Design, synthesis and characterization of peptides which inhibit the first coagulation steps by competing with FVII for the interaction with tissue factor or with factor IX and factor X. This inhibition is aimed at preventing the thrombotic episodes in thromboembolic disease. The selective inhibition of the FVIIa-TF mediated activation of FIX or FX coul also be exploited for diagnostic purposes in the clinical coagulation laboratory.
CNR Progetto Finalizzato Biotecnologie-Area Ing Molecolare e Biologia Strutturale: "Peptides and antibodies which inhibit or recognize the factor VII-TF complex in thromboembolic disease.
BERNARDI, Francesco
1997
Abstract
Design, synthesis and characterization of peptides which inhibit the first coagulation steps by competing with FVII for the interaction with tissue factor or with factor IX and factor X. This inhibition is aimed at preventing the thrombotic episodes in thromboembolic disease. The selective inhibition of the FVIIa-TF mediated activation of FIX or FX coul also be exploited for diagnostic purposes in the clinical coagulation laboratory.File in questo prodotto:
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