show peculiar clinicopathological features and a favorable clinical outcome. We tested whether the improved prognosis of these patients is related to the content of activated cytotoxic intraepithelial lymphocytes (lELs). Methods: MSI status and the amount of activated cytotoxic lELs were investigated in the 109 right-sided, stage ll/lll colon carcinomas from a series of 1,265 consecutive patients that underwent radical surgery between January 1987 and December 1993. Association with clinicopathological features, survival and disease recurrence were tested against MSI status and the number of cytotoxic lELs. Results: MSI-H was found in 43% of stage ll/lll proximal colon cancers and was associated with a significantly higher proportion of activated cytotoxic lELs (Granzyme B+). Multivariate analysis showed that MSI-H, as well as the content of CD3+, CD8+ and Granzyme B+ lELs were independently related to improved overall and disease-free survival. Furthermore, MSI-H and high numbers of activated cytotoxic lELs exerted a quasi-multiplicative positive effect on the prognosis of these patients. Conclusions: The presence of local cytotoxic immune responses is strongly correlated with the better prognosis of MSI-H colon cancer patients. Furthermore, the combined analysis of MSI status and cytotoxic lELs identified a subset of colon cancer patients with a very favorable clinical outcome, particularly within stage III disease.
Prognostic value of microsatellite instability and intratumor activated cytotoxic lymphocytes in colon cancer
GUIDOBONI M;GAFA', Roberta;LANZA, Giovanni;
2000
Abstract
show peculiar clinicopathological features and a favorable clinical outcome. We tested whether the improved prognosis of these patients is related to the content of activated cytotoxic intraepithelial lymphocytes (lELs). Methods: MSI status and the amount of activated cytotoxic lELs were investigated in the 109 right-sided, stage ll/lll colon carcinomas from a series of 1,265 consecutive patients that underwent radical surgery between January 1987 and December 1993. Association with clinicopathological features, survival and disease recurrence were tested against MSI status and the number of cytotoxic lELs. Results: MSI-H was found in 43% of stage ll/lll proximal colon cancers and was associated with a significantly higher proportion of activated cytotoxic lELs (Granzyme B+). Multivariate analysis showed that MSI-H, as well as the content of CD3+, CD8+ and Granzyme B+ lELs were independently related to improved overall and disease-free survival. Furthermore, MSI-H and high numbers of activated cytotoxic lELs exerted a quasi-multiplicative positive effect on the prognosis of these patients. Conclusions: The presence of local cytotoxic immune responses is strongly correlated with the better prognosis of MSI-H colon cancer patients. Furthermore, the combined analysis of MSI status and cytotoxic lELs identified a subset of colon cancer patients with a very favorable clinical outcome, particularly within stage III disease.I documenti in SFERA sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
