The present study focused on the preparation, characterization and in vivo biological evaluation of a new class of high bone affinity 99mTc-labeled bisphosphonates-bile acid derivatives. In particular four different bile acid (chenodeoxy-cholic, ursodeoxycholic, hydeoxycholic annd cholic acid) conjugated with bisphosphonate were labeled with 99mTc and SPECT studies werw carried out in normal mice. The present findings indicate that 99mTc-ursodeoxychoilc-bisphosphonate holds great potential for bone scintigraphy and may also be examined for its ability to bind 188Re with a view to developing a potential therapeutic agent.
Development of new 99mTc-labeled bisphosphonates for bone scintigraphy
PASQUALI, Micol;UCCELLI, Licia;BOSCHI, Alessandra;DI DOMENICO, Giovanni;PUPILLO, Gaia;GIGANTI, Melchiore;BORTOLINI, Olga;BERNARDI, Tatiana;DUATTI, Adriano
2013
Abstract
The present study focused on the preparation, characterization and in vivo biological evaluation of a new class of high bone affinity 99mTc-labeled bisphosphonates-bile acid derivatives. In particular four different bile acid (chenodeoxy-cholic, ursodeoxycholic, hydeoxycholic annd cholic acid) conjugated with bisphosphonate were labeled with 99mTc and SPECT studies werw carried out in normal mice. The present findings indicate that 99mTc-ursodeoxychoilc-bisphosphonate holds great potential for bone scintigraphy and may also be examined for its ability to bind 188Re with a view to developing a potential therapeutic agent.File in questo prodotto:
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