Reductive ring cleavage reactions of 3, 5-disubstituted isoxazoles to α,β-unsaturated 1, 4-ketones are reported. The 2, 5-undecanedione (5) was prepared by two different procedures starting from the masked isoxazoles 2 and G. Conversion of 2 and 6 toα, β-unsaturated ketones 3 and 10, followed by selective reduction with an iron-based complex under mild reaction conditions and removal of the protecting ketal group, gave 5. © 1979, American Chemical Society. All rights reserved.

1,4-Diketones via Isoxazole Intermediates

BARCO, Achille
Primo
;
BENETTI, Simonetta
Secondo
;
POLLINI, Gian Piero
;
BARALDI, Pier Giovanni;VICENTINI, Chiara Beatrice
Ultimo
1979

Abstract

Reductive ring cleavage reactions of 3, 5-disubstituted isoxazoles to α,β-unsaturated 1, 4-ketones are reported. The 2, 5-undecanedione (5) was prepared by two different procedures starting from the masked isoxazoles 2 and G. Conversion of 2 and 6 toα, β-unsaturated ketones 3 and 10, followed by selective reduction with an iron-based complex under mild reaction conditions and removal of the protecting ketal group, gave 5. © 1979, American Chemical Society. All rights reserved.
Barco, Achille; Benetti, Simonetta; Pollini, Gian Piero; Baraldi, Pier Giovanni; Guarneri, Mario; Vicentini, Chiara Beatrice
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1616082
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