The conformation of several Phe-D-Leu-Phe-D-Leu-Phe analogues was analyzed using infrared absorption and circular dichroism. Their effect on human neutrophils was verified by receptor binding and chemotaxis assays. The results demonstrate that the compounds examined prefer an ordered conformation (beta-turn) in amphipatic environment, and that they are able to antagonize the neutrophil functions evoked by CHO-Met-Leu-Phe.

Conformational aspects of human formylpeptide receptor antagonists

SCATTURIN, Angelo;VERTUANI, Gianni;DALPIAZ, Alessandro;FERRETTI, Maria Enrica;SPISANI, Susanna
1999

Abstract

The conformation of several Phe-D-Leu-Phe-D-Leu-Phe analogues was analyzed using infrared absorption and circular dichroism. Their effect on human neutrophils was verified by receptor binding and chemotaxis assays. The results demonstrate that the compounds examined prefer an ordered conformation (beta-turn) in amphipatic environment, and that they are able to antagonize the neutrophil functions evoked by CHO-Met-Leu-Phe.
1999
Scatturin, Angelo; Vertuani, Gianni; Pecoraro, R.; Dalpiaz, Alessandro; Boggian, M.; Ferretti, Maria Enrica; Spisani, Susanna
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11392/1201127
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