The emergence of antibiotic-resistant bacterial strains is a challenging problem that has led to an urgent global call for new antimicrobial drugs. Such compounds, potentially devoid of undesirable side-effects, have been sought in particular from natural resources. We have been studying the pharmacological potential of leaf components of M. communis and A. arborescens, deserving special interest to their antimicrobial activity for possible future applications in fish aquaculture. Ethanolic extracts from the two plant species were essayed in vitro for their effects on Listonella (Vibrio) anguillarum and Photobacterium damselae ssp. piscicida strains. These Gram- bacteria are two major pathogens for the cultured gilthead seabream (Sparus aurata), being the causative agents of vibriosis and pasteurellosis, respectively. Furthermore, the immunomodulatory effects of the plant-derived extracts on a LPS-stimulated S. aurata fibroblast cell line (SAF-1) were evaluated. Obtained results have provided a promising new perspective for the use of medicinal plants to prevent or oppose bacterial diseases in fish.
Antibacterial activity and immunomodulatory effects on a sea bream cell line of Myrtus communis and Aloe arborescens extracts
ABELLI, Luigi;
2011
Abstract
The emergence of antibiotic-resistant bacterial strains is a challenging problem that has led to an urgent global call for new antimicrobial drugs. Such compounds, potentially devoid of undesirable side-effects, have been sought in particular from natural resources. We have been studying the pharmacological potential of leaf components of M. communis and A. arborescens, deserving special interest to their antimicrobial activity for possible future applications in fish aquaculture. Ethanolic extracts from the two plant species were essayed in vitro for their effects on Listonella (Vibrio) anguillarum and Photobacterium damselae ssp. piscicida strains. These Gram- bacteria are two major pathogens for the cultured gilthead seabream (Sparus aurata), being the causative agents of vibriosis and pasteurellosis, respectively. Furthermore, the immunomodulatory effects of the plant-derived extracts on a LPS-stimulated S. aurata fibroblast cell line (SAF-1) were evaluated. Obtained results have provided a promising new perspective for the use of medicinal plants to prevent or oppose bacterial diseases in fish.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
