99mTc-HMPAO is currently used to image cerebral blood flow and for in vitro leukocyte labeling. The jield of this liphophilic complex plays an important role in diffusion across the blood brain barrier and in cell labeling. Instability in the vial occurs relatively fast at RT and can limit the use of 99mTc-HMPAO to only a short interval following its preparation. We studied the influence, on the radiochemical purity and stability of this 99mTc complex of different characteristics of the 0,9% NaCl used to dilute generator-produced sodium pertechnetate.

Preparation of 99mTc-HMPAO: influence of pH, volume recovery and storage conditions of the physiological solution on radiochemical purity and stability.

UCCELLI, Licia;BOSCHI, Alessandra;
2013

Abstract

99mTc-HMPAO is currently used to image cerebral blood flow and for in vitro leukocyte labeling. The jield of this liphophilic complex plays an important role in diffusion across the blood brain barrier and in cell labeling. Instability in the vial occurs relatively fast at RT and can limit the use of 99mTc-HMPAO to only a short interval following its preparation. We studied the influence, on the radiochemical purity and stability of this 99mTc complex of different characteristics of the 0,9% NaCl used to dilute generator-produced sodium pertechnetate.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/2076212
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