The activity and stability under flow conditions of covalently and non-covalently silica supported proline and proline-like organocatalysts is herein described. The slow aldol reaction of cyclohexanone with p-nitro benzaldehyde and the fast α-amination of isovaleraldehyde with dibenzyl azodicarboxylate have been selected as model reactions for this study. Prospects and limitations of the disclosed continuous-flow organocatalytic approach are widely discussed. © 2010 Elsevier Ltd. All rights reserved.

Toward the optimization of continuous-flow aldol and alpha-amination reactions by means of proline-functionalized silicon packed-bed microreactors

MASSI, Alessandro;CAVAZZINI, Alberto;DEL ZOPPO, Luisa;PANDOLI, Omar;COSTA, Valentina;PASTI, Luisa;GIOVANNINI, Pier Paolo
2011

Abstract

The activity and stability under flow conditions of covalently and non-covalently silica supported proline and proline-like organocatalysts is herein described. The slow aldol reaction of cyclohexanone with p-nitro benzaldehyde and the fast α-amination of isovaleraldehyde with dibenzyl azodicarboxylate have been selected as model reactions for this study. Prospects and limitations of the disclosed continuous-flow organocatalytic approach are widely discussed. © 2010 Elsevier Ltd. All rights reserved.
Massi, Alessandro; Cavazzini, Alberto; DEL ZOPPO, Luisa; Pandoli, Omar; Costa, Valentina; Pasti, Luisa; Giovannini, Pier Paolo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11392/1505317
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