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EnglishAllosteric modulators of adenosine receptors represent an alternative to direct-acting adenosine agonists and nucleoside uptake blockers, preferably those can selectively modulate the response to adenosine in only those organs or localized areas of a given organ in which production of adenosine is increased. Allosteric enhancers at the adenosine A1 receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, this class of compounds has therapeutic potential as analgesics and neuroprotective agents.
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| Data di pubblicazione: | 2013 | |
| Titolo: | Allosteric modulation of A1-adenosine receptor: A review | |
| Autori: | M., Kimatrai Salvador; Baraldi, Pier Giovanni; Romagnoli, Romeo | |
| Rivista: | DRUG DISCOVERY TODAY: TECHNOLOGIES | |
| Abstract: | Allosteric modulators of adenosine receptors represent an alternative to direct-acting adenosine agonists and nucleoside uptake blockers, preferably those can selectively modulate the response to adenosine in only those organs or localized areas of a given organ in which production of adenosine is increased. Allosteric enhancers at the adenosine A1 receptor have received attention as anti-arrhythmic cardiac agents, and, more recently, as anti-lipolytic agents. In addition, this class of compounds has therapeutic potential as analgesics and neuroprotective agents. | |
| Digital Object Identifier (DOI): | 10.1016/j.ddtec.2012.08.005 | |
| Handle: | http://hdl.handle.net/11392/1799699 | |
| Appare nelle tipologie: | 03.1 Articolo su rivista |
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