Background: DSM-V considers self-complaint of cognitive decline an important item for the diagnosis of neurocognitive disorders. MASQ (Multiple Ability Self- Report Questionnaire) has been used for self-assessment of cognitive function in different sets of patients but it has never been used in general population. Aim of our study was to compare self-appraisal of cognitive function with an objective evaluation in a cohort of subjects over sixty years of age. Methods: the cognitive function of 152 subjects (mean age 67, range 60-81) enrolled in the PANGeA Study was evaluated with MoCA (Montreal Cognitive Assessment) test. All subjects fulfilled the MASQ and a questionnaire evaluating social, demographic and psychological items. Results: MASQ score positively correlated with MoCA score (r=0,187, p=0,001). Both MoCA and MASQ scores correlated with self-assessed health status (r=0.289, p<0.001 and r=0.367, p<0.001, respectively), global quality of life (r=0.219, p=0.008 and r=0.299, p<0.001 respectively), years of education (r=0.503 p<0.001 and 0.228 p=0.005, respectively) but MASQ correlated also with self-assessed physical performance (r=0.299, p<0.001), psychological health (r=0.290, p<0.001), comorbidity (r=-0.287, p<0.001), and sleeping hours(r=0.197, p=0.015). The linear regression analysis showed that MOCA score predicts MASQ score independently of self-assessed global health status and psychological wellness (Adjusted R2=0,187, p<0,001). Conclusions: MASQ seems to be a good indicator of cognitive functions in general population over sixty despite a possible influence of psycho-affective variables. We aim to further study the role of MASQ in the screening of cognitive disorders in the elderly.