MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known as to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b overexpression is triggered in mice and humans by APC loss, PTEN/PI3K pathway deregulation, and SRC overexpression and promotes tumor transformation and progression. We show that miR-135b upregulation is common in sporadic and inflammatory bowel disease-associated human CRCs and correlates with tumor stage and poor clinical outcome. Inhibition of miR-135b in CRC mouse models reduces tumor growth by controlling genes involved in proliferation, invasion, and apoptosis. We identify miR-135b as a key downsteam effector of oncogenic pathways and a potential target for CRC treatment.

microRNA-135b promotes cancer progression acting as a downstream effector of oncogenic pathways in colon cancer

LANZA, Giovanni;GAFA', Roberta;Carlo M. Croce
2014

Abstract

MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known as to whether it represents a bystander event or actually drives tumor progression in vivo. We show that miR-135b overexpression is triggered in mice and humans by APC loss, PTEN/PI3K pathway deregulation, and SRC overexpression and promotes tumor transformation and progression. We show that miR-135b upregulation is common in sporadic and inflammatory bowel disease-associated human CRCs and correlates with tumor stage and poor clinical outcome. Inhibition of miR-135b in CRC mouse models reduces tumor growth by controlling genes involved in proliferation, invasion, and apoptosis. We identify miR-135b as a key downsteam effector of oncogenic pathways and a potential target for CRC treatment.
2014
Nicola, Valeri1; Chiara, Braconi; Pierluigi, Gasparini; Claudio, Murgia; Andrea, Lampis; Viola Paulus Hock, ; Hart, Jonathan R.; Lynn, Ueno; Grivennikov, Sergei I.; Francesca, Lovat; Alessio, Paone; Luciano, Cascione; Sumani, Khlea M.; Angelo, Veronese; Muller, Fabbri; Stefania, Carasi; Hansjuerg, Alder; Lanza, Giovanni; Gafa', Roberta; Moyer, Mary P.; Ridgway, Rachel A.; Julia, Cordero; Nuovo, Gerard J.; Wendy, Frankel; Massimo, Rugge; Matteo, Fassan; Joanna, Groden; Vogt, Peter K.; Michael, Karin; Sansom, Owen J.; Croce, Carlo M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1960012
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