Nasal administration allows for direct transport of active substances from the olfactory epithelium to the brain. In nose-to-brain drug delivery in vitro methods can be set up to study permeation characteristics and guide formulation development. Here, the permeation of antiviral ribavirin, inverse agonist for the cannabinoid receptor CB1 rimonabant and recombinant human insulin were studied.
In vitro transport studies across excised nasal mucosa for three drug candidates to nose-to-brain delivery
COLOMBO, Gaia;BORTOLOTTI, Fabrizio;
2014
Abstract
Nasal administration allows for direct transport of active substances from the olfactory epithelium to the brain. In nose-to-brain drug delivery in vitro methods can be set up to study permeation characteristics and guide formulation development. Here, the permeation of antiviral ribavirin, inverse agonist for the cannabinoid receptor CB1 rimonabant and recombinant human insulin were studied.File in questo prodotto:
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