body fat (FM) was assessed by Bioelectrical Impedance Analysis (BIA). Subjects were categorized according to IMT (IMT < 1 mm and IMT _> 1 ram). Results: In univaxiate analysis both FM % and IMT were positively correlated with FPI, HOMA index, hCRR IL6 and TNF alpha and negatively correlated with ILl0. IMT was also positively correlated with adiposity indexes (waist circumference and FM% but not BMI). The group with IMT _> 1 mm and the group with IMT < 1 mm did not differ for age, systolic and diastolic blood pressure, FPG, FPI, lipid profile, and BMI; however, waist circumference, FM%, hCRR IL6, ILl0 and TNFalpha were significantly different. A stepwise multiple regression analysis explained 93% of the variance in IMT trough waist circumference, FM %, HOMA index and IL-10. Condusion: Healthy subjects with higher FM% had higher insulin resistance and a state of chronic low-grade inflammation. IMT was correlated with all adiposity measures (but not to BMI), insulin sensitivity and cytokines.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
